Abstract: A solar module having on the front a cover plate with an outer surface and an inner surface is described. An optical interference layer for reflecting light within a predefined wavelength range is arranged on the inner surface. The inner surface and/or the outer surface have a patterned region. The patterned region has a height profile with hills and valleys, and a portion of the patterned region is composed of flat segments that are inclined relative to a plane of the cover plate.

Abstract: A plate-shaped component includes a transparent cover plate and a planar back element attached to the cover plate. The cover plate has a front surface facing the external environment and a back surface facing the back element. At least one surface selected from the front and back surfaces has at least one structured region, and at least one color filter layer for reflecting light within a predetermined wavelength range is arranged on the at least one surface selected from the front and back surfaces. The at least one structural region is perpendicular to the plane of the cover plate. The at least one color filter layer includes at least one refractive layer having a refractive index of greater than 2.5 in the wavelength range from 400 nm to at least 700 nm and an extinction coefficient of at least 0.2 below 450 nm and less than 0.2 above 700 nm.

Abstract: Disclosed herein are compositions and methods to prevent Plasmodium parasites from evading host cell autophagy responses, including by blocking binding of Plasmodium Upregulated in infective sporozoites 3 (UIS3) to host cell autophagy proteins, such as Microtubule-associated protein 1A/1B-light chain 3 (LC3).

Abstract: A tracking device includes a housing that can be mounted to a patient or a prosthetic device or orthotic device of the patient. The tracking device can include communications circuitry, a position sensor, and processing circuitry. The position sensor is configured to detect position data regarding the patient. The processing circuitry is configured to receive the position data from the position sensor, determine one or more metrics regarding activity of the patient based on the position data, and use the communications circuitry to transmit at least one of the position data or the one or more metrics to a client device via the cellular network.

Abstract: A solar module having on the front a cover plate with an outer surface and an inner surface is described. The outer surface has a patterned region, on which an optical interference layer for reflecting light within a predefined wavelength range is arranged. The patterned region has a height profile with hills and valleys, and a portion of the patterned region is composed of flat segments that are inclined relative to a plane of the cover plate.

Abstract: A solar module having on the front a cover plate with an outer surface and an inner surface is described. An optical interference layer for reflecting light within a predefined wavelength range is arranged on the inner surface. The inner surface and/or the outer surface have a patterned region. The patterned region has a height profile with hills and valleys, and a portion of the patterned region is composed of flat segments that are inclined relative to a plane of the cover plate.

Abstract: Pharmaceutical compositions and methods for the treatment of malaria are presented. Such compositions and methods may target energy-sensing pathways of the malaria parasite, Plasmoclium, of parasite host cell, or both. The compositions, in certain aspects of the present invention, target a signalling pathway involving the host AMP-protein activated kinase (AMPK) and/or the parasite AMPK homologue, KIN, which controls parasite replication and virulence.

Abstract: A method for inducing protective immunity in a vertebrate host against malaria, by administering to the host a live rodent Plasmodium organism and exploiting its cross-species protection potential. A method to use genetically engineered live rodent Plasmodium organisms expressing antigens from different stages of the life cycle of human-infective Plasmodium species to immunize vertebrate hosts against malaria. The invention further provides for the production of a vaccine composition, by suspending wild-type or genetically modified rodent Plasmodium organisms in a suitable pharmaceutically acceptable carrier solution.

Abstract: A method for inducing protective immunity in a vertebrate host against malaria, by administering to the host a live rodent Plasmodium organism and exploiting its cross-species protection potential. A method to use genetically engineered live rodent Plasmodium organisms expressing antigens from different stages of the life cycle of human-infective Plasmodium species to immunize vertebrate hosts against malaria. The invention further provides for the production of a vaccine composition, by suspending wild-type or genetically modified rodent Plasmodium organisms in a suitable pharmaceutically acceptable carrier solution.

Abstract: Identifying changes between network data processing systems is provided. A first number of attributes for a network data processing system are identified by a processor unit. A second number of attributes for a number of potential network data processing systems are identified by the processor unit. A graphical user interface with a graphical representation of a comparison of the first number of attributes and the second number of attributes is displayed on a display device.

Abstract: Upgrading a multi-tiered application is provided. In response to receiving a request to upgrade a multi-tiered application, wherein components of the multi-tiered application are deployed across a plurality of virtual machines, an appropriate integrated patch is selected for the upgrade. The selected integrated patch includes an integrated set of patches for the components of the multi-tiered application, state update data, and order constraints. The components of the multi-tiered application specified in the selected integrated patch are upgraded by using the integrated set of patches and order constraints. In addition, the state of the components of the multi-tiered application are updated by using the state update data. Then, the updated state of the multi-tiered application is saved to storage.

