Abstract: The invention relates to the use in vitro of a kit for diagnostics, more particularly therapy-accompanying diagnostics, relating to a transplant and/or for diagnostics, more particularly therapy-accompanying diagnostics, relating to an autoimmune disease and/or for diagnostics, more particularly therapy-accompanying diagnostics, relating to a tumor disease and/or for diagnostics, more particularly therapy-accompanying diagnostics, relating to a vaccination, wherein the kit has the following components: a blood collection container, a blood collection set or blood collection system including a blood collection container, a nutrient medium for blood, and at least one activator for activating blood cells, more particularly immune cells, and/or at least one inhibitor for inhibiting blood cells, more particularly immune cells, and/or at least one modulator for modulating blood cells, more particularly immune cells.

Abstract: The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell culture based on immune cells.

Abstract: The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture medium are examined.

Abstract: The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture medium are examined.

Abstract: The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture medium are examined.

Abstract: The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell culture based on immune cells.

Abstract: The present invention refers to a cell culture system especially for investigating the sensitizing, allergenic and/or irritating effect of substances, comprising a first and a second compartment that can communicate with each other via a permeable interlayer, whereby the first compartment has an epidermis model and the second a cell culture based on immune cells.

Abstract: The invention relates to a cell culture system, in particular for the preclinical testing of active substances, comprising a first and a second compartment which are in communication with one another via a separating layer between the first and the second compartment, the separation layer being permeable for cellularly secreted substances, wherein the first compartment includes a syntopic culture with tissue cells and immune cells and the second compartment includes a culture with blood cells. The invention further relates to a method in this regard and to a kit and uses for the preclinical testing of active substances.

Abstract: The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture medium are examined.

Abstract: A support plate for carrying out functional tests on biological cells possesses raised sections which are spatially separated from each other and on which at least one measuring point, from an array of measuring points, is in each case arranged, with the cells being able to interact and bind at the measuring points. Trapping molecules, to which the cells are able to bind by means of their cell surface molecules, are immobilized at the measuring points, with the measuring points being separated from each other by regions of the support plate at which the cells cannot be immobilized (FIG. 4).

Abstract: The invention relates to a method for the determination of the immune defence activity of blood by the stimulation of white cells in the whole blood, incubation of the whole blood, separation of the supernatant from the sediment and determination of the activity from the separated supernatant. he invention also relates to a test kit for performing the method and to the use of a suitable blood sampling system, particularly a syringe cylinder for this purpose.