Patents by Inventor Marc Ramer
Marc Ramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11389566Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: GrantFiled: March 14, 2017Date of Patent: July 19, 2022Assignees: Regentys Corporation, University of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20210093751Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration extracellular matrix hydrogel (ECMH) which stimulates stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: July 7, 2020Publication date: April 1, 2021Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20190076574Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: March 14, 2017Publication date: March 14, 2019Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20170112964Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: November 3, 2016Publication date: April 27, 2017Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20160045552Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: April 8, 2014Publication date: February 18, 2016Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20110166425Abstract: A surgical apparatus for introduction of laparoscopic instruments into an anatomical cavity through tissue at an entry site. The apparatus includes a body with a frustoconical-shaped wall. The body defines an interior cavity, an open bottom, and a substantially closed top wall with openings from which a plurality of ports extend upward therefrom. The ports are adapted to receive the laparoscopic instruments for introduction through the interior cavity and open bottom of the body into the anatomical cavity. In the preferred embodiment, the frustoconical-shaped wall of the body is placed through an incision in the umbilicus. In one aspect of the invention, the body is a unitary one-piece molded structure. A reinforcing belt or plate formed from a relatively hard material can be integral to the body, and separately formed port caps each having a septum may be bonded to the ports.Type: ApplicationFiled: September 4, 2009Publication date: July 7, 2011Inventors: David S. Edelman, Leonard Pinchuk, John B. Martin, JR., Bryan M. Pinchuk, Marc Ramer
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Patent number: 7500988Abstract: A stent-graft for insertion into a body lumen, such as a blood vessel, is utilized in order to repair such lumen. The stent-graft includes a substantially cylindrical hollow expandable stent comprising a plurality of interconnected struts. The stent has a distal end and a proximal end, and an interior surface and an exterior surface. At least one strut of the stent has first and second apertures extending therethrough from the interior surface to the exterior surface. The stent-graft also includes a graft member covering a predetermined portion of least one of the interior surface and the exterior surface of the stent. In addition, the stent-graft further includes a staple for attaching the graft member to the stent. The staple has a crown and two legs extending therefrom. At least one of the legs of the staple extends through the graft material and through the first aperture. Both of the legs are bent inwardly towards said crown such that they evert back and extend through the second aperture.Type: GrantFiled: November 16, 2000Date of Patent: March 10, 2009Assignee: Cordis CorporationInventors: Frank Butaric, Bill K. Ng, Marc Ramer, Dieter Stoeckel, Gregory Mast, Luis A. Davila, Kenneth S. Solovay
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Publication number: 20080132991Abstract: A method for producing ionically cross-linked gellan gum includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca2+), or possibly strontium (Sr2+), magnesium (Mg2+), barium (Ba2+), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.Type: ApplicationFiled: November 30, 2006Publication date: June 5, 2008Inventors: Leonard Pinchuk, Yasushi Pedro Kato, Marc Ramer
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Patent number: 7314483Abstract: The present invention is directed to a system, apparatus, and method for treating, repairing, and/or replacing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a first prosthesis or stent gasket, and at least one second prosthesis for bypassing the aneurysm. In preferred embodiments, the second prosthesis includes a branch leg that may be disposed and anchored in an either a cross artery or a downstream artery to facilitate fluid flow. In other preferred embodiments, at least one third prosthesis is provided for establishing a fluid flow channel through a second diseased artery to bypass an aneurysm disposed therein. In accordance with the invention, the first artery may be the abdominal aorta and the second artery may be an iliac artery.Type: GrantFiled: January 8, 2002Date of Patent: January 1, 2008Assignee: Cordis Corp.Inventors: George D. Landau, Marc Ramer, Kenneth S. Solovay
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Patent number: 7267685Abstract: The invention is a system, apparatus, and method for treating, and/or repairing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a prosthesis assembly for establishing a fluid flow path between an upstream portion of an artery and at least one bifurcated downstream portion of the artery.Type: GrantFiled: January 8, 2002Date of Patent: September 11, 2007Assignee: Cordis CorporationInventors: Frank Butaric, William L. Howat, Robert P. Letendre, Marc Ramer, Kenneth S. Solovay
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Patent number: 7232461Abstract: An aneurysm neck covering device which is particularly useful for sealing the neck of an aneurysm located in the vicinity of a bifurcated blood vessel. The neck covering device includes a self-expanding stent for supporting and retaining a self-expanding neck cover which seals the neck of the aneurysm.Type: GrantFiled: October 29, 2003Date of Patent: June 19, 2007Assignee: Cordis Neurovascular, Inc.Inventor: Marc Ramer
