Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: A coil for a transformer core comprises a longitudinal axis, at least one multi-stranded conductor, at least one first conductor turn wound around the longitudinal axis, at least one second conductor turn wound around the longitudinal axis, the at least one first conductor turn being adjacent the at least one second conductor turn. Each of the at least one first and second conductor turns is provided with an electrically insulating member which extends about part but not an entire cross-sectional perimeter of the respective conductor turn, such that the at least one first and second conductor turns are insulated against each other. The electrically insulating member does not extend the entire cross-sectional perimeter of the respective conductor turn.

Abstract: The present disclosure relates to wind turbines comprising a tower, a nacelle mounted on the tower, a wind turbine rotor with a plurality of blades, and a wind turbine generator operatively coupled with the wind turbine rotor. The wind turbine further comprise one or more auxiliary wind energy converters arranged with the nacelle. The present disclosure further relates to methods for providing power to an auxiliary system of a wind turbine.

Abstract: This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: Piezoelectric devices and methods and apparatus for producing piezoelectric devices. Such a method includes printing a poly(vinylidene fluoride) (PVdF) film having a first side and a second side to form a dielectric, printing a first electrode on the first side of the PVdF film, and printing a second electrode on the second side of the PVdF film. An apparatus for producing a piezoelectric device includes a corona poling apparatus having an anode with an electrically conductive ionizer needle, a cathode spaced apart from and facing the ionizer needle, and a shield surrounding the ionizer needle. The shield focuses ions created during corona discharge toward a location between the ionizer needle and the cathode.

Abstract: Capacitive sensors and methods and apparatuses for producing capacitive sensors. Such a method includes printing a dielectric layer to include a poly(vinylidene fluoride) (PVdF) film so that the dielectric layer has oppositely-disposed first and second surfaces. First and second electrodes are provided on the first and second surfaces, respectively, of the dielectric layer. A corona poling apparatus for producing a capacitive sensor includes an anode having at least one electrically conductive ionizer needle, a cathode opposite and facing the anode with a distance therebetween, a sample location defined between the ionizer needle and the cathode wherein the sample location is configured to receive an object to be polarized, and a shield surrounding at least one of the anode, the ionizer needle, and the cathode. The shield focuses ions created during a corona discharge between the anode and the cathode toward the sample location.

Abstract: The disclosed technology is generally directed to code transparency. In one example of the technology, raw input data that includes version information that is associated with code is received. The version information includes pull requests associated with the code. Extracted key phrases are provided by performing a key-phrase extraction on the raw input data. A list of documents and a list of people are determined based at least in part on the extracted key phrases. A relevance ranking is performed on the list of documents and the list of people. Based on the relevance ranking, relevant documents and relevant people are determined, such that the relevant documents and the relevant people are relevant to the code. To a developer environment that is associated with the code, information associated with the relevant documents and/or the relevant people is provided.

Abstract: The invention provides compounds of Formula (I) for inhibiting glycosidases, pro drugs of the compounds, and pharmaceutical compositions comprising the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of OGA, accumulation or deficiency of O-GlcNAc.

Abstract: This invention pertains to biotechnology, more specifically to the field of human health. This document describes in particular conjugates of the SARS-CoV-2 receptor binding domain covalently conjugated to a carrier protein, the method used to obtain them, and the vaccine compositions that contain them. The vaccine compositions described in this invention are useful for the prevention of the SARS-CoV-2 infection as they induce a strong response of neutralizing antibodies.

Abstract: Described herein is a system and method for determining one or more data modulation profiles for one or more devices. The system and method described herein may measure signal quality, such as a modulation error ratio (MER), signal-to-noise ratio (SNR), receive power, transmit power, etc. Based on the signal quality, the system may determine one or more data modulation profile(s) (e.g., quadrature amplitude modulation (QAM) profiles) for a subcarrier, a plurality of subcarriers, a device, and/or a grouping of devices.

