Abstract: A method is for performing a high-throughput analysis, according to which processing simultaneously ensues in a continuous manner at a number of work stations. In order to improve the sample throughput, a support, which includes a multitude of spots, particularly a number of spot arrays, is used that is moved in a time manner through the work stations. The corresponding device includes a bio-chip arrangement having a multitude of spots, particularly a number of spot arrays that are arranged in an interspaced manner on a common support made of a flat material.

Abstract: A process is proposed for preparing a microarray including a multiplicity of analytical positions or spots and arranged on a support. The spots include probe molecules and a polymer which has been solidified to give a film. A spot is generated by applying an initially flowable spotting solution to the support, which solution includes a polymer and probe molecules, the polymer being solidified after application to the support. A spotting solution is further proposed which includes, in aqueous solution, probe molecules and a polymer which can be solidified in a non-free radical manner.

Abstract: A system with immobilized DNA is used in the fields of medicine, environmentology or criminology as an analytical tool in the analysis of nucleic acid. The immobilized DNA is provided with a biocatalytically active marker, such as an enzyme, an with an inhibitor substance which reversibly inhibits catalytic activity, or in addition to the immobilized biocatalytic marker, the immobilized DNA is provided with a substance which can reversibly inhibit the catalytic activity of the marker. Alternatively, an immobilized biocatalytically active marker can be provided with DNA as a scavenger which includes a substance as an inhibitor which can reversibly inhibit the activity of the marker. In another alternative, it is possible to use a complex including a molecule binding double-stranded DNA and a substance as an inhibitor which can reversibly inhibit the activity of the marker by interacting with the immobilized biocatalytically active marker.

Abstract: An analysis device that may be used in biochemical analyses includes a module in a first housing, including a chip support, a sensor chip and electrical contacts between the chip and the chip support. The chip is encapsulated so that the electrical contacts are insulated and the sensitive surface of the sensor chip remains accessible to a fluid to be tested. The module and the first housing form an exchangeable applicator or chip card with mocrofluidic components or functions and is inserted into a second housing that has an evaluation unit for reading and analyzing measured data.

Abstract: A microfluidic diagnosis kit used in biochemical analysis obtains a premeasured amount of reagents in an applicator for an analysis system. The required reagents are proportioned as non-volatile agents and a microfluidic system is provided, whereby the reagents are automatically dissolved in a solvent and fed to a sensor module to carry out measurement.

Abstract: Redox (re)cycling is improved in terms of the measurement technique in such a way that the redox potential created by a redox pair is measured on a reference electrode in an electroless manner. A configuration adapted to the method contains an electrode system having at least three electrodes: one working electrode, one counter electrode and one reference electrode. The reference electrode is arranged in such a way that it is adjacent to at least partial areas of the two other electrodes, and preferably, at an equal distance from the partial areas. In terms of redox recycling, the electrode system is suitable, for example, for detecting enzyme-coupled identification reactions, but also for measuring an oxygen partial pressure or hydrogen peroxide.

Abstract: A method for biochemical analysis uses a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. The reaction chambers are smaller than 1 &mgr;l, the reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. In the system the planar array has at least two reaction chambers for substances, whereby the reaction chambers are closed with the goal of preventing an exchange of substances.

Abstract: A biosensor is used for measuring principal metabolites in blood and other substances. The biosensor has a special structure formed of a two-layer enzymatic membrane with a considerably increased functionality compared with enzymatic membranes of the prior art.

Abstract: Method for calibrating gas measuring sensors for dissolved gasses and method for measuring the concentration of CO.sub.2 in blood with the assistance of such a calibration method two or more separate calibration fluids in which a gas to be measured is dissolved with respectively different partial pressures are employed. For simplification, another (i.e., a second) calibration fluid is produced from one (i.e., a first) calibration fluid by modifying the partial pressure of the first calibration fluid to a different value, preferably by material transport between the first fluid and a gas phase. Analysis equipment operating with this method, particularly for CO.sub.2 measurement of blood, become simpler, smaller and less expensive.