Patents by Inventor Manoj Ramakrishna
Manoj Ramakrishna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11566218Abstract: Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.Type: GrantFiled: June 22, 2017Date of Patent: January 31, 2023Assignee: Global Life Sciences Solutions USA LLCInventors: Nagaraju Konduru, Manoj Ramakrishna, Haresh Digambar Patil
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Patent number: 11525112Abstract: Disclosed is a cell culture system comprising a first cell culture bioreactor system (10) for culturing cells to a predetermined cell density or quantity, the system including a bioreactor volume (20), a process controller (30), process control devices (32) which provide inputs (16) for the culture volume and culture parameter measurement devices (14), wherein the process controller is operable according to plural control program steps to control the process devices to provide inputs for a suitable cell culture environment in the bioreactor volume, and is further operable according to control program steps modified by feedback values from the culture parameter measurement devices, and comprises a memory (36) operable to record data indicative of the progress of the control program steps.Type: GrantFiled: December 22, 2017Date of Patent: December 13, 2022Assignee: Global Life Sciences Solutions USA LLCInventors: Manoj Ramakrishna, Anoop Bhargav, Umesh Pai
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Patent number: 11452976Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.Type: GrantFiled: December 22, 2017Date of Patent: September 27, 2022Assignee: Global Life Sciences Solutions USA LLCInventors: Manoj Ramakrishna, Sebastian John, Anoop Bhargav, Haresh Digambar Patil, Praveen Paul
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Patent number: 10995312Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary, Pradeep Kumar, Anoop Bhargav, Sebastian John, Nivedita Phadke, Manoj Ramakrishna
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Patent number: 10995310Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Patent number: 10934518Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.Type: GrantFiled: January 29, 2016Date of Patent: March 2, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Haresh Digambar Patil, Manoj Ramakrishna, Anoop Bhargav, Praveen Paul, Sebastian John, Swapnil Puranik
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Publication number: 20200411743Abstract: The present invention provides thermoelectric composite materials that comprise a physical mixture of semiconducting polymers and carbon nanotube structures. The present invention further provides a process to improve the thermoelectric power factor of the composite by doping with inorganic salts.Type: ApplicationFiled: September 16, 2019Publication date: December 31, 2020Applicants: Council of Scientific and Industrial Research, GAIL INDIA LIMITEDInventors: Biswapriya Deb, Vijayakumar Chakkooth, Vijitha Ignatious, Manoj Ramakrishna Meshram, Jaivinder Singh, Tanjore Puli Yuvaraj
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Patent number: 10858622Abstract: The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.Type: GrantFiled: August 12, 2016Date of Patent: December 8, 2020Assignee: Global Life Sciences Solutions USA LLCInventors: Manoj Ramakrishna, Haresh Digambar Patil, Sebastian John
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Publication number: 20190388855Abstract: The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.Type: ApplicationFiled: December 22, 2017Publication date: December 26, 2019Inventors: Manoj Ramakrishna, Sebastian John, Anoop Bhargav, Haresh Digambar Patil, Praveen Paul
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Publication number: 20190338231Abstract: Disclosed is a cell culture system comprising a first cell culture bioreactor system (10) for culturing cells to a predetermined cell density or quantity, the system including a bioreactor volume (20), a process controller (30), process control devices (32) which provide inputs (16) for the culture volume and culture parameter measurement devices (14), wherein the process controller is operable according to plural control program steps to control the process devices to provide inputs for a suitable cell culture environment in the bioreactor volume, and is further operable according to control program steps modified by feedback values from the culture parameter measurement devices, and comprises a memory (36) operable to record data indicative of the progress of the control program steps.Type: ApplicationFiled: December 22, 2017Publication date: November 7, 2019Inventors: Manoj Ramakrishna, Anoop Bhargav, Umesh Pai
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Publication number: 20190309254Abstract: Cell culture apparatus is disclosed comprising: a cell culture container comprising a flexible tube; a support table; and a pair of opposed holders for holding opposed portions of the tube in a fluid tight manner such that fluid cannot pass through the respective portion inside the tube, the spacing between the said pair being adjustable to provide an adjustable sealed volume in the tube between the holder pair.Type: ApplicationFiled: June 22, 2017Publication date: October 10, 2019Inventors: Nagaraju Konduru, Manoj Ramakrishna, Haresh Digambar Patil
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Patent number: 10393709Abstract: A holding system for holding and hoisting a chromatography column of one or more chromatography columns is disclosed. The holding system includes an upright member and a plurality of holding members movably arranged along the upright member. A first supporting member is positioned at an end portion of the chromatography column, wherein a holding member of the plurality of holding members is configured to be engaged to the first supporting member. A second supporting member is positioned at another end portion of the chromatography column. A holding member of the plurality of holding members is configured to be engaged to the second supporting member. One or more hoist assisting members may be also present. A hoist assisting member is operatively connected to the holding member engaged to the first supporting member. The hoist assisting member is operable to move the holding member connected to the first supporting member for hoisting the chromatography column.Type: GrantFiled: March 30, 2015Date of Patent: August 27, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Manoj Ramakrishna, Kishore Chengalvarayan, Nikhil Kamble
