Patents by Inventor María Luisa Toribio

María Luisa Toribio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230151096
    Abstract: The present invention relates to the treatment of T-cell acute lymphoblastic leukemia (T-ALLs) by means of immunotherapy with a monoclonal antibody which recognizes the pre-TCR receptor which, due to its presence in all phases of T-ALL pre-TCR+ development, can also be used as a leukemia-initiating cell (LIC) biomarker and as a therapeutic target useful for monitoring minimal residual disease and identifying compounds inhibiting the disease.
    Type: Application
    Filed: April 16, 2021
    Publication date: May 18, 2023
    Inventors: María Luisa TORIBIO GARCÍA, Balbino ALARCÓN SÁNCHEZ, Juan ALCAIN SÁNCHEZ, Fátima BAYÓN CALDERÓN, Patricia FUENTES VILLAREJO, Marina GARCÍA PEYDRÓ, Sara GONZÁLEZ GARCÍA, Alba MURCIA CEBALLOS
  • Publication number: 20220064311
    Abstract: The present invention provides a novel use and methods comprising antibodies, or antigen-binding fragments thereof, which bind to a CCR7 receptor for use as a novel therapeutic agent in prevention and/or treatment of graft versus host disease (GVHD), preferably in hematopoietic stem cell transplantation (HSCT), more preferably allogeneic hematopoietic stem cell transplantation. GVHD of the invention can be acute (aGVHD) and/or chronic (cGVHD), preferably acute. The antibodies and antigen-binding fragments are capable of selectively depleting ex vivo or in vitro immune cells expressing CCR7 and are capable in vivo of selectively killing immune cells expressing a CCR7 receptor and of impairing/blocking migration and of activation of said immune cells, which are involved in the development and evolution of GVHD.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 3, 2022
    Applicants: Catapult Therapeutics B.V., Universidad Autónoma de Madrid
    Inventors: Carlos Cuesta Mateos, Cecilia Muñoz Calleja, Itxaso Portero Sainz, María del Valle Gómez García de Soria, María Luisa Toribio, Fernando Terrón Fernández