Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: Polymeric blends and thermoplastic compositions which can be used for making thermoplastic workpieces are provided. The polymeric blends and thermoplastic compositions comprise a copolyester and an oxygen scavenging polyester, and optionally an oxidation catalyst. These blends and compositions may be used for making heat-resistant rigid and transparent containers having a low gas permeability. These thermoplastic workpieces and containers may find numerous applications for food, beverage, medical, pharmaceuticals and cosmetic products, as well as for any other application for which it is desirable to inhibit exposure to oxygen during storage. Particular examples provided are bottles and jugs particularly that are useful for hot fill applications.

Abstract: An articulated handle for a container is described. The articulated handle comprises a collar, a grip, and a securing means. The collar is configured for surrounding a container and comprises an articulated joint for positioning the collar between an open state for receiving the container and a close state for surrounding the container. The articulated joint divides the collar in a first portion and a second portion. The grip projects outwardly from the collar and comprises a first grip portion integrally formed to the first portion of the collar and a second grip portion integrally formed to the second portion of the collar. The first and second grip portions are each configured for comprising a complementary portion. The complementary portions comprise a securing means which connects together the first and second grip portions when the collar is in the close state, thereby securing the articulated handle to the container.

Abstract: Polymeric blends and thermoplastic compositions which can be used for making thermoplastic workpieces are provided. The polymeric blends and thermoplastic compositions comprise a copolyester and an oxygen scavenging polyester, and optionally an oxidation catalyst. These blends and compositions may be used for making heat-resistant rigid and transparent containers having a low gas permeability. These thermoplastic workpieces and containers may find numerous applications for food, beverage, medical, pharmaceuticals and cosmetic products, as well as for any other application for which it is desirable to inhibit exposure to oxygen during storage. Particular examples provided are bottles and jugs particularly that are useful for hot fill applications.

Abstract: A drive device for rotating a main mobile assembly relative to a support about a rotation axis includes an intermediate mobile assembly rotated about the same rotation axis. A small travel linear electromagnetic drive device operates tangentially between the intermediate mobile assembly and the mobile assembly, being controlled in accordance with the position of the main mobile assembly relative to the support. A large travel drive device rotates the intermediate mobile assembly relative to the support in accordance with the relative position of the intermediate mobile assembly and the main mobile assembly. End stops delimit predetermined movement of the main mobile assembly relative to the intermediate mobile assembly.

Abstract: An interferometer delay line includes an optical payload displaced along a guide track under the control of a control device including at least one sensing device which senses the position of the payload along the guide track and a drive device acting on the payload. The sensing device includes a linear succession of fixed optical read heads parallel to the guide track and a graduated rule carried by the optical payload in any position on the latter facing at least one of the optical read heads. The sensing device also includes a synchronizing/switching unit causing a counter to count pulses from the heads in succession, the pulses representing distance increments.

Abstract: An electronic circuit for picking-up and shaping signals emitted from the breaker of a conventional or electronic ignition system is provided which consists of an infrared optical coupler in which the emitter is connected to the terminal common to both said breaker and the ignition coil of the ignition system via a circuit capable of calibrating said signals and in which the receiver of said infrared optical coupler is connected to the base of a transistor operating between the locked and the saturated condition wherein the output terminals of said transistor are connected to a circuit capable of eliminating stray signals.

Abstract: A digital computer for calculating the optimal air/fuel mixture of a carburettor-type internal combustion engine by injecting a variable amount of air into the main air induction system, comprising an address computer disposed between the contract breaker and the memories of the computer; a first memory containing the data concerning the characteristics of the engine, said data being stored as a function of the rotational velocity of the engine; a second memory containing the data concerning the subservience velocity as a function of the engine rotational velocity; and an injection time computer adapted to sum up the data received by said first memory and the data received by an up-and-down-counter responsive both to a chemical analysis probe and to the second memory, said injection time computer being connected to a circuit for triggering said solenoid operated valve.