Abstract: The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.

Abstract: The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having an increased copy number of the CRM197 gene, wherein the method comprises growing the strain in media free of animal-derived components with one or more amino acids.

Abstract: Technologies are generally provided for a pill dispensing device to track removal of a pill from a pill package. The device may include circuits printed/embedded on a composite sheet configured to be locally or completely flexible/stretchable with a multitude of slits corresponding to locations of pill containing cavities of the pill package. Composite sheet may include embedded rigid sections and be flexible near the slits. Additionally, top and/or bottom plates may further provide structural rigidity to achieve desired flexible behavior of the composite sheet. Electronic circuits printed/embedded on or in the composite sheet may detect removal of a pill from the pill package through the slits. Slits may include electrical contacts configured to switch a circuit corresponding to each slit between an active and an inactive state. Upon removal of the pill, the contacts may separate or touch each other, opening or closing the circuit corresponding to the expanded slit.

Abstract: The present technology provides dynamic security code systems and method for their creation and use. The systems include a base layer including a first pattern and a sublimating compound layer including a plurality of materials selectively covering the base layer. In some embodiments, each of the plurality of materials is configured to sublimate at respective sublimation rates. The system further includes a shielding layer configured to shield the base layer and the sublimating compound layer to form a security code. The shielding layer can be configured to control a diffusion rate of the plurality of materials through the shielding layer such that the security code is changed.

Abstract: A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

Abstract: A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

Abstract: A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

Abstract: Technologies are generally provided for a pill dispensing device to track removal of a pill from a pill package. The device may include circuits printed/embedded on a composite sheet configured to be locally or completely flexible/stretchable with a multitude of slits corresponding to locations of pill containing cavities of the pill package. Composite sheet may include embedded rigid sections and be flexible near the slits. Additionally, top and/or bottom plates may further provide structural rigidity to achieve desired flexible behavior of the composite sheet. Electronic circuits printed/embedded on or in the composite sheet may detect removal of a pill from the pill package through the slits. Slits may include electrical contacts configured to switch a circuit corresponding to each slit between an active and an inactive state. Upon removal of the pill, the contacts may separate or touch each other, opening or closing the circuit corresponding to the expanded slit.

Abstract: A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

Abstract: The present technology provides dynamic security code systems and method for their creation and use. The systems include a base layer including a first pattern and a sublimating compound layer including a plurality of materials selectively covering the base layer. In some embodiments, each of the plurality of materials is configured to sublimate at respective sublimation rates. The system further includes a shielding layer configured to shield the base layer and the sublimating compound layer to form a security code. The shielding layer can be configured to control a diffusion rate of the plurality of materials through the shielding layer such that the security code is changed.