Patents by Inventor Marc E. Parham
Marc E. Parham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5496637Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to a process for making a microporous plasmapheresis membrane having an immobilized affinity agent. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.Type: GrantFiled: April 30, 1993Date of Patent: March 5, 1996Assignee: W. R. Grace & Co.-Conn.Inventors: Marc E. Parham, Richard L. Duffy, Donald T. Nicholson
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Patent number: 5418061Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to a microporous plasmapheresis support having an immobilized affinity agent. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous polysulfone support.Type: GrantFiled: July 21, 1993Date of Patent: May 23, 1995Assignee: W. R. Grace & Co.-Conn.Inventors: Marc E. Parham, Richard L. Duffy
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Patent number: 5389463Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a halogenated polyolefin polymer and a filler or a halogenated polyolefin polymer and surfactant/filler agent, said sheet product having a fibrous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 50 volume percent composed of pores such that the average pore diameter increases from each major surface towards the interior of the sheet product's thickness.Type: GrantFiled: April 1, 1993Date of Patent: February 14, 1995Assignee: W. R. Grace & Co.-Conn.Inventors: Victor S. Chang, Richard T. Giovannoni, Richard C. Hartwig, Joseph T. Lundquist, Christian B. Lundsager, Marc E. Parham, Anthony J. Laccetti
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Patent number: 5389433Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polysulfone polymer and a filler or polysulfone polymer and structure enhancing agent, said sheet product having a fibrous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 60 volume percent composed of pores such that the average pore diameter increases from each major surface toward the interior of the sheet product's thickness.Type: GrantFiled: April 1, 1993Date of Patent: February 14, 1995Assignee: W. R. Grace & Co.-Conn.Inventors: Victor S. C. Chang, Richard C. Hartwig, James K. Kung, Joseph T. Lundquist, Marc E. Parham, James A. Avtges, Anthony J. Laccetti
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Patent number: 5362581Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polycarbonate polymer and a filler or a polycarbonate and a structure enhancing agent, said sheet product having a porous sheet embedded within said mixture and between the first and second major surfaces. The porosity of the sheet product is at least about 50 volume percent composed of pores such that the nominal pore diameter increases incrementally from each major surface towards the interior central portion of the sheet product's thickness.Type: GrantFiled: April 1, 1993Date of Patent: November 8, 1994Assignee: W. R. Grace & Co.-Conn.Inventors: Victor S. Chang, Richard C. Hartwig, Joseph T. Lundquist, Marc E. Parham, Anthony J. Laccetti
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Patent number: 5362582Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a polymer and a filler or a polymer and a structure enhancing agent and having a porous sheet embedded between the first and second major surface. The porosity of the sheet product is at least about 50 volume percent having a pore distribution such that the nominal pore diameter increases from each major surface towards the interior central portion of the sheet product's thickness.Type: GrantFiled: April 1, 1993Date of Patent: November 8, 1994Assignee: W.R. Grace & Co.-Conn.Inventors: Victor S. Chang, Richard C. Hartwig, Joseph T. Lundquist, Marc E. Parham, James K. Kung, James A. Avtges, Anthony J. Laccetti
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Patent number: 5346788Abstract: A battery separator composed of a microporous sheet product having first and second major surfaces and a thickness of less than about 50 mils, formed from a uniform mixture of a thermoplastic polyurethane polymer having a high degree of hard segments with a filler or said polyurethane with a structure enhancing agent, said sheet product having a sheet embedded within said mixture and between the first and second major surfaces. The sheet product has porosity of at least about 50 volume percent composed of pores such that the nominal pore diameter increases from each major surface towards the interior, center of the sheet product's thickness.Type: GrantFiled: April 1, 1993Date of Patent: September 13, 1994Assignee: W. R. Grace & Co.-Conn.Inventors: Victor S. C. Chang, Richard C. Hartwig, Joseph T. Lundquist, Marc E. Parham, Anthony J. Laccetti
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Patent number: 5258149Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to a process for making a microporous plasmapheresis membrane having an immobilized affinity agent. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.Type: GrantFiled: May 5, 1992Date of Patent: November 2, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Marc E. Parham, Richard L. Duffy, Donald T. Nicholson
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Patent number: 5236644Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to the use of an immobilized affinity agent on a microporous plasmapheresis membrane. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.Type: GrantFiled: October 31, 1991Date of Patent: August 17, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Marc E. Parham, Richard L. Duffy, Donald T. Nicholson
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Patent number: 5187010Abstract: The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) from whole blood. More specifically, it relates to the use of an immobilized affinity agent on a microporous plasmapheresis membrane. The immobilized affinity agent is polyacrylic acid bound directly and/or through an interaction with silica and/or calcium chloride to a microporous hollow fiber membrane.Type: GrantFiled: November 27, 1990Date of Patent: February 16, 1993Assignee: W. R. Grace & Co.-Conn.Inventors: Marc E. Parham, Richard L. Duffy
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Patent number: 4794090Abstract: A diagnostic assay support matrix is prepared by coating a support matrix with a polymer resistant to nonspecific protein binding and immobilizing the desired biologically active agent on the polymer surface.Type: GrantFiled: September 26, 1986Date of Patent: December 27, 1988Assignee: W. R. Grace & Co.-Conn.Inventors: Marc E. Parham, Julie L. Rudolph
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Patent number: 4787976Abstract: Disclosed is a protein non-adsorptive semipermeable filtration membrane and a process for producing the same. Said membrane, which comprises an interpenetrating polymer network, is prepared from a casting solution comprising a prepolymer polymerizable upon contact with a coagulating liquid, a polymer that will not react readily with the prepolymer and that is substantially insoluble in said coagulating liquid, and solvent.Type: GrantFiled: April 29, 1985Date of Patent: November 29, 1988Assignee: W. R. Grace & Co.Inventors: Marc E. Parham, Karen E. Milligan
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Patent number: 4454347Abstract: Crystalline 5(6)-amino-1-(4-aminophenyl)-1,3,3-trimethylindane is made by crystallizing the diamino reaction mass from a toluene/heptane solution. The material has been previously purified through a combination of acetic acid washing and treatment with acidic clay. The diamino material, also known as DAPI, is a potential stabilizer, curing agent, and one of the monomers used to produce a polyimide resin.Type: GrantFiled: February 11, 1983Date of Patent: June 12, 1984Assignee: Ciba-Geigy CorporationInventors: Marc E. Parham, Stephen A. Spearman, Gleason O. Cookson