Abstract: A fan blade (1) has a front inflow edge (2) and a rear outflow edge (3). The fan blade (1) has an at least partially wavy inflow edge (4) that forms a wave (W) having a specific three-dimensional waveform.

Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: A fan blade (1) has a front inflow edge (2) and a rear outflow edge (3). The fan blade (1) also has an at least partially wavy inflow edge (4), that forms a wave (W) having a specific three-dimensional waveform.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: A method and system for determining a path of data traffic based on a destination Internet Protocol (IP) address, the destination IP address being either private or public and belonging to any one of multiple organizations. In the method and system, a VPN is activated at a telecommunication endpoint. In response to activating the VPN, a service device on a private network interconnects with a VPN gateway. A subscriber identifier associated with the telecommunication endpoint and the destination IP address of one of the multiple organizations is received at a managed service platform. If both the subscriber identifier and the destination IP address of the one of the multiple organizations are not registered in a predetermined policy database at the telecommunication endpoint, a subscriber identified by the subscriber identifier is prompted to register the subscriber identifier associated with the telecommunication endpoint.

Abstract: A fan blade (1) has a front leading edge (2) and a rear trailing edge (3). The fan blade (1) has a leading edge (4), at least some portions, that are undulated. The edge forms a wave (W) with a specific three-dimensional waveform.

Abstract: A fan blade (1) has a front inflow edge (2) and a rear outflow edge (3). The fan blade (1) has an at least partially wavy inflow edge (4) that forms a wave (W) having a specific three-dimensional waveform.

Abstract: A fan blade (1) has a front inflow edge (2) and a rear outflow edge (3). The fan blade (1) has an at least partially wavy inflow edge (4). The wavy inflow edge (4) forms a wave (W) with a specific three-dimensional waveform.

Abstract: A system for determining the position of a movable object in space includes a marker which is to be applied to the object. The marker has a surface which is subdivided into a plurality of individual fields. The fields each have a statistical noise pattern. The system also includes an image capture unit which is remote from the object and is arranged to capture an image of the marker. The system further includes an image evaluation unit which stores a reference image of the noise patterns and is designed to locate at least one of the fields in the currently captured image of the marker by comparison with the reference image in order to determine a current position of the marker in space. There are corresponding methods for determining a position the object.

Abstract: The present invention relates to an active substance delivery system, preferably an anti-cancer agent delivery system, comprising one or more active substances included in nanoparticles and a method for producing such a delivery system.

Abstract: An axial fan for use with a wall ring plate includes a housing having an inlet region and a rotor. The rotor has an increased rotor diameter compared to a standardised rotor diameter. On the inlet side, the inlet region has a tapered section that narrows in an arched manner in a cross-sectional view from an inlet diameter to a wall ring diameter. The axial width and radial length of the tapered section are formed in a predetermined ratio.

Abstract: A method and system for determining a path of data traffic based on a destination Internet Protocol (IP) address, the destination IP address being either private or public and belonging to any one of multiple organizations. In the method and system, a VPN is activated at a telecommunication endpoint. In response to activating the VPN, a service device on a private network interconnects with a VPN gateway. A subscriber identifier associated with the telecommunication endpoint and the destination IP address of one of the multiple organizations is received at a managed service platform. If both the subscriber identifier and the destination IP address of the one of the multiple organizations are not registered in a predetermined policy database at the telecommunication endpoint, a subscriber identified by the subscriber identifier is prompted to register the subscriber identifier associated with the telecommunication endpoint.

Abstract: An urinary pumping device for generating a fluid flow through a urethra of a patient includes an activation arrangement configured to induce intermittent compression and release of the urethra, and a mounting structure to mount and unmount the activation arrangement to a body of the patient. The mounting structure is configured to position the activation arrangement on the body of the patient such that the urethra of the patient can be intermittently compressed and released by the activation arrangement.

Abstract: A urinary pumping device (1) for generating a fluid flow through an urethra (22; 220) of a patient (2; 20), comprises an implantable activation arrangement (11) and a control unit (12). The implantable activation arrangement (11) is configured to induce intermittent compression and release of the urethra (22) when being implanted into the patient (2). The control unit (12) is coupled to the activation arrangement (11). The control unit (12) is configured to operate the activation arrangement (11) such that the fluid flow through the urethra (22) is generated by the activation arrangement (11) inducing intermittent compression and release of the urethra (22).

Abstract: A method and system for determining a path of data traffic based on a destination Internet Protocol (IP) address, the destination IP address being either private or public and belonging to any one of multiple organizations. In the method and system, a VPN is activated at a telecommunication endpoint. In response to activating the VPN, a service device on a private network interconnects with a VPN gateway. A subscriber identifier associated with the telecommunication endpoint and the destination IP address of one of the multiple organizations is received at a managed service platform. If both the subscriber identifier and the destination IP address of the one of the multiple organizations are not registered in a predetermined policy database at the telecommunication endpoint, a subscriber identified by the subscriber identifier is prompted to register the subscriber identifier associated with the telecommunication endpoint.

Abstract: The invention relates to a method for the diagnosis or prognosis of a cancer comprising (i) determining a level of expression of Myb-related transcription factor (MYPOP) or a part thereof in a patient sample; (ii) comparing the level of MYPOP expression of the patient sample to levels of a normal sample; (iii) correlating the level of MYPOP expression in the patient sample relative to the levels in the normal sample with a positive or negative diagnosis or prognosis of cancer.

Abstract: A method and a system for determining a path of data traffic based on a destination Internet Protocol (IP) address, the destination IP address being either private or public and belonging to any one of multiple organizations. In the method and system, a subscribed device identifier and the destination IP address of one of the multiple organizations is received at a managed service platform. If both the subscribed device identifier and the destination IP address of the one of the multiple organizations are not registered in a predetermined policy database, a subscriber or an owner of the subscribed device is prompted, at a telecommunications endpoint associated with the subscribed device identifier, to register the endpoint. The subscribed device identifier is then registered in the predetermined policy database, based on information received from the telecommunications endpoint in response to the prompting.

Abstract: A method and a system for determining a path of data traffic based on a destination Internet Protocol (IP) address, the destination IP address being either private or public and belonging to any one of multiple organizations. In the method and system, a subscribed device identifier and the destination IP address of one of the multiple organizations is received at a managed service platform. If both the subscribed device identifier and the destination IP address of the one of the multiple organizations are not registered in a predetermined policy database, a subscriber or an owner of the subscribed device is prompted, at a telecommunications endpoint associated with the subscribed device identifier, to register the endpoint. The subscribed device identifier is then registered in the predetermined policy database, based on information received from the telecommunications endpoint in response to the prompting.