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Publication number: 20070067015Abstract: An expandable stent having a covering which exhibits the characteristic of being normally dissolvable in blood, but upon being activated, becomes inert to blood. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter the portion of the covering of the stent across the neck of the aneurysm is activated to become inert to blood and the balance of the covering dissolves to permit blood to flow to adjacent vessels.Type: ApplicationFiled: November 21, 2006Publication date: March 22, 2007Inventors: Donald Jones, Marc Ramer
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Patent number: 7156871Abstract: An expandable stent having a covering which exhibits the characteristic of being normally dissolvable in blood, but upon being activated, becomes inert to blood. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter the portion of the covering of the stent across the neck of the aneurysm is activated to become inert to blood and the balance of the covering dissolves to permit blood to flow to adjacent vessels.Type: GrantFiled: October 28, 2004Date of Patent: January 2, 2007Assignee: Cordis Neurovascular, Inc.Inventors: Donald K. Jones, Marc Ramer
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Publication number: 20060095111Abstract: An expandable stent having a covering which exhibits the characteristic of being normally dissolvable in blood, but upon being activated, becomes inert to blood. The stent may be placed across the neck of an aneurysm to seal the aneurysm and thereafter the portion of the covering of the stent across the neck of the aneurysm is activated to become inert to blood and the balance of the covering dissolves to permit blood to flow to adjacent vessels.Type: ApplicationFiled: October 28, 2004Publication date: May 4, 2006Inventors: Donald Jones, Marc Ramer
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Publication number: 20050096728Abstract: An aneurysm neck covering device which is particularly useful for sealing the neck of an aneurysm located in the vicinity of a bifurcated blood vessel. The neck covering device includes a self-expanding stent for supporting and retaining a self-expanding neck cover which seals the neck of the aneurysm.Type: ApplicationFiled: October 29, 2003Publication date: May 5, 2005Inventor: Marc Ramer
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Patent number: 6887268Abstract: An endoluminal aneurysm treatment system of an expandable bypass prosthesis and an extension prosthesis with a flared distal portion which, upon expansion, frictionally engages the proximal end of the bypass prosthesis.Type: GrantFiled: January 8, 2002Date of Patent: May 3, 2005Assignee: Cordis CorporationInventors: Frank Butaric, William L. Howat, Marc Ramer, Kenneth S Solovay
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Patent number: 6656215Abstract: A stent-graft for insertion into a body lumen, such as a blood vessel, is utilized in order to repair such lumen. The stent-graft includes a substantially cylindrical hollow expandable stent comprising a plurality of interconnected struts. The stent has a distal end and a proximal end, and an interior surface and an exterior surface. At least one strut of the stent has first and second apertures extending therethrough from the interior surface to the exterior surface. The stent-graft also includes a graft member covering a predetermined portion of least one of the interior surface and the exterior surface of the stent. In addition, the stent-graft further includes a staple for attaching the graft member to the stent. The staple has a crown and two legs extending therefrom. At least one of the legs of the staple extends through the graft material and through the first aperture. Both of the legs are bent inwardly towards said crown such that they evert back and extend through the second aperture.Type: GrantFiled: November 16, 2000Date of Patent: December 2, 2003Assignee: Cordis CorporationInventors: Andrew Yanez, Frank Butaric, Marc Ramer
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Publication number: 20020058987Abstract: The invention is a system, apparatus, and method for treating, and/or repairing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a prosthesis assembly for establishing a fluid flow path between an upstream portion of an artery and at least one bifurcated downstream portion of the artery.Type: ApplicationFiled: January 8, 2002Publication date: May 16, 2002Inventors: Frank Butaric, William L. Howat, Robert P. Letendre, Marc Ramer, Kenneth S. Solovay
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Publication number: 20020058984Abstract: The invention is a system, apparatus, and method for treating, repairing, and/or replacing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a first prosthesis or stent gasket, at least one second prosthesis for bypassing the aneurysm, and a third or extension prosthesis.Type: ApplicationFiled: January 8, 2002Publication date: May 16, 2002Inventors: Frank Butaric, William L. Howat, Marc Ramer, Kenneth S. Solovay
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Publication number: 20020058986Abstract: The present invention is directed to a system, apparatus, and method for treating, repairing, and/or replacing an aneurysm, preferably an aortic aneurysm, and most preferably, an abdominal aortic aneurysm. The systems, devices, and methods of the present invention include a first prosthesis or stent gasket, and at least one second prosthesis for bypassing the aneurysm. In preferred embodiments, the second prosthesis includes a branch leg that may be disposed and anchored in an either a cross artery or a downstream artery to facilitate fluid flow. In other preferred embodiments, at least one third prosthesis is provided for establishing a fluid flow channel through a second diseased artery to bypass an aneurysm disposed therein. In accordance with the invention, the first artery may be the abdominal aorta and the second artery may be an iliac artery.Type: ApplicationFiled: January 8, 2002Publication date: May 16, 2002Inventors: George D. Landau, Marc Ramer, Kenneth S. Solovay