Abstract: Applicant's invention is a stereotactic frame and localization method incorporating localization frames which is operable without the use of head pins or screws. Initially, using the localization frames, natural reference points, lines, and planes are established and aligned in relation to a patient's head. These natural references provide cranial landmarks for proper attachment and alignment of the stereotactic frame. This stereotactic frame includes a means for positioning and locking the frame as well a multiplicity of adjustable elements which are adjusted according to the determined values of the variables such that localization of a target point within a patient's head is possible.