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Patent number: 10315134Abstract: The invention relates to a chromatography column assembly that offers an affordable self-packed column for performing chromatographic separation. The chromatography column assembly comprises a column tube having a first and a second opening at substantially opposite ends, and an end cap of either a snap fit design or a bolted design. The column assembly may further include an adaptor shaft inserted into the column through the end cap for achieving a desired bed volume. The column assembly may also include a second end cap enclosing the second opening, and an optional adaptor shaft may be inserted into the column through the second end cap, enabling further adjustment of the bed volume.Type: GrantFiled: August 15, 2014Date of Patent: June 11, 2019Assignee: GE Healthcare Bio-Science ABInventors: Veena Rao, Manoj Ramakrishna, Nikhil Kamble
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Patent number: 10183447Abstract: The invention discloses an apparatus for aligning and supporting a first and a second length of thermoplastic tubing, preparatory to and during cutting and welding of said lengths of tubing, that includes a first holder arranged to accommodate portions of the first and second lengths of tubing in a first and a second elongated holding space respectively, a second holder arranged to accommodate portions of the first and second lengths of tubing in a third and a fourth elongated holding space respectively, and movable in a direction essentially perpendicular to the holding spaces of the first and second holders from a cutting position, a cutting means arranged between said first and second holders for cutting said lengths of tubing when the second holder is in the cutting position and an aligning means to align these lengths of tubing with each other.Type: GrantFiled: October 22, 2014Date of Patent: January 22, 2019Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Kishore Chengalvarayan, Manoj Ramakrishna
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Publication number: 20190017011Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; at least a fluid handling portion 48,49 of at least one fluid pump device 54/58; and at least one connection 43 for connecting to a conduit and/or path for carrying fluids, gas and/or electricity.Type: ApplicationFiled: August 25, 2016Publication date: January 17, 2019Applicant: General Electric CompanyInventors: Haresh Digambar Patil, Praveen Paul, Manish Uddhaorao Choudhary, Pradeep Kumar, Anoop Bhargav, Sebastian John, Nivedita Phadke, Manoj Ramakrishna
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Publication number: 20180251715Abstract: Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell (41) to determine changes in the mass load on the tray.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Publication number: 20180250666Abstract: Disclosed is biomanufacturing apparatus (1) comprising a housing (20), a substantially enclosed bioreactor chamber (30) inside the housing and a further substantially enclosed region (36) inside the housing containing electrical parts and/or electronic control components, the chamber (30) including: a tray (40) for supporting a bioreactor, a tray support (45) including a mechanism (44,47) for rocking the tray in use the tray (40) including a heater (42) for contacting a bioreactor and heating the same, and the apparatus further comprising secondary heating (53) for heating air surrounding the tray.Type: ApplicationFiled: August 25, 2016Publication date: September 6, 2018Applicant: General Electric CompanyInventors: Praveen Paul, Manoj Ramakrishna, Anoop Bhargav, Haresh Digambar Patil, Sebastian John, Manish Uddhaorao Choudhary, Pradeep Kumar, Nivedita Phadke
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Publication number: 20180201894Abstract: The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.Type: ApplicationFiled: August 12, 2016Publication date: July 19, 2018Inventors: Manoj RAMAKRISHNA, Haresh Digambar PATIL, Sebastian JOHN
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Publication number: 20180002655Abstract: The present invention relates to a novel bioreactor system for cell cultivation. More specifically, the invention relates to a compact bioreactor system which has several integrated functions and enables small scale static culture as well as scale-up rocking culture in the same bioreactor. The bioreactor system comprises tray for positioning of a cell culture bag having adjustable volume, a lid covering the cell culture bag and provided with heating function, an integrated perfusion unit, an integrated cell loading unit, and an integrated unit for automatic cell culture sampling, wherein the bioreactor system is controlled by a single control unit. The invention also relates to a method of cell culture using the bioreactor system for culture of therapeutic cells.Type: ApplicationFiled: January 29, 2016Publication date: January 4, 2018Inventors: Haresh Digambar Patil, Manoj Ramakrishna, Anoop Bhargav, Praveen Paul, Sebastian John, Swapnil Puranik
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Publication number: 20170030872Abstract: A holding system for holding and hoisting a chromatography column of one or more chromatography columns is disclosed. The holding system includes an upright member and a plurality of holding members movably arranged along the upright member. A first supporting member is positioned at an end portion of the chromatography column, wherein a holding member of the plurality of holding members is configured to be engaged to the first supporting member. A second supporting member is positioned at another end portion of the chromatography column. A holding member of the plurality of holding members is configured to be engaged to the second supporting member. One or more hoist assisting members may be also present. A hoist assisting member is operatively connected to the holding member engaged to the first supporting member. The hoist assisting member is operable to move the holding member connected to the first supporting member for hoisting the chromatography column.Type: ApplicationFiled: March 30, 2015Publication date: February 2, 2017Inventors: Manoj Ramakrishna, Kishore Chengalvarayan, Nikhil Kamble