Patents by Inventor Mao-Hsung Chang

Mao-Hsung Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9186423
    Abstract: A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: November 17, 2015
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.
    Inventors: Wuu-Jyh Lin, Shiou-Shiow Farn, Yean-Hung Tu, Li-Yuan Huang, Dow-Che Chen, Kuo-Yuan Chu, Mao-Hsung Chang, Ting-Shien Duh, Jenn-Tzong Chen, Chyng-Yann Shiue
  • Publication number: 20110077430
    Abstract: The present invention is related to a precursor for no-carrier-added fluorine-18 labeled ethacrynic acid, N-(4-[18F]fluorobutyl)-Ethacrynic amide([18F]FBuEA) and the preparation method for HPLC non-radioactive standards. Its chemical structure is shown in the following: In the precursor, R1 represents a protective group for the amide functional group; R2 represents leaving group; or R1 represents carboxyl group, R2 represents p-tosyloxy, methane sulfonyloxy group or trifluoromethane sulfonyloxy group or bromine (Br). For the HPLC non-radioactive standards, R1 represents a protective group for the amide functional group and hydrogen, R2 represents fluorine.
    Type: Application
    Filed: September 30, 2009
    Publication date: March 31, 2011
    Inventors: Chung-Shan Yu, Li-Wu Chiang, Hao-Lien Huang, Yu-Hsuan Ku, Chia-Jung Chen, Shao Wei Chen, Yean-Hung Tu, Mao-Hsung Chang, Jenn-Tzong Chen, Wuu-Jyn Lin
  • Publication number: 20100243082
    Abstract: A liquid isotope delivery system includes a pressure-controlling unit, an input unit, a target chamber, a proton-radiating unit and a storage unit. The pressure-controlling unit includes a first regulating valve, a second regulating valve connected to the first regulating valve and a third regulating valve connected to the first regulating valve. The input unit is connected to the second regulating valve. The target chamber is connected to the third regulating valve and the input unit. The proton-radiating unit is located near the target chamber. The storage unit is connected to the target chamber.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 30, 2010
    Applicant: ATOMIC ENERGY COUNCIL - INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Wuu-Jyh Lin, Mao-Hsung Chang, Kuo-Yuan Chu, Dow-chi Chen, Ping-Yen Huang, Jenn-Tzong Chen, Ting-shien Duh
  • Patent number: 7678248
    Abstract: A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: March 16, 2010
    Assignee: Atomic Energy Council
    Inventors: Wuu-Jyh Lin, Mao-Hsung Chang, Ping-Yen Huang, Jenn-Tzong Chen, Ting-Shien Duh, Dow-Che Chen, Kuo-Yuan Chu
  • Publication number: 20090211917
    Abstract: A radioisotope Tl-201 is produced. The process includes electroplating, irradiating, dissolving precipitating, ion exchanging, decaying and filtering. The Tl-201 obtained is a liquid having a high purity.
    Type: Application
    Filed: August 9, 2006
    Publication date: August 27, 2009
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Wuu-Jyh Lin, Ting-Shien Duh, Ying-Ming Tsai, Sun-Rong Huang, Chien-Hsin Lu, Mao-Hsung Chang, Jenn-Tzong Chen
  • Patent number: 7578982
    Abstract: A radioisotope TI-201 is produced. The process includes electroplating, irradiating, dissolving, precipitating, ion exchanging, decaying and filtering. The TI-201 obtained is a liquid having a high purity.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: August 25, 2009
    Assignee: Atomic Energy Council- Institute of Nuclear Energy Research
    Inventors: Wuu-Jyh Lin, Ting-Shien Duh, Ying-Ming Tsai, Sun-Rong Huang, Chien-Hsin Lu, Mao-Hsung Chang, Jenn-Tzong Chen
  • Patent number: 7578935
    Abstract: A device to rapidly obtain a solution of Pb(lead)-201 from a solution of a solid target material of Tl(thallium)-203. The solution of Pb-201 is then processed through a degeneration and an ion exchange to obtain in Tl-201 radioisotope.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: August 25, 2009
    Assignee: Atomic Energy Council—Institute of Nuclear Energy Research
    Inventors: Wuu-Jyh Lin, Ting-Shien Duh, Ying-Ming Tsai, Sun-Rong Huang, Chien-Hsin Lu, Mao-Hsung Chang, Jenn-Tzong Chen
  • Publication number: 20080063571
    Abstract: A device to rapidly obtain a solution of Pb(lead)-201 from a solution of a solid target material of Tl(thallium)-203. The solution of Pb-201 is then processed through a degeneration and an ion exchange to obtain in Tl-201 radioisotope.
    Type: Application
    Filed: September 11, 2006
    Publication date: March 13, 2008
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Wuu-Jyh Lin, Ting-Shien Duh, Ying-Ming Tsai, Sun-Rong Huang, Chien-Hsin Lu, Mao-Hsung Chang, Jenn-Tzong Chen
  • Publication number: 20080041719
    Abstract: A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.
    Type: Application
    Filed: August 9, 2006
    Publication date: February 21, 2008
    Applicant: ATOMIC ENERGY COUNCIL-INSTITUTE OF NUCLEAR ENERGY RESEARCH
    Inventors: Wuu-Jyh Lin, Mao-Hsung Chang, Ping-Yen Huang, Jenn-Tzong Chen, Ting-Shien Duh, Dow-Che Chen, Kuo-Yuan Chu