Abstract: A method and a system for noise discrimination, the method comprising measuring noise levels of a noise source, measuring noise levels at a target location positioned at a distance from the noise source, measuring wind speed and direction in an area comprising the noise source and the target location, filtering transient short-duration events from the noise levels measured at the noise source, yielding filtered noise levels of the noise source, filtering transient short-duration events from the noise levels measured at the target location, yielding filtered noise levels of the target location, measuring a sound transfer function between the noise source and the target location using the filtered noise levels, comparing the measured sound transfer function with a reference transfer function; and when the difference between the measured transfer function and the reference transfer function is above a predetermined threshold, determining a probability that noise at the location originates from the noise source.

Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2?-(S)-fluoro-thio-adenosine monophosphate or 2?-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: Various embodiments of electronic flares are described which generally comprise a light module that is disposed along a portion of a housing and includes at least one light source for emitting light according to a lighting mode, a power source for providing power to the light module, a circuit board that is disposed within the housing and is electrically coupled to the power source and light module, the circuit board including a controller for providing power to the light module according to the selected lighting mode when the electronic flare is activated; and a switch having an external switch portion and an internal switch portion coupled to one another, the external switch portion being disposed along an outer portion of the housing and the internal switch portion being operatively coupled to the circuit board, the external switch portion being rotatably movable by a user to one or more positions where each position is associated with a different lighting mode allowing the user to select the lighting mode

Abstract: Various embodiments of electronic flares are described which generally comprise a light module that is disposed along a portion of a housing and includes at least one light source for emitting light according to a lighting mode, a power source for providing power to the light module, a circuit board that is disposed within the housing and is electrically coupled to the power source and light module, the circuit board including a controller for providing power to the light module according to the selected lighting mode when the electronic flare is activated; and a switch having an external switch portion and an internal switch portion coupled to one another, the external switch portion being disposed along an outer portion of the housing and the internal switch portion being operatively coupled to the circuit board, the external switch portion being rotatably movable by a user to one or more positions where each position is associated with a different lighting mode allowing the user to select the lighting mode

Abstract: A method and a system for noise discrimination, the method comprising measuring noise levels of a noise source, measuring noise levels at a target location positioned at a distance from the noise source, measuring wind speed and direction in an area comprising the noise source and the target location, filtering transient short-duration events from the noise levels measured at the noise source, yielding filtered noise levels of the noise source, filtering transient short-duration events from the noise levels measured at the target location, yielding filtered noise levels of the target location, measuring a sound transfer function between the noise source and the target location using the filtered noise levels, comparing the measured sound transfer function with a reference transfer function; and when the difference between the measured transfer function and the reference transfer function is above a predetermined threshold, determining a probability that noise at the location originates from the noise source.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The disclosure is directed at a method and system for improving situational awareness and accuracy of a user with a firearm. The system includes a blank firing laser attachment which is mounted to an end of the firearm and emits a laser when the trigger is pulled.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The system of the present invention is used to execute data consolidation to combine data from Google, MSN and Yahoo, at least. The user does not need anymore to combine by himself data in spreadsheets. The system allows creating consolidated campaigns that span across search providers, letting the user effortlessly build reports that previously took hours to create each month. The system of the present invention is particularly suited for agencies. A tool designed for agencies needs to allow for management at the client level as well as the agency level. The system client center gives each member of the team a summary view of the client accounts that they're responsible for, along with emerging trend indicators for every major metric.

Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.