Patents by Inventor Mara Sada

Mara Sada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL CRYSTALLINE COMPOUND OF SIPONIMOD HEMIFUMARATE
    Publication number: 20240150282
    Abstract: The present invention relates to a novel crystalline compound of Siponimod Hemifumarate, to processes and to intermediates for its preparation, to pharmaceutical compositions containing it and to the use in therapy.
    Type: Application
    Filed: July 7, 2021
    Publication date: May 9, 2024
    Applicant: OLON S.P.A.
    Inventors: Matteo VALLI, Alberto MAZZA, Lazzaro FELICIANI, Mara SADA, Giorgio BERTOLINI
  • PROCESS FOR PREPARING HIGH PURITY DEGREE LAROTRECTINIB
    Publication number: 20240059696
    Abstract: A process for preparing Larotrectinib sulfate includes: comprising (a) conducting unblocking reaction of Larotrectinib hydrochloride in a chlorinated hydrocarbon in a presence of a base to obtain Larotrectinib; (b) treating the Larotrectinib with sulfuric acid in methyl ethyl ketone and water to obtain Larotrectinib sulfate; (c) filtering the Larotrectinib sulfate. A content of S-Larotrectinib in the Larotrectinib sulfate is less than 0.10% by weight.
    Type: Application
    Filed: February 18, 2022
    Publication date: February 22, 2024
    Applicant: OLON S.P.A.
    Inventors: Simona TRABACE, Stella DE FIORE, Matteo FUSARI, Jacopo BONANOMI, Barbara NOVO, Mara SADA, Giorgio BERTOLINI
  • PROCESS FOR THE PREPARATION OF A KEY INTERMEDIATE OF SIPONIMOD
    Publication number: 20230322658
    Abstract: The present invention relates to a process for the preparation of a key intermediate and other intermediates useful for the synthesis of Siponimod, a drug used for the treatment of multiple sclerosis. Object of the invention are also said novel intermediates.
    Type: Application
    Filed: July 30, 2021
    Publication date: October 12, 2023
    Applicant: OLON S.P.A.
    Inventors: Matteo VALLI, Mara SADA, Lazzaro FELICIANI, Giorgio BERTOLINI
  • PROCESS FOR THE PREPARATION OF LASMIDITAN AND OF A SYNTHESIS INTERMEDIATE
    Publication number: 20230098051
    Abstract: A process for the preparation of Lasmiditan and of a synthesis intermediate of formula (II): including reacting a compound of Formula (III) wherein X and Y, each independently, represent a halogen atom, with an aqueous solution of ammonia, in presence of at least one bidentate ligand and of at least one copper-based catalyst, and optionally converting the so-obtained compound of Formula (II) into a salt and/or solvate thereof.
    Type: Application
    Filed: December 10, 2020
    Publication date: March 30, 2023
    Inventors: Giuseppe CREMONESI, Christian INVERNIZZI, Mara SADA, Lazzaro FELICIANI, Giorgio BERTOLINI
  • Process for the preparation of lifitegrast
    Patent number: 11498917
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: November 15, 2022
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli
  • STABLE CRYSTALLINE APALUTAMIDE IN PURE FORM, AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20220324831
    Abstract: The present invention relates to a novel non-solvated crystalline form of apalutamide in pure, stable form, and the process for the preparation thereof.
    Type: Application
    Filed: September 7, 2020
    Publication date: October 13, 2022
    Applicant: OLON S.P.A.
    Inventors: Valentina Grande, Alessia Manfredi, Jacopo Bonanomi, Gabriele Ferretti, Barbara Novo, Mara Sada, Giorgio Bertolini
  • SYNTHESIS OF STABLE AMORPHOUS APALUTAMIDE
    Publication number: 20220153718
    Abstract: The present invention relates to a process for the preparation of apalutamide in stable amorphous form. The invention also relates to a novel intermediate crystalline form, called form X, which gives rise to said amorphous form, and a process for obtaining said form X.
