Patents by Inventor Manfred W. Baetscher

Manfred W. Baetscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha (1,3) galactosyl transferase negative swine
    Publication number: 20030014770
    Abstract: Transgenic swine in which the normal expression of &agr;(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal&agr;1-3Gal&bgr;1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
    Type: Application
    Filed: March 15, 2002
    Publication date: January 16, 2003
    Applicant: The General Hospital Corporation
    Inventors: Kenth T. Gustafsson, David H. Sachs, Manfred W. Baetscher
  • Porcine Oct-4 promoter
    Patent number: 6482937
    Abstract: The present invention provides for a method of isolating and/or propagating porcine stem cells, more specifically pluripotential porcine embryonic stem cells. The pluripotential cells are isolated and/or propagated by the use of a selectable marker gene which is inserted into the genetic material of the cells, and which permits the survival and growth of the porcine embryonic stem cells. The selectable marker gene is inserted so as to be regulated by a control or promoter polynucleotide sequence in the embryonic stem cells, for example the promoter polynucleotide sequence being the porcine Oct-4 promoter sequence of the present invention. The invention also provides for a transgenic pig which will constitute a source of the pluripotent cells.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: November 19, 2002
    Assignee: BioTransplant, Inc.
    Inventors: Manfred W. Baetscher, Donna E. Akiyoshi, Ruth A. Kaplan
  • &agr;(1,3) galactosyltransferase negative porcine cells
    Patent number: 6413769
    Abstract: Transgenic swine in which the normal expression of &agr;(1, 3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal&agr;1-3Gal&bgr;1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: July 2, 2002
    Assignees: University of London, The General Hospital Corporation
    Inventors: Kenth T. Gustafsson, David H. Sachs, Manfred W. Baetscher