Patents by Inventor Marc E. Parham

Marc E. Parham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5496637
    Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to a process for making a microporous plasmapheresis membrane having an immobilized affinity agent. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: March 5, 1996
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Richard L. Duffy, Donald T. Nicholson
  • Patent number: 5418061
    Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to a microporous plasmapheresis support having an immobilized affinity agent. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous polysulfone support.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: May 23, 1995
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Richard L. Duffy
  • Patent number: 5389463
    Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a halogenated polyolefin polymer and a filler or a halogenated polyolefin polymer and surfactant/filler agent, said sheet product having a fibrous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 50 volume percent composed of pores such that the average pore diameter increases from each major surface towards the interior of the sheet product's thickness.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: February 14, 1995
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Victor S. Chang, Richard T. Giovannoni, Richard C. Hartwig, Joseph T. Lundquist, Christian B. Lundsager, Marc E. Parham, Anthony J. Laccetti
  • Patent number: 5389433
    Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polysulfone polymer and a filler or polysulfone polymer and structure enhancing agent, said sheet product having a fibrous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 60 volume percent composed of pores such that the average pore diameter increases from each major surface toward the interior of the sheet product's thickness.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: February 14, 1995
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Victor S. C. Chang, Richard C. Hartwig, James K. Kung, Joseph T. Lundquist, Marc E. Parham, James A. Avtges, Anthony J. Laccetti
  • Patent number: 5362581
    Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polycarbonate polymer and a filler or a polycarbonate and a structure enhancing agent, said sheet product having a porous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 50 volume percent composed of pores such that the nominal pore diameter increases incrementally from each major surface towards the interior central portion of the sheet product's thickness.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: November 8, 1994
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Victor S. Chang, Richard C. Hartwig, Joseph T. Lundquist, Marc E. Parham, Anthony J. Laccetti
  • Patent number: 5362582
    Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polymer and a filler or a polymer and a structure enhancing agent and having a porous sheet embedded between the first and second major surface. The porosity of the sheet product is at least about 50 volume percent having a pore distribution such that the nominal pore diameter increases from each major surface towards the interior central portion of the sheet product's thickness.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: November 8, 1994
    Assignee: W.R. Grace & Co.-Conn.
    Inventors: Victor S. Chang, Richard C. Hartwig, Joseph T. Lundquist, Marc E. Parham, James K. Kung, James A. Avtges, Anthony J. Laccetti
  • Patent number: 5346788
    Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a thermoplastic polyurethane polymer having a high degree of hard segments with a filler or said polyurethane with a structure enhancing agent, said sheet product having a sheet embedded within said mixture and between the first and second major surfaces. The sheet product has porosity of at least about 50 volume percent composed of pores such that the nominal pore diameter increases from each major surface towards the interior, center of the sheet product's thickness.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: September 13, 1994
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Victor S. C. Chang, Richard C. Hartwig, Joseph T. Lundquist, Marc E. Parham, Anthony J. Laccetti
  • Patent number: 5258149
    Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to a process for making a microporous plasmapheresis membrane having an immobilized affinity agent. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.
    Type: Grant
    Filed: May 5, 1992
    Date of Patent: November 2, 1993
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Richard L. Duffy, Donald T. Nicholson
  • Patent number: 5236644
    Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to the use of an immobilized affinity agent on a microporous plasmapheresis membrane. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: August 17, 1993
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Richard L. Duffy, Donald T. Nicholson
  • Patent number: 5187010
    Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to the use of an immobilized affinity agent on a microporous plasmapheresis membrane. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.
    Type: Grant
    Filed: November 27, 1990
    Date of Patent: February 16, 1993
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Richard L. Duffy
  • Patent number: 4794090
    Abstract: A diagnostic assay support matrix is prepared by coating a support matrix with a polymer resistant to nonspecific protein binding and immobilizing the desired biologically active agent on the polymer surface.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: December 27, 1988
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Marc E. Parham, Julie L. Rudolph
  • Patent number: 4787976
    Abstract: Disclosed is a protein non-adsorptive semipermeable filtration membrane and a process for producing the same. Said membrane, which comprises an interpenetrating polymer network, is prepared from a casting solution comprising a prepolymer polymerizable upon contact with a coagulating liquid, a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, and solvent.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: November 29, 1988
    Assignee: W. R. Grace & Co.
    Inventors: Marc E. Parham, Karen E. Milligan
  • Patent number: 4454347
    Abstract: Crystalline 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane is made by crystallizing the diamino reaction mass from a toluene/heptane solution. The material has been previously purified through a combination of acetic acid washing and treatment with acidic clay. The diamino material, also known as DAPI, is a potential stabilizer, curing agent, and one of the monomers used to produce a polyimide resin.
    Type: Grant
    Filed: February 11, 1983
    Date of Patent: June 12, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Marc E. Parham, Stephen A. Spearman, Gleason O. Cookson