Patents by Inventor Marc Emerick
Marc Emerick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10634590Abstract: Apparatus and method for Immunohistochemistry, including a slide holder assembly fixture, a slide holder, a slide holder frame, and a slide holder frame assembly adapted to be placed in communication with a driving force to draw fluid through the slide holder. The slide holder may include an injection port that allows consistent fluid delivery and recovery, while minimizing the introduction of air bubbles. The slide holder may include a reservoir that allows for filling, soaking, rinsing, flushing, uniform antibody coverage of the tissue and reduces handling time, space, and errors, and one or more sample chambers. The slide orientation in the slide holder allows for visualization of label information and tissue to confirm adequate antibody coverage. A multi-port frame allows multiple assays to be carried out concurrently, and is removable from a vacuum manifold and allows for easy transport from the vacuum manifold to an incubator/refrigerator and back.Type: GrantFiled: February 10, 2015Date of Patent: April 28, 2020Assignee: EMD Millipore CorporationInventors: Chris Scott, Paul Sydlowski, John Doyle, Ryan Amara, Libby Kellard, Sara Gutierrez, Marc Emerick
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Patent number: 9783769Abstract: The present invention is a cell cultivating vessel or device, such as a single or multitier flask, including a cover having a top plate, a side wall and a resealable port; an intermediate tray for receiving cells and cell culture media, having a bottom plate, a side wall, and a gap region formed between an interior upwardly angled lip located on an interior portion of the intermediate tray bottom plate and an adjacent outwardly angled side wall portion of the intermediate tray bottom plate, wherein the lip has a outwardly swooping curvilinear edge feature; and a base tray for receiving the cells and cell culture media, including a bottom plate and a side wall.Type: GrantFiled: July 16, 2009Date of Patent: October 10, 2017Assignee: EMD Millipore CorporationInventors: Phillip Clark, Kurt Greenizen, Christopher A. Scott, Marc Emerick
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Publication number: 20160137961Abstract: The present invention is a cell cultivating vessel or device, such as a single or multitier flask, including a cover having a top plate, a side wall and a resealable port; an intermediate tray for receiving cells and cell culture media, having a bottom plate, a side wall, and a gap region formed between an interior upwardly angled lip located on an interior portion of the intermediate tray bottom plate and an adjacent outwardly angled side wall portion of the intermediate tray bottom plate, wherein the lip has a outwardly swooping curvilinear edge feature; and a base tray for receiving the cells and cell culture media, including a bottom plate and a side wall.Type: ApplicationFiled: July 16, 2009Publication date: May 19, 2016Applicant: EMD Millipore CorporationInventors: Phillip Clark, Kurt Greenizen, Christopher A. Scott, Marc Emerick
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Publication number: 20150260621Abstract: Apparatus and method for Immunohistochemistry, including a slide holder assembly fixture, a slide holder, a slide holder frame, and a slide holder frame assembly adapted to be placed in communication with a driving force to draw fluid through the slide holder. The slide holder may include an injection port that allows consistent fluid delivery and recovery, while minimizing the introduction of air bubbles. The slide holder may include a reservoir that allows for filling, soaking, rinsing, flushing, uniform antibody coverage of the tissue and reduces handling time, space, and errors, and one or more sample chambers. The slide orientation in the slide holder allows for visualization of label information and tissue to confirm adequate antibody coverage. A multi-port frame allows multiple assays to be carried out concurrently, and is removable from a vacuum manifold and allows for easy transport from the vacuum manifold to an incubator/refrigerator and back.Type: ApplicationFiled: February 10, 2015Publication date: September 17, 2015Inventors: Chris Scott, Paul Sydlowski, John Doyle, Ryan Amara, Libby Kellard, Sara Gutierrez, Marc Emerick
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Patent number: 8652421Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: October 18, 2006Date of Patent: February 18, 2014Assignee: EMD Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Patent number: 8652422Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: April 1, 2011Date of Patent: February 18, 2014Assignee: EMD Mllipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Publication number: 20140011294Abstract: A rapid, efficient and convenient method to detect one or more biological entities on a blotting membrane is provided. The detection can relate to the position, nature or amount of the biological substance on one or more membranes. The invention method involves a pressure assisted regiment (such as vacuum or positive gas pressure) for the supply and removal of reagents and permits washing of the contaminants from substances embedded in the membrane to be detected using very low volumes of liquid. This method enables completion of the blocking, washing and antibody binding steps in about 30 minutes without comprising blot quality. In another aspect, the invention is directed to an apparatus useful in conducting the method of the invention.Type: ApplicationFiled: September 10, 2013Publication date: January 9, 2014Applicant: EMO Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt E. Greenizen
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Patent number: 8557600Abstract: A rapid, efficient and convenient method to detect one or more biological entities on a blotting membrane is provided. The detection can relate to the position, nature or amount of the biological substance on one or more membranes. The invention method involves a pressure assisted regiment (such as vacuum or positive gas pressure) for the supply and removal of reagents and permits washing of the contaminants from substances embedded in the membrane to be detected using very low volumes of liquid. This method enables completion of the blocking, washing and antibody binding steps in about 30 minutes without comprising blot quality. In another aspect, the invention is directed to an apparatus useful in conducting the method of the invention.Type: GrantFiled: October 18, 2006Date of Patent: October 15, 2013Assignee: EMD Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Patent number: 8460618Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: GrantFiled: October 25, 2010Date of Patent: June 11, 2013Assignee: EMD Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Ykohama, Marc Emerick, Phillip Clark, Kurt Greenizen
