Abstract: Featured is a manipulation device the ability to navigate virtual microscopy slides. The device includes an inverted light emitting diode (LED) reflecting light off a textured slide to a complimentary metal oxide semiconductor (CMOS) sensor that indicates the movement of the slide. The slide is freely moved by hand or traditional X-Y-mechanical stage on a raised platform akin to a slide stage. Finger touch controls are provided to zoom to higher or lower power images. The device plugs into a standard computer system by USB port running software to image a virtual microscope slide. Also featured are systems and methods related thereto.