Abstract: A fishing spinning reel comprises a line roller that guides a fishing line to a spool around which the fishing line is wound and held. The line roller comprises a roller that is rotatably provided in a shaft portion with bearings interposed therebetween. The roller comprises: a fishing line guiding portion that is disposed on a side of a bail support member, and guides the fishing line to the spool; a fishing line leading portion that is formed to have a diameter that is greater than the diameter of the fishing line guiding portion, and leads the fishing line to the fishing line guiding portion; and a fishing line regulating portion that is disposed between the fishing line guiding portion and the fishing line leading portion to be inclined, and regulates a movement of the fishing line in an axial direction of the shaft portion.

Abstract: A method is provided for purifying physiologically active proteins, especially antibodies, in order to remove impurities such as DNA contaminants and viruses with minimal loss of physiologically active proteins. The physiologically active protein is introduced into an aqueous solution of low conductivity at a pH of below the isoelectric point of the physiologically active protein to precipitate impurities as particles. The particles are removed, leaving a purified physiologically active protein.

Abstract: A method is provided for purifying physiologically active proteins, especially antibodies, in order to remove impurities such as DNA contaminants and viruses with minimal loss of physiologically active proteins. The physiologically active protein is introduced into an aqueous solution of low conductivity at a pH of below the isoelectric point of the physiologically active protein to precipitate impurities as particles. The particles are removed, leaving a purified physiologically active protein.

Abstract: A method for manufacturing an antibody formulation in which DNA contaminants are removed by binding the antibody to a protein-A or probtin-G affinity column and eluting the antibody with an acidic eluting solution, preferably of low conductivity.

Abstract: According to an embodiment, a fishing spinning reel includes an assembly structure of a handle with which to prevent backlash at a handle part and facilitate an assembly operation and a folding operation of the handle part. The fishing spinning reel according to the embodiment includes a driving shaft integrated with a drive gear, a handle arm rotating in response to an operation of a handle, a handle shaft axially supporting the handle arm in a pivotable manner on one end, rotating in response to the rotation of the handle arm, and divided from the driving shaft in an axial direction, and a tubular member connected to each of the driving shaft and the handle shaft in an integrally rotatable manner, and including a first engagement portion engaged with the driving shaft and a second engagement portion engaged with the handle arm in a state where the handle is used.

Abstract: A method for manufacturing an antibody formulation in which DNA contaminants are removed by binding the antibody to a protein-A or probtin-G affinity column and eluting the antibody with an acidic eluting solution, preferably of low conductivity.

Abstract: A method for manufacturing an antibody formulation in which DNA contaminants are removed by binding the antibody to a protein-A or probtin-G affinity column and eluting the antibody with an acidic eluting solution, preferably of low conductivity.

Abstract: A method is provided for purifying physiologically active proteins, especially antibodies, in order to remove impurities such as DNA contaminants and viruses with minimal loss of physiologically active proteins. The physiologically active protein is introduced into an aqueous solution of low conductivity at a pH of below the isoelectric point of the physiologically active protein to precipitate impurities as particles. The particles are removed, leaving a purified physiologically active protein.

Abstract: Problems to be Solved: The present invention provides a simpler and less expensive method for purifying physiologically active proteins, especially antibodies, which can ensure removal of impurities such as DNA contaminants and viruses, and which can minimize a loss of physiologically active proteins. Means for Solving the Problems: A method for removing impurities in a physiologically active protein-containing sample, which comprises the following steps: 1) allowing the physiologically active protein-containing sample to be converted into an aqueous solution of low conductivity at a pH below the isoelectric point of the physiologically active protein; and 2) removing the resulting particles.

Abstract: A fishing gear in which an attached part (8) is assembled onto a main body member (6) formed of a base metal protected by an insulating coating, characterized in that a fixing member (20) for attaching and fixing the attached part to the main body member (6) is formed of an aluminum alloy in which an Fe component is 0.6 wt. % or less, a Cu component is 0.2 wt. % or less, an Ni component is 0.1 wt. % or less, and a Ti component is 0.03 wt. % or less.

Abstract: A fishing gear in which an attached part (8) is assembled onto a main body member (6) formed of a base metal protected by an insulating coating, characterized in that a fixing member (20) for attaching and fixing the attached part to the main body member (6) is formed of an aluminum alloy in which an Fe component is 0.6 wt. % or less, a Cu component is 0.2 wt. % or less, an Ni component is 0.1 wt. % or less, and a Ti component is 0.03 wt. % or less.

Abstract: A spinning reel for fishing includes: a reel body including a front portion; a handle provided in the reel body; a cap-shaped cover body including a surrounding wall mounted in the front portion of the reel body; a spool on which a fishing line is to be wound; a rotor including a fishing line guide part, the rotor being rotated by the rotational manipulation of the handle to wind the fishing line on the spool; a driving part passing through the cover body and transmitting the rotation of the handle to the rotor; a support part provided in the front portion of the reel body and supporting the driving part; and a magnetic seal device mounted in the cover body and including a magnet, a cylindrical magnetic body forming a magnetic circuit between the magnetic body and the magnet and magnetic fluid maintained between the magnet and the magnetic ring.

Abstract: A spinning reel for fishing includes: a reel body including a front portion; a handle provided in the reel body; a cap-shaped cover body including a surrounding wall mounted in the front portion of the reel body; a spool on which a fishing line is to be wound; a rotor including a fishing line guide part, the rotor being rotated by the rotational manipulation of the handle to wind the fishing line on the spool; a driving part passing through the cover body and transmitting the rotation of the handle to the rotor; a support part provided in the front portion of the reel body and supporting the driving part; and a magnetic seal device mounted in the cover body and including a magnet, a cylindrical magnetic body forming a magnetic circuit between the magnetic body and the magnet and magnetic fluid maintained between the magnet and the magnetic ring.