Abstract: A wireless, web based system for monitoring patient drug compliance includes a plastic container that holds a wireless device, the patient's drugs, and a cpu programmable remotely and automatically from normal computer input by health care providers and pharmacists to control the functioning of the wireless transceiver and a variety of sound, vibration, light and readable screen for reminders and to provide drug related information. A sensor detects and wirelessly reports the opening of the medicine container in real time to remind the patient, when noncompliance occurs, on the patient's portable device and also telephones or pages. the patient as additional reminders. The web site program analyzes models and interprets the data to provide important drug non-compliance information to healthcare professionals.