Abstract: Identifying traffic patterns to web sites based on templates that characterize the arrival of traffic to the web sites is provided. Based on these templates, determinations are made as to which web sites should be co-located so as to optimize resource allocation. Web sites whose templates are complimentary, i.e. a first web site having a peak in arrival traffic at time t1 and a second web site that has a trough in arrival traffic at time t1, are designated as being candidates for co-location. In addition, the templates identified for the traffic patterns of web sites are used to determine thresholds for offloading traffic to other servers. These thresholds include a first threshold at which offloading should be performed, a second threshold that takes into consideration the lead time needed to begin offloading, and a third threshold that takes into consideration a lag time needed to stop offloading of traffic.

Abstract: An on-demand manager provides an improved distributed data processing system for facilitating dynamic allocation of computing resources among multiple domains based on a current workload and service level agreements. Based on a service level agreement, the on-demand manager monitors and predicts the load on the system. If the current or predicted load cannot be handled with the current system configuration, the on-demand manager determines additional resources needed to handle the workload. If the service level agreement violations cannot be handled by reconfiguring resources at a domain, the on-demand manager sends a resource request to other domains. These other domains analyze their own commitments and may accept the resource request, reject the request, or counter-propose with an offer of resources and a corresponding service level agreement.

Abstract: An interactive sound system is provided. The interactive sound system includes a plurality of sound channels arranged in a hierarchy, a representation of real space, a visual arrangement of the plurality of sound channels over the representation of real space, a user interface for simultaneous management of more than one sound channel in parallel, and a processing module. The processing module is configured to apply a user-attributed behavior to a sound channel over a hierarchically transmitted behavior, automatically assign a behavior to a sound channel following the activation of an automatic trigger, accept a manual assignment of a behavior to a sound channel following the activation of a human-operated trigger, and override a sound channel with an alarm behavior.

Abstract: Techniques are disclosed for network distribution and provisioning of applications, such as transactional applications and parallel applications, across multiple administrative domains that ensure compliance with service level agreements. For example, a method of provisioning one or more resources in a distributed computing network to ensure compliance with a service level agreement associated with a computer application includes the following steps. Network performance is monitored between a local domain and one or more cooperating domains connected to the local domain by network paths. A present or predicted violation of the service level agreement is identified based on at least a portion of results of the monitoring step. One or more cooperating domains are selected that can effect compliance with the service level agreement by instantiating one or more network resources within at least one of the selected cooperating domains in response to a request from the local domain.

Abstract: Deploying a set of virtual software resource templates to a plurality of nodes is provided. The process identifies a set of virtual machine images and metadata to form a set of virtual software resource templates. The process creates a model that indicates a performance metric based on a number of nodes on which a number of virtual machine images is deployed. The process receives a quality of service requirement. The process determines, using the model, a sufficient number of virtual software resource templates in the set of virtual software resource templates and a sufficient number of nodes in the plurality of nodes to fulfill the quality of service requirement. The process deploys the sufficient number of virtual software resource templates on the sufficient number of nodes using the metadata.

Abstract: An image analysis system provides for importing, normalizing and co-registering a plurality of ocular fundus images, or images obtained by their decomposition, analysis, processing, or synthesis. Differences between the image are determined and of those differences those that are meaningful (e.g., from a diagnostic point of view) are highlighted. Sequences of these differences, which reflect changes in the eye represented in the images, are synthesized so as to present a view of how the differences manifest over time. Structures of importance in the eye are overlapped so that the information may be presented in a meaningful fashion for diagnostic purposes.

Abstract: Techniques for selectively off-loading workload across multiple data centers are disclosed. For example, a technique for processing a user request in accordance with a multiple data center environment comprises the following steps/operations. A user request is obtained at a first data center. The user request is classified based on one or more classification criterion. At least a portion of a workload associated with the classified user request is off-loaded to at least a second data center to be processed, wherein the off-loading step/operation is at least based on one or more administrative policies associated with at least one of the first data center and the second data center. The workload is processed such that the user request is at least substantially satisfied in accordance with a service level agreement for the requesting user.

Abstract: The present invention provides a method, apparatus, and computer implemented instructions for processing Web and other Internet or Intranet based services. The system for processing Web requests includes a Web server with a connection to the Internet or Intranet with a predefined network bandwidth, a set of primary Web and application server cluster nodes to process the requests, and a dispatcher to allocate requests to nodes; in addition, one or more offload server nodes are connected to the network. Client Web requests arrive at the dispatcher of the Web server, which determines whether the incoming request can be handled at the primary Web server cluster, whether all or part of the user Web request should be offloaded to one of the offload server nodes, or whether the request should be throttled.

Abstract: A method, system, computer program product, and data structure for processing requests for services in a networked data processing system is provided. In one embodiment a request is received by a service provider. The request includes defined allowable actions and request definition compositions. The request also includes a plurality of actions wherein the relationships between the plurality of actions are defined. The service provider processes the plurality of actions according to the defined relationships and generates a response.