Abstract: The invention relates to an assay for identifying an agent that modulates the interaction of a mRNA with a target protein, e.g. HuR and to organic compounds of formula I wherein R1, R2 and R3 are as defined above and their use, e.g. as an inhibitor on the complex-formation of an ARE-containing mRNA and a target protein.

Abstract: The present invention provides for a method for identifying an agent that has an inhibitory effect on the complex-formation of an ARE-containing mRNA and an HuR protein.

Abstract: An electromagnetic selection device of a two-stage planetary gear set (1) having one input shaft (2) and one output shaft (3), one sun gear (8), one ring gear (11), one planet carrier (10) with planetary gears (9), one transmission housing (6) and one sliding sleeve (14) for switching one first gear in which the ring gear (11) can be coupled with the housing (6) and one second gear in which the ring gear (11) can be coupled with the sun gear (8), the sliding sleeve (14) being movable by way of one electromagnet consisting of magnet coils (22, 23) and one armature (24). It is proposed that the armature (24) be situated rotatably, but axially fixed, upon the sliding sleeve (14).

Abstract: A method for providing a labeled target protein or labeled target peptide in high purity, which method comprises the steps of a. contacting a chemical molecule, which chemical molecule comprises a target protein or a target peptide residue beside amino acid residues, spacer residues, and/or linker residues, an affinity tagging residue, and a labeling residue which labeling residue may be detected by physical means, with an affinity support, to obtain said chemical molecule bound to the affinity support via the affinity tag of the affinity tagging residue, b. removing impurities in the reaction mixture surrounding the affinity support to which the chemical molecule according to step a. is bound, and c. cleaving or eluting said chemical molecule from said affinity support; and compounds useful in such method. Such method is e.g. useful for (ultra) HTS-screening, especially spectroscopic HTS systems at single molecule resolution.

Abstract: An electromagnetic selection device of a two-stage planetary gear set (1) having one input shaft (2) and one output shaft (3), one sun gear (8), one ring gear (11), one planet carrier (10) with planetary gears (9), one transmission housing (6) and one sliding sleeve (14) for switching one first gear in which the ring gear (11) can be coupled with the housing (6) and one second gear in which the ring gear (11) can be coupled with the sun gear (8), the sliding sleeve (14) being movable by way of one electromagnet consisting of magnet coils (22, 23) and one armature (24). It is proposed that the armature (24) be situated rotatably, but axially fixed, upon the sliding sleeve (14).

Abstract: A screening assay for identifying an agent that modulates T cells.

Abstract: The present invention provides for a method for identifying an agent that has an inhibitory effect on the complex-formation of an ARE-containing mRNA and an HuR protein.

Abstract: The invention relates to new fluorescent dyes of formula (I) which can be used in high throughput screening both, on the solid phase as well as in homogeneous solution.

Abstract: The present invention is directed to an Assay for high capacity screening of substances interfering with the attachment of human IgE to its high affinity receptor and/or of substances capable of detaching already bound IgE from this receptor and for the differential analysis between autoimmune disorders and classical allergies.

Abstract: The invention relates to new fluorescent dyes of formula (I) 1

Abstract: The invention relates to new fluorescent dyes of formula (I) which can be used in high throughput screening both, on the solid phase as well as in homogeneous solution.

Abstract: A method for the enzymatic sequencing of DNA is disclosed which uses dideoxythio-nucleotides or dideoxyamino-nucleotides as terminators that are labeled with one or two fluorescent dyes coupled to the terminators either before or after polymerization. The dye labeled DNA fragments are separated in a single lane of a separation system and then the terminal bases of each of the fragments are identified by measuring the fluorescent lifetime of the dye attached to the terminators.