Patents by Inventor Manickam Ravichandran

Manickam Ravichandran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monovalent vaccine formulation and a method for preparation thereof
    Patent number: 11957744
    Abstract: The present invention discloses a vaccine formulation in accordance with an illustrative embodiment. The formulation including a live attenuated cholera vaccine strain VCUSM14P; a vaccine medium having starch, cellulose, dextrose, and yeast extract; and a phosphate buffer saline.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: April 16, 2024
    Assignee: AIMST UNIVERSITY
    Inventors: Guruswamy Prabhakaran, Manickam Ravichandran, Kurunathan A/L Sinniah, Yean Yean Chan
  • MONOVALENT VACCINE FORMULATION AND A METHOD FOR PREPARATION THEREOF
    Publication number: 20230129062
    Abstract: The present invention discloses a vaccine formulation in accordance with an illustrative embodiment. The formulation including a live attenuated cholera vaccine strain VCUSM14P; a vaccine medium having starch, cellulose, dextrose, and yeast extract; and a phosphate buffer saline.
    Type: Application
    Filed: August 1, 2022
    Publication date: April 27, 2023
    Applicant: AIMST UNIVERSITY
    Inventors: Guruswamy PRABHAKARAN, Manickam RAVICHANDRAN, Kurunathan A/L SINNIAH, Yean Yean CHAN
  • MONOVALENT VACCINE FORMULATION AND A METHOD FOR PREPARATION THEREOF
    Publication number: 20220175905
    Abstract: The present invention discloses a vaccine formulation in accordance with an illustrative embodiment. The formulation including a live attenuated cholera vaccine strain VCUSM14P; a vaccine medium having starch, cellulose, dextrose, and yeast extract; and a phosphate buffer saline.
    Type: Application
    Filed: December 26, 2018
    Publication date: June 9, 2022
    Applicant: AIMST UNIVERSITY
    Inventors: Guruswamy PRABHAKARAN, Manickam RAVICHANDRAN, Kurunathan SINNIAH, Yean Yean CHAN
  • strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
    Patent number: 7838016
    Abstract: Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 E1 Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Universiti Sains Malaysia
    Inventors: Manickam Ravichandran, Syed Atif Ali, Nur Haslindawaty Abdul Rashid, Lalitha Pattabiraman, Zainul Fadziruddin Zainuddin
  • VIBRIO CHOLERAE STRAINS VCUSM1 AND VCUSM4, METHOD OF PRODUCING SAME, AND VACCINE DERIVATIVES THEREOF
    Publication number: 20080107691
    Abstract: Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 El Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
    Type: Application
    Filed: May 24, 2007
    Publication date: May 8, 2008
    Inventors: Manickam RAVICHANDRAN, Syed Atif ALI, Nur Haslindawaty Abdul Rashid, Lalitha PATTABIRAMAN, Zainul Fadziruddin ZAINUDDIN
  • Vibrio cholerae strains VCUSM1 and VCUSM4, method of producing same, and vaccine derivatives thereof
    Publication number: 20060099229
    Abstract: Metabolic auxotroph of Vibrio cholerae 0139 synonym Bengal which has a mutation in its hem A gene and which is not capable of synthesizing aminolevulinic acid (ALA) de novo and which is obtained from a parent strain originally isolated from a patient's coproculture having all the identifying characteristics of Vibrio cholerae 0139 synonym Bengal is described. In this strain the hem A gene is mutated by inserting a kanamycin resistant gene cassette. Another metabolic auxotroph of Vibrio cholerae 01 El Tor where the hem A gene is mutated by a frame shift mutation is disclosed. Methods of producing the strains are disclosed.
    Type: Application
    Filed: November 5, 2004
    Publication date: May 11, 2006
    Inventors: Manickam Ravichandran, Syed Ali, Nur Rashid, Lalitha Pattabiraman, Zainul Zainuddin
  • DNA sequence encoding the specific and antigenic outer membrane protein of salmonella typhi
    Publication number: 20020012668
    Abstract: The genetic material encoding for a specific outer membrane protein (OMP) of Salmonella typhi has been isolated and characterized. This genetic material (ST50) allows for the production of specific proteins/peptides/DNA/RNA for its use in diagnostics, detection of the bacteria S.typhi or in the production of vaccines for typhoid fever.
    Type: Application
    Filed: February 28, 2001
    Publication date: January 31, 2002
    Applicant: Universiti Sains Malaysia
    Inventors: Asma Binti Ismail, Ong Kok Hai, Manickam Ravichandran, Zainoodin S. A. Kader