Abstract: A microfluidic diagnostic device may comprise a fluid inlet to receive a fluid from a fluidic slot, a main microfluidic channel fluidly coupled to the fluid inlet, and a main microfluidic pump interposed between the fluid inlet and the main microfluidic channel to continuously circulate a fluid through the fluidic slot, fluid inlet, and main microfluidic channel wherein the width of the fluid inlet is different from the width of the main microfluidic channel. A diagnostic device, comprising a fluidic slot, a fluid inlet fluidly coupled to the fluidic slot, a main channel fluidly coupled to the fluid inlet, and an inlet pump interposed between the fluid inlet and channel wherein the cross-sectional area of the fluid inlet is relatively larger at least one point than the cross-sectional area of the channel.

Abstract: Provided in one example is an apparatus, including a substrate supporting a microfluidic channel, a bubble jet inertial pump supported by the substrate adjacent the microfluidic channel to pump fluid through the microfluidic channel and an optical sensor on a first side of the microfluidic channel. A light emitter on a second side of the microfluidic channel is to pass light across the microfluidic channel to the optical sensor.

Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.

Abstract: According to an example, a microfluidic apparatus may include a fluid slot, a foyer in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer, a sensor to detect a presence of a particle of interest in a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to receive information from the sensor, determine, from the received information, whether a particle of interest has passed through the channel, and control the actuator to expel fluid in the foyer through the nozzle based upon the determination.

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

Abstract: Example sensor apparatus for microfluidic devices and related methods are disclosed. In examples disclosed herein, a method of fabricating a sensor apparatus for a microfluidic device includes etching a portion of an intermediate layer to form a sensor chamber in a substrate assembly, where the substrate assembly has a base layer and the intermediate layer, and where the base layer comprises a first material and the intermediate layer comprises a second material different than the first material. The method includes forming a first electrode and a second electrode in the sensor chamber. The method also includes forming a fluidic transport channel in fluid communication with the sensor chamber, where the fluidic transport channel comprises a third material different than the first material and the second material.

Abstract: A microfluidic device can include: a channel; a fluid inlet to pass fluid into the channel from a reservoir; a sensor disposed in the channel; and a pump actuator disposed in the channel apart from the sensor to induce fluid flow into the channel.

Abstract: A microfluidic sensing device comprises a channel and an impedance sensor within the channel. The impedance sensor comprises a local ground and an electrode within the channel. The local ground and the electrode are to form an electric field region that is elongated along the channel.

Abstract: An apparatus includes a chamber, a nozzle connected to the chamber, a fluid driver proximate the driver to expel fluid from the chamber through the nozzle, a microfluidic passage, an inlet connecting the microfluidic passage and the chamber, a sensor proximate the inlet to sense fluid within a fluid sensing zone within the inlet, and a particle aggregation limiter to control aggregation of particles within the sensing zone.

Abstract: Examples herein provide a device. The device includes a sample delivery component, which includes: a reagent chamber to contain at least one reagent; a sample chamber to contain a fluid sample; and a delivery channel extending from the reagent chamber and in fluid communication with the sample chamber and an output port, wherein the delivery channel is conducive to mixing the at least one reagent and the fluid sample to form a mixture before the mixture reaches the output port and be discharged therefrom. The device includes a testing cassette detachable from the delivery component, which includes: an input port in fluid communication with a microfluidic reservoir, the input port to receive the discharged fluid sample from the output port; and a micro-fabricated integrated sensor in a microfluidic channel extending from the microfluidic reservoir.

Abstract: Examples herein provide a device. The device includes a testing cassette including: a microfluidic channel connecting an input port at a first end to at least one sensor area at a second end, the channel is to allow a blood sample to flow from the input port to the at least one sensor area; at least two electrodes; and a micro-fabricated integrated sensor, wherein when an electrical potential difference is applied over the blood sample, the sensor is to measure, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from the input port to the at least one sensor area and begin to coagulate, thereby obtaining a measurement function as a function of time. The device includes a processor to correlate the measurement function to a characteristic of the blood sample.

Abstract: A system and method for managing a microfluidics device. The system includes a microfluidics device; a controller with a first processor which receives outputs from the microfluidics device and provides inputs to the microfluidics device; and a computing device with a second processor and an application program interface (API). The computing device provides instructions to the controller using the API. The instructions are executed by the first processor to produce real-time outputs to the microfluidics device.

Abstract: A controller is connected to controlled devices on a microfluidic chip with a multiplexer. Signal transmission band width is differently allocated amongst the plurality of controlled devices on the microfluidic chip.

Abstract: A device including a substrate and a channel formed in a layer disposed on the substrate. The layer includes a cavitation layer and a passivation layer to mitigate the effects of hydrodynamic cavitation on a surface of the channel. The passivation and cavitation material and thickness are optimized thermally to nucleate and eject a bubble at low voltages. A resistive heating element is disposed within the channel that is activated to create a micro-fluidic pump to advance a fluid through the channel. A sensor is disposed within the channel to measure a characteristic of the fluid passing through the channel.

Abstract: A microfluidic diagnostic chip may, in an example, include a number of microfluidic channels defined in a substrate each microfluidic channel fluidly coupled to at least one fluidic slot; the at least one fluidic slot to receive a number of fluids, and a number of gold sensors each gold sensor having a thickness of between 1500 and 5000 angstroms (?).

Abstract: An apparatus includes a microfluidic passage, a chamber, an inlet connecting the microfluidic passage to the chamber, a sensor proximate the inlet to sense fluid within the inlet, a first nozzle, a first fluid driver to move fluid through the first nozzle to draw fluid across the inlet, a second nozzle, a second fluid driver to move fluid through the second nozzle to draw fluid across the inlet and a controller. The controller sequentially actuates the first fluid driver and the second fluid driver.

Abstract: Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows. The method includes measuring, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from a first end and coagulates at a second end of the microfluidic channel to obtain a measurement function as a function of time. The method also includes correlating the measurement function to a characteristic of the blood sample.

Abstract: Provided herein are a system and method for using a microfluidics device. The system includes: a plurality of pumps and a plurality of sensors; a first communication line to select a pump from the plurality of pumps and select a sensor from the plurality of sensors; a second communication line selectively connected to the selected pump; and a third communication line selectively connected to the selected sensor.

Abstract: Provided in one example is an apparatus, including a substrate supporting a microfluidic channel, a bubble jet inertial pump supported by the substrate adjacent the microfluidic channel to pump fluid through the microfluidic channel and an optical sensor on a first side of the microfluidic channel. A light emitter on a second side of the microfluidic channel is to pass light across the microfluidic channel to the optical sensor.

Abstract: A device includes a microfluidic channel structure on a substrate and a first resistive structure on the substrate to control the temperature of at least the substrate. The first resistive structure is separate from, and independent of the, microfluidic channel structure. In some instances, the device includes a second resistive structure.