Abstract: The present invention relates to an anti-GDF15 antibody and to a dosage regimen for the treatment of cancer in a human patient using the anti-GDF15 antibody. The present inventors identified a mechanism by which GDF-15 blocks adhesion and transgression of predominantly T-lymphocytes into tissues. Hence, a novel treatment approach has been established by the present invention that facilitates effector T cell entry into tumor tissue upon blockage of GDF-15 using the antibody of the present invention thereby allowing the treatment of cancer in human patients.

Abstract: The present invention relates to a method for ex vivo photodynamic treatment of cells. A cell preparation is incubated in a first medium having 5 ?M or less of a photosensitive compound. A population of cells in the cell preparation retains the photosensitive compound, for example, a salt of 2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid methyl ester. The first medium is then replaced with an extrusion medium to remove the photosensitive compound. The cell preparation is then illuminated in the extrusion medium to selectively kill the population of cells retaining the photosensitive compound, thereby creating an illuminated cell preparation.

Abstract: The present invention relates to a method for ex vivo photodynamic treatment of cells. A cell preparation is incubated in a first medium having 5 ?M or less of a photosensitive compound. A population of cells in the cell preparation retains the photosensitive compound, for example, a salt of 2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid methyl ester. The first medium is then replaced with an extrusion medium to remove the photosensitive compound. The cell preparation is then illuminated in the extrusion medium to selectively kill the population of cells retaining the photosensitive compound, thereby creating an illuminated cell preparation.

Abstract: The invention relates to a method for determination of the muzzle velocity of a projectile (2) when it emerges from the firing barrel (1) of a shoulder-held weapon. In order not to weaken the firing barrel, it is proposed that a transmitter (3) for transmission of signals be arranged on the end face of the firing barrel (1) and that two sensors (9, 10), which are arranged at a distance d from one another, be arranged in or on the projectile (2) in order to detect the signals transmitted by the transmitter (3) and that these sensors (9, 10) detect a pulse on flying past the transmitter (3), and that the muzzle velocity for the projectile (2) be determined from the time difference between the pulses detected by the two sensors (9, 10).

Abstract: The invention relates to a method for determination of the muzzle velocity of a projectile (2) when it emerges from the firing barrel (1) of a shoulder-held weapon. In order not to weaken the firing barrel, it is proposed that a transmitter (3) for transmission of signals be arranged on the end face of the firing barrel (1) and that two sensors (9, 10), which are arranged at a distance d from one another, be arranged in or on the projectile (2) in order to detect the signals transmitted by the transmitter (3) and that these sensors (9, 10) detect a pulse on flying past the transmitter (3), and that the muzzle velocity for the projectile (2) be determined from the time difference between the pulses detected by the two sensors (9, 10).

Abstract: This invention relates to isolated, stem-cell derived cell populations and methods of use thereof. Methods of use include genomic target identification, validation of conventionally obtained genomic targets using e.g. expression profiling, positional cloning and/or transgenic animals, lineage-specific and/or transgene-specific drug screening and pharmacogenomics analysis.

Abstract: This invention relates to isolated, stem-cell derived cell populations and methods of use thereof. Methods of use include genomic target identification, validation of conventionally obtained genomic targets using e.g. expression profiling, positional cloning and/or transgenic animals, lineage-specific and/or transgene-specific drug screening and pharmacogenomics analysis.

Abstract: A safety mounting system in a launching device for rockets also provides a safe rocket conveying device by virtue of an additional locking arrangement. The locking arrangement establishes a shape-mating connection between the rocket and a launch tube preferably by use of a pin engaging into a bore in the launch tube. Prior to launching of the rocket, the pin is retracted by a pyrotechnical power element. The firing ballistics of the rocket are not impaired by this additional safety feature.