Abstract: The present invention provides methods of treating a S. aureus bloodstream infection (bacteremia) to a patient in need thereof, the method comprising administering ceftobiprole as ceftobiprole miedocaril to the patient at a dosage corresponding to 500 mg of ceffobiprole every 6 hours on days 1 to 8 and 500 mg every 8 hours on days 9 onwards.

Abstract: A process and system for automated online fouling prevention of vertical shell and tube gas-to-gas heat exchangers is provided. The process and system of the invention utilize the flow velocity of the gas within the tubes to facilitate cleaning of the tubes by adding, when necessary, grit to the contaminated gas flow.

Abstract: Accessories of a medical device, such as a defibrillator, are described. The accessories reduce delays in treating or monitoring a patient by increasing the efficiency of using, and the ease of use of, the medical device. An adjustable kickstand is movable between a collapsed and extended position to recline the medical device. In the reclined position, a display of the medical device can be more easily viewed by the user. Storage bags can be coupled to the medical device to efficiently store accessories for use with the medical device. The stored accessories can be coupled to the medical device while the accessories are stored within the storage bags. A port guard can protect and shield a connection between a cable and a port of the medical device to prevent the cable (e.g., an ECG cable) from being disconnected from the port of the medical device.

Abstract: A system performs static program analysis with artifact reuse. The system identifies artifacts associated with the software program being analyzed. The system processes the identified artifacts for performing static program analysis and transmits either the artifacts or identifiers for the artifacts to a second processing device for performing program analysis. The second processing device receives the artifacts and uses the received identifiers to retrieve the artifacts from a networked storage system. The second device also retrieves stored summaries of previous program analysis from the networked storage system. The program analysis uses the retrieved artifacts to generate work units for static program analysis. The analysis is performed only for those work units that are determined to remain unchanged from previous static program analysis cycles.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Systems and methods for matching content elements to surfaces in a spatially organized 3D environment. The method includes receiving content, identifying one or more elements in the content, determining one or more surfaces, matching the one or more elements to the one or more surfaces, and displaying the one or more elements as virtual content onto the one or more surfaces.

Abstract: A spinal interbody device (IBD) includes a solid wall that at least partially defines a boundary of the IBD and a porous body connected to the solid wall. The porous body includes a plurality of sections that form at least a portion of both a superior and inferior bone interface side of the IBD. Each section of the porous body has a different porosity than an adjacent section such that the porosities increase toward a center of the IBD.

Abstract: The present invention provides a method of inducing cell death by hyperactivation of motility networks.

Abstract: The mapping of electric power distribution circuits and electric power outlets to breakers in a breaker panel is accomplished by providing a plurality of smart power testing devices and a control device that communicates with each of the smart power testing devices. Each of the smart power testing devices is connected to a respective one of the electric power outlets in a structure. Each smart power testing device can detect the AC voltage level provided at the electric power outlet. A user opens each breaker in the breaker panel, in succession. When a smart power testing device senses loss of AC voltage, it transmits a message to the control device. The control device can then identify which outlets are on a common electric power circuit, and by opening each breaker in succession, the control device can creating a mapping of outlets to breakers.

Abstract: The disclosed technology is generally directed to blockchain technology. In one example of the technology, a first transaction node of a hosted permissioned blockchain network is provisioned for a first consortium member of the hosted permissioned blockchain network. A shared pool of validator nodes of the hosted permissioned blockchain network is provisioned. The shared pool of validator nodes includes at least one validator node. The shared pool of validator nodes is shared among the plurality of consortium members. The validator nodes of the shared pool of validator nodes are configured for blockchain transaction validation based on a BFT consensus protocol. A second transaction node of the hosted permissioned blockchain network is provisioned for a second consortium member of the hosted permissioned blockchain network. Each transaction node of the hosted permissioned blockchain network is separate from each validator node of the hosted permissioned blockchain network.

Abstract: A rotor blade includes an airfoil having an airfoil shape. The airfoil shape has a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, Table IV, Table V, Table VI, Table VII, Table VIII, or Table IX. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values are joined smoothly with one another to form a complete airfoil shape.

Abstract: The disclosed technology is generally directed to blockchain technology. In one example of the technology, a modified block is provided in response to at least an edit transaction that indicates a transaction in an original block in a blockchain. The modified block includes: transactions of the original block except the indicated transaction, a hash of the indicated transaction, and a header that includes a link to a hash of a block that precedes the original block. A new block is provided. The new block includes a reference associated with the edit transaction, and that the reference may include a link to the modified block. Subscription metadata associated with subscribers to changes in the transaction is retrieved from a stored registry. The subscribers are caused to be notified of the edit transaction.

Abstract: An example method includes receiving, by a digital assistant capable of accessing a plurality of types of health information, a natural language input associated with a type of health information of the plurality of types of health information; in accordance with a determination that the natural language input corresponds to a health domain: determining whether the digital assistant is authorized to access the type of health information; in accordance with a determination that the digital assistant is authorized to access the type of health information: initiating a task based on the natural language input; and in accordance with a determination that the digital assistant is not authorized to access the type of health information: providing a second output indicating that the digital assistant is not authorized to access the type of health information.

Abstract: A rotor blade includes an airfoil having an airfoil shape. The airfoil shape having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, Table IV, Table V, Table VI, Table VII, Table VIII, or Table IX. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values being joined smoothly with one another to form a complete airfoil shape.

Abstract: A fluorescence histo-tomography (FHT) method may include capturing, using an imaging device positioned with respect to a chamber of a slicing apparatus, images of a block face of a specimen retained within the chamber. The images may be captured in the visible and infrared or near-infrared spectrum. The method may include co-registering the images to form a combined image, and providing the combined image to an electronic display. In some implementations, the method may include positioning the imaging device away from the chamber, operating the slicing apparatus to expose a second block face of the specimen, and repositioning the imaging device with respect to the chamber.

Abstract: A stator vane includes an airfoil having an airfoil shape. The airfoil shape has a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in one of Table I, Table II, Table III, Table IV, Table V, Table VI, Table VII, or Table VIII. The Cartesian coordinate values of X, Y and Z are non-dimensional values from 0% to 100% convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values, when connected by smooth continuing arcs, define airfoil profile sections at each Z value. The airfoil profile sections at Z values are joined smoothly with one another to form a complete airfoil shape.

Abstract: A centrifugal pump pet water fountain is provided which includes a bowl defined by a peripheral wall extending upwardly from a floor. The bowl is configured to hold water. The housing divides the basin into a drinking basin and an interior basin. The housing includes an upright sidewall extending from a floor and a cap. The housing also defines an elevated water reservoir with a spout. A rotating cone is positioned within the housing and driven by a motor. The cone has a water inlet and a top opening adjacent the cone top opening. During operation, the rotation of the cone forces water to climb the interior surface of the cone through centrifugal force, where the water is deposited within the reservoir and returned to the drinking basin through the spout.

Abstract: In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes an imaging housing, a fluorescence camera located within the housing, a white light camera located within the imaging housing, and a fluorescence light source located within the imaging housing. The FHT system further includes a support mount configured to support the imaging housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.