Patents by Inventor Manfred Kubbies

Manfred Kubbies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiophene Derivatives, Their Manufacture and Use as Pharmaceutical Agents
    Publication number: 20070232602
    Abstract: Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: June 13, 2005
    Publication date: October 4, 2007
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Ulrich Tibes
  • Styrylsulfonamides
    Patent number: 7208526
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: April 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Matthias Koerner, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Timothy Woodcock
  • Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
    Patent number: 7208506
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: April 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Thomas von Hirschheydt, Timothy Woodcock
  • N-monoacylated o-phenylenediamines
    Patent number: 7208491
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: April 24, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Simultaneous determination of cell proliferation inhibition activity and toxicity
    Patent number: 7202081
    Abstract: A method for the simultaneous determination of cell proliferation inhibition activity and cell toxicity (induction of cell death) of a substance using a proliferating mammalian cell sample as a test system.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: April 10, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernhard Goller, Manfred Kubbies
  • Oxime derivatives and their use as pharmaceutically active agents
    Patent number: 7173060
    Abstract: The present invention relates to compounds of formula I, their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates; the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds as inhibitors of histone deacetylase (HDAC) and therefore in the control or prevention of illnesses and disorders as mentioned above, or in the manufacture of corresponding pharmaceutical compositions.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: February 6, 2007
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
    Publication number: 20070010564
    Abstract: The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 11, 2007
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Thomas von Hirschheydt, Timothy Woodcock
  • Styrylsulfonamides
    Publication number: 20060270874
    Abstract: The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
    Type: Application
    Filed: April 28, 2006
    Publication date: November 30, 2006
    Inventors: Edward Boyd, Frederick Brookfield, Jonathan Gridley, Matthias Koerner, Manfred Kubbies, Raymond Lau, Ulrike Reiff, Georg Tiefenthaler, Wolfgang von der Saal, Timothy Woodcock
  • Arylene-carboxylic acid (2-amino-phenyl)-amide derivatives
    Patent number: 7098247
    Abstract: The present invention describes compounds of the general formula I as well as processes for their manufacture, pharmaceutical compositions containing them and methods for using these compounds and pharmaceutical compositions as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 29, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Mono-acylated o-phenylendiamines derivatives
    Patent number: 7071219
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A wherein Ar, R1, and R2 are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: July 4, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Mono-acylated o-phenylendiamines derivatives
    Publication number: 20060089403
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A: which are useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
    Type: Application
    Filed: December 6, 2005
    Publication date: April 27, 2006
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Oxime derivatives and their use as pharmaceutically active agents
    Publication number: 20040214880
    Abstract: The present invention relates to compounds of formula I, 1
    Type: Application
    Filed: March 31, 2004
    Publication date: October 28, 2004
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Simultaneous determination of cell proliferation inhibition activity and toxicity
    Publication number: 20040180390
    Abstract: A method for the simultaneous determination of cell proliferation inhibition activity and cell toxicity (induction of cell death) of a substance using a proliferating mammalian cell sample as a test system.
    Type: Application
    Filed: February 11, 2004
    Publication date: September 16, 2004
    Inventors: Bernhard Goller, Manfred Kubbies
  • Mono-acylated o-phenylendiamines derivatives
    Publication number: 20040162317
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula A 1
    Type: Application
    Filed: February 3, 2004
    Publication date: August 19, 2004
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • N-monoacylated o-phenylenediamines
    Publication number: 20040157841
    Abstract: Mono-acylated o-phenylendiamines derivatives of formula I 1
    Type: Application
    Filed: February 3, 2004
    Publication date: August 12, 2004
    Inventors: Georg Fertig, Frank Herting, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives
    Publication number: 20040138270
    Abstract: The present invention describes compounds of the general formula I 1
    Type: Application
    Filed: December 10, 2003
    Publication date: July 15, 2004
    Inventors: Georg Fertig, Frank Herting, Matthias Koerner, Manfred Kubbies, Anja Limberg, Ulrike Reiff, Michael Weidner
  • Antibodies against SEMP1(p23)
    Patent number: 6627439
    Abstract: Antibody binding to the SEMP1 antigen and characterized in that said antibody binds to SEMP1 in a manner equivalent to an antibody selected from the group of antibodies DSM ACC2458, DSM ACC2459, DSM ACC2461, and DSM ACC2463 is useful for cancer diagnosis and therapy.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: September 30, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thorsten Hoevel, Stefan Koch, Manfred Kubbies, Olaf Mundigl, Petra Rueger
  • Fanconi-gen II
    Publication number: 20030022858
    Abstract: The present invention concerns a pathophysiologically relevant gene associated with Fanconi anaemia (FA), a polypeptide coded thereby, an antibody directed against the polypeptide as well as the pharmaceutical applications of the nucleic acid, polypeptide and antibody.
    Type: Application
    Filed: July 19, 2002
    Publication date: January 30, 2003
    Inventors: Manfred Kubbies, Andreas Machl, Simone Planitzer
  • Antibodies against SEMP1 (p23)
    Publication number: 20020150574
    Abstract: Antibody binding to the SEMP1 antigen and characterized in that said antibody binds to SEMP1 in a manner equivalent to an antibody selected from the group of antibodies DSM ACC2458, DSM ACC2459, DSM ACC2461, and DSM ACC2463 is useful for cancer diagnosis and therapy.
    Type: Application
    Filed: June 21, 2001
    Publication date: October 17, 2002
    Inventors: Thorsten Hoevel, Stefan Koch, Manfred Kubbies, Olaf Mundigl, Petra Rueger
  • Fanconi-gene II
    Publication number: 20020086848
    Abstract: The present invention concerns a pathophysiologically relevant gene associated with Fanconi anaemia (FA), a polypeptide coded thereby, an antibody directed against the polypeptide as well as the pharmaceutical applications of the nucleic acid, polypeptide and antibody.
    Type: Application
    Filed: October 15, 2001
    Publication date: July 4, 2002
    Inventors: Manfred Kubbies, Andreas Machl, Simone Planitzer