Abstract: An ADC system comprises a coarse ADC for determining a coarse word representing an input signal, and an incremental ADC for determining a fine word based on a combination of the input signal and a feedback signal. A first combiner generates a first intermediate output word by joining the coarse word and the fine word. A feedback path generates the feedback signal based on the first intermediate output word. A decimation filter generates a second intermediate output word by filtering the first intermediate output word. A correction block determines a correction word based on the coarse word, on the first and the second predetermined number of bits and conversion parameters of the incremental ADC. A second combiner generates an output word by addition of the second intermediate output word and the correction word.

Abstract: A capacitance to digital converter, CDC, has a first and a second reference terminal for receiving first and second reference voltages, a reference block comprising one or more reference charge stores and being coupled to the first and second reference terminals via a first switching block, a scaling block for providing at third and fourth reference terminals downscaled voltages from the first and second reference voltages depending on a scaling factor, first and second measurement terminals for connecting a capacitive sensor element, the first measurement terminal being coupled to the third and fourth reference terminals via a second switching block, and a processing block coupled to the reference block and to the second measurement terminal and being configured to determine a digital output signal based on a charge distribution between the sensor element and the reference block and based on the scaling factor, the output signal representing a capacitance value of the sensor element.

Abstract: One embodiment of the present invention sets forth a technique for generating audio for a speaker system. The technique includes receiving an audio input signal, a first location associated with the audio input signal, a first geometric model of the speaker system, and a second geometric model of one or more surfaces in proximity to the speaker system. The technique also includes generating a plurality of output signals for a plurality of speaker drivers in the speaker system based on the audio input signal, the first location, and the first and second geometric models. The technique further includes transmitting the plurality of output signals to the plurality of speaker drivers, wherein the plurality of speaker drivers emit audio that corresponds to the plurality of output signals, the emitted audio rendering a sound corresponding to the audio input signal at the first location.

Abstract: 1H-pyrazolo[4,3-g]isoquinoline and 1H-pyrazolo[4,3-g]quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).

Abstract: Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.

Abstract: A safety brake system (40; 240) for use in a conveyance system. The safety brake system (40; 240) includes a guide rail (20) and a conveyance component moveable along the guide rail (20). The safety brake system (40; 240) includes a safety brake (42; 242), a linkage mechanism (56; 256) and an actuator (44; 144; 244) for the safety brake (42; 242). The safety brake (42; 242) is moveable between a non-braking position where the safety brake (42; 242) is not in engagement with the guide rail (20) and a braking position where the safety brake (42; 242) is engaged with the guide rail (20). The actuator (44; 144; 244) is configured to be mounted to the conveyance component and positioned between first and second ferromagnetic components. The actuator includes an array of magnetic components including a first magnetic component adjacent to and arranged between two second magnetic components.

Abstract: An ADC system comprises a coarse ADC for determining a coarse word representing an input signal, and an incremental ADC for determining a fine word based on a combination of the input signal and a feedback signal. A first combiner generates a first intermediate output word by joining the coarse word and the fine word. A feedback path generates the feedback signal based on the first intermediate output word. A decimation filter generates a second intermediate output word by filtering the first intermediate output word. A correction block determines a correction word based on the coarse word, on the first and the second predetermined number of bits and conversion parameters of the incremental ADC. A second combiner generates an output word by addition of the second intermediate output word and the correction word.

Abstract: A wearable ultrasound apparatus is disclosed for use in connection with various biomedical applications, including musculoskeletal (“MSK”) imaging and analysis, In at least one embodiment, the apparatus provides at least one of an ultrasound module configured for obtaining an at least one ultrasound image of a portion of a user’s body on which the at least one ultrasound module is positioned (hereinafter referred to as the “target site” for simplicity purposes), a electrophysiological (“EP”) module configured for detecting bioelectric signals of the target site, and a near-infrared spectroscopy (“NIRS”) module configured for monitoring oxygenation status and/or biochemical measurements of the target site.

Abstract: Compositions and methods for protecting bees from toxins and for preventing or decreasing colony collapse are provided. The compositions comprise carbon microparticles which, when ingested by bees, increase their survival after exposure to toxins such as pesticides.