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Publication number: 20110256025Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: ApplicationFiled: April 1, 2011Publication date: October 20, 2011Applicant: Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Patent number: 8012434Abstract: An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum. The device also reduces or eliminates overflowing of a well in the event a drain becomes clogged during automated operation.Type: GrantFiled: October 22, 2008Date of Patent: September 6, 2011Assignee: Millipore CorporationInventors: Phillip Clark, Chris A. Scott, Marc Emerick, William Kopaciewicz, Donald B. Rising
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Patent number: 8007745Abstract: An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method of the present invention allow for digestion, desalting and concentration of sample prior to analysis. More specifically, the device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum.Type: GrantFiled: May 24, 2002Date of Patent: August 30, 2011Assignee: Millipore CorporationInventors: Phillip Clark, Chris A. Scott, Marc Emerick, William Kopaciewicz, Donald B. Rising
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Publication number: 20110038757Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips, and other such devices is preferred in doing so.Type: ApplicationFiled: October 25, 2010Publication date: February 17, 2011Applicant: MILLIPORE CORPORATIONInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Publication number: 20090081083Abstract: An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method of the present invention allow for digestion, desalting and concentration of sample prior to analysis. More specifically, the device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum.Type: ApplicationFiled: October 22, 2008Publication date: March 26, 2009Inventors: Phillip Clark, Chris A. Scott, Marc Emerick, William Kopaciewicz, Donald B. Rising
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Publication number: 20070243628Abstract: A rapid, efficient and convenient method to detect one or more biological entities on a blotting membrane is provided. The detection can relate to the position, nature or amount of the biological substance on one or more membranes. The invention method involves a pressure assisted regiment (such as vacuum or positive gas pressure) for the supply and removal of reagents and permits washing of the contaminants from substances embedded in the membrane to be detected using very low volumes of liquid. This method enables completion of the blocking, washing and antibody binding steps in about 30 minutes without comprising blot quality. In another aspect, the invention is directed to an apparatus useful in conducting the method of the invention.Type: ApplicationFiled: October 18, 2006Publication date: October 18, 2007Applicant: Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Publication number: 20070098601Abstract: The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.Type: ApplicationFiled: October 18, 2006Publication date: May 3, 2007Applicant: Millipore CorporationInventors: Masaharu Mabuchi, Hiroko Kimura, Marc Emerick, Phillip Clark, Kurt Greenizen
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Publication number: 20060040395Abstract: An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method of the present invention allow for digestion, desalting and concentration of sample prior to analysis. More specifically, the device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum.Type: ApplicationFiled: August 23, 2005Publication date: February 23, 2006Inventors: Phillip Clark, Chris Scott, Marc Emerick, William Kopaciewicz, Donald Rising
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Publication number: 20050236318Abstract: The present invention provides a device in a multiwell plate that allows for one to obtain substantially all of the liquid that has flowed through the filter thereby reducing hold up volume. This is accomplished by forming at least one hydrophobic area in the hydrophilic filter in each well. After the filtration has occurred, air is allowed to enter the underdrain of the plate through the hydrophobic area(s) which causes any residual fluid held by surface tension to be released and to flow out of the underdrain to the outside environment.Type: ApplicationFiled: February 18, 2005Publication date: October 27, 2005Applicant: Millipore CorporationInventors: Phillip Clark, Marc Emerick, Christopher Scott, Steven Sheridan
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Publication number: 20050236317Abstract: The present invention relates to a multiwell filtration plate system formed of a multiwell filter plate, an underdrain, preferably having spouts as the outlet from the underdrain and a collection device such as a collection plate and the use of a mechanical device such as a fixture in the form of a post, a ramp, a rib, a spout protector ring and the like formed in the collection plate wells or on the outside of the underdrain or both for contacting a forming pendant drop formed on the spout of the underdrain and transferring it to the collection plate well.Type: ApplicationFiled: February 18, 2005Publication date: October 27, 2005Applicant: Millipore CorporationInventors: Kenneth Desilets, Marc Emerick, Christopher Scott, Steven Sheridan
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Publication number: 20050236319Abstract: The present invention is to a filter plate and a collection system having an upper filter plate and a lower collection plate. Each has two or more wells in register with each other. The filter plate has an underdrain containing a spout. The spout is offcenter of the centerpoint of the wells between which it resides. The spout is close to at least one wall of the well of the collection device but set off from that wall by a distance sufficient to ensure easy assembly and disassembly of the devices without contact or damage of the spout with the well of the collection device. In this manner, any drop that begins to form contacts the adjacent well wall and travels down it into the collection device.Type: ApplicationFiled: February 18, 2005Publication date: October 27, 2005Applicant: Millipore CorporationInventors: Marc Emerick, Christopher Scott, Steven Sheridan