Patents by Inventor Manuel CASES

Manuel CASES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS
    Publication number: 20230374143
    Abstract: The present invention relates to the use of sortilin antagonists, in particular compounds of Formula (I), (II), (III), and (IV), in the treatment or prevention of hearing loss. Also provided are pharmaceutical compositions comprising the sortilin antagonists herein disclosed and methods for the treatment or prevention of hearing loss in a subject in need thereof.
    Type: Application
    Filed: October 7, 2021
    Publication date: November 23, 2023
    Inventors: Mads Fuglsang KJØLBY, Anders NYKJÆR, Paul LITTLE, Manuel CASES
  • Morpholine derivatives as norepinephrine reuptake inhibitors
    Publication number: 20070083046
    Abstract: Compounds of the general formula (1) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
    Type: Application
    Filed: October 28, 2004
    Publication date: April 12, 2007
    Applicant: Eli Lilly and Company
    Inventors: Gordan Campbell, Manuel Cases-Thomas, Teresa Man, John Masters, Helene Eugenie Rudyk, Magnus Walter
  • 3-Aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
    Publication number: 20070066663
    Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).
    Type: Application
    Filed: May 25, 2004
    Publication date: March 22, 2007
    Applicant: ELI LILLY AND COMPANY
    Inventors: Christopher Beadle, Manuel Cases-Thomas, Barry Clark, Peter Gallagher, John Masters, Graham Timms, Magnus Walter, Maria Whatton, Virginia Wood, Jeremy Gilmore
  • Inhibitors of monomine uptake
    Publication number: 20060079554
    Abstract: N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
    Type: Application
    Filed: November 25, 2003
    Publication date: April 13, 2006
    Inventors: Peter Barry, Manuel Cases-Thomas, Peter Gallagher, Jeremy Gilmore, John Masters, Graham Timms, Maria Whatton, Virginia Wood
  • Aryl and heteroaryl morpholine derivatives
    Publication number: 20060003998
    Abstract: Compounds of formula (I) wherein Rx is H; Ry is H or C1-C4 alkyl; each Rz is independently H or C1-C4 alkyl; X represents O; Y represents OH or OR; R is C1-C4 alkyl; and Ar1 and Ar2 are optionally substituted phenyl or 5- or 6-membered heteroaryl rings are selective inhibitors of the reuptake of norepinephrine.
    Type: Application
    Filed: August 18, 2003
    Publication date: January 5, 2006
    Applicant: ELI LILLY AND COMPANY
    Inventors: Manuel Cases-Thomas, Helen Haughton, Robin Simmonds, Helene Rudyk, Magnus Walter, Sivi Ouwerkerk-Mahadevan