    Type: Application
    Filed: March 9, 2020
    Publication date: May 19, 2022
    Applicant: OLON S.P.A.
    Inventors: Valentina Grande, Barbara Novo, Mara SADA, Gabriele Ferretti, Alessia Manfredi
  • Process for the preparation of Crisaborole in a stable crystal form
    Patent number: 11325922
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: May 10, 2022
    Assignee: OLON S.P.A.
    Inventors: Federico Gassa, Lazzaro Feliciani, Alberto Mazza, Marco Quaroni, Mara Sada, Giorgio Bertolini
  • PROCESS FOR THE PREPARATION OF LIFITEGRAST
    Publication number: 20210246123
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Application
    Filed: June 13, 2019
    Publication date: August 12, 2021
    Applicant: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli
  • Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates
    Patent number: 11053227
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: July 6, 2021
    Assignee: OLON S.P.A.
    Inventors: Corrado Colli, Giorgio Bertolini, Mara Sada, Faris Garis, Filippo Nisic, Aldo Bianchi, Cinzia Biaggi, Romano Di Fabio, Silvano Ronzoni, Stefania Bertuolo, Adolfo Prandi, Stefano Maiorana
  • Process for the preparation of a novel umeclidinium synthesis intermediate
    Patent number: 11028082
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 8, 2021
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Filippo Nisic, Mara Sada, Stefania Bertuolo, Silvano Ronzoni, Stefano Maiorana, Romano Di Fabio
  • A PROCESS FOR THE PREPARATION OF CRISABOROLE
    Publication number: 20210070781
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: June 25, 2018
    Publication date: March 11, 2021
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • PROCESS FOR THE SYNTHESIS OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS
    Publication number: 20210061757
    Abstract: Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invention are said novel synthesis intermediates and their use for the preparation of active pharmaceutical ingredients.
    Type: Application
    Filed: April 11, 2019
    Publication date: March 4, 2021
    Inventors: Filippo NISIC, Faris GARIS, Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Romano DI FABIO, Stefano MAIORANA
  • PROCESS FOR THE PREPARATION OF CRISABOROLE IN A STABLE CRYSTAL FORM
    Publication number: 20200407377
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: July 10, 2020
    Publication date: December 31, 2020
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • PROCESS FOR PREPARING INTERMEDIATES FOR THE SYNTHESIS OF OPTICALLY ACTIVE BETA-AMINO ALCOHOLS BY ENZYMATIC REDUCTION AND NOVEL SYNTHESIS INTERMEDIATES
    Publication number: 20200385366
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 10, 2020
    Inventors: Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Faris GARIS, Filippo NISIC, Aldo BIANCHI, Cinzia BIAGGI, Romano DI FABIO, Silvano RONZONI, Stefania BERTUOLO, Adolfo PRANDI, Stefano MAIORANA
  • PROCESS FOR THE PREPARATION OF A NOVEL UMECLIDINIUM SYNTHESIS INTERMEDIATE
    Publication number: 20200102300
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 2, 2020
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Filippo NISIC, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Stefano MAIORANA, Romano DI FABIO
  • Process for preparing intermediates useful in the synthesis of antifungal drugs
    Patent number: 10487070
    Abstract: Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 26, 2019
    Assignee: OLSON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Mara Sada, Federica Colombo
  • PROCESS FOR THE PREPARATION OF CRISABOROLE
    Publication number: 20190194230
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: March 21, 2018
    Publication date: June 27, 2019
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • Process for the preparation of crisaborole
    Patent number: 10329311
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 25, 2019
    Assignee: OLON S.P.A.
    Inventors: Federico Gassa, Lazzaro Feliciani, Alberto Mazza, Marco Quaroni, Mara Sada, Giorgio Bertolini
  • PROCESS FOR PREPARING INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANTIFUNGAL DRUGS
    Publication number: 20190119244
    Abstract: Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 25, 2019
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Mara SADA, Federica COLOMBO