Patents by Inventor Marc Vendrell Escobar

Marc Vendrell Escobar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular probes for detecting gram-negative bacteria in vitro and in vivo
    Patent number: 10648979
    Abstract: A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: May 12, 2020
    Assignee: The University Court of the University of Edinburgh
    Inventors: Mark Bradley, Annamaria Helena Lilienkampf, Nikolaos Avlonitis, Marc Vendrell Escobar, Neil Alexander McDonald, Christopher Haslett, Kanwaldeep Dhaliwal, Timothy Simon Walsh
  • Fluorescent polybranched probes for detecting bacteria and/or fungi in vitro and in vivo
    Patent number: 10520504
    Abstract: A probe for detecting bacteria and/or fungi in vitro and in vivo is provided, the probe having a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and having a fluorophore and a binding moiety, wherein the binding moiety is a bacteria binding moiety and selectively binds to bacteria and/or to fungi and not to animal cells. Methods of use of the probe and kits comprising the probe are also provided.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: December 31, 2019
    Assignee: The University Court of the University of Edinburgh
    Inventors: Mark Bradley, Annamaria Helena Lilienkampf, Nikolaos Avlonitis, Marc Vendrell Escobar, Neil Alexander McDonald, Christopher Haslett, Kanwaldeep Dhaliwal, Timothy Simon Walsh
  • MOLECULAR PROBES FOR DETECTING GRAM-NEGATIVE BACTERIA IN VITRO AND IN VIVO
    Publication number: 20180231548
    Abstract: A probe is provided comprising a label and a binding moiety, Deliver First Probe wherein the binding moiety is adapted to bind to gram-negative bacteria, and to Target Area to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.
    Type: Application
    Filed: November 13, 2015
    Publication date: August 16, 2018
    Inventors: Mark BRADLEY, Annamaria Helena LILIENKAMPF, Nikolaos AVLONITIS, Marc Vendrell ESCOBAR, Neil Alexander MCDONALD, Christopher HASLETT, Kanwaldeep DHALIWAL, Timothy Simon WALSH
  • FLUORESCENT POLYBRANCHED PROBES FOR DETECTING BACTERIA AND/OR FUNGI IN VITRO AND IN VIVO
    Publication number: 20180120314
    Abstract: A probe is provided comprising a core and a plurality of probe elements; each probe element within the plurality of probe elements extending from the core and comprising a fluorophore and a binding moiety. Methods of use of the probe and kits comprising the probe are also provided.
    Type: Application
    Filed: November 13, 2015
    Publication date: May 3, 2018
    Inventors: Mark BRADLEY, Annamaria Helena LILIENKAMPF, Nikolaos AVLONITIS, Marc Vendrell ESCOBAR, Neil Alexander MCDONALD, Christopher HASLETT, Kanwaldeep DHALIWAL, Timothy Simon WALSH
  • Megastokes amino-triazolyl-BODIPY compounds and applications to live neuron staining and human serum albumin FA1 drug site probing
    Patent number: 9513294
    Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: December 6, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Jun Cheng Er, Cheryl Kit Mun Leong, Seong Wook Yun, Marc Vendrell Escobar, Mui Kee Tang
  • Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells
    Patent number: 9267949
    Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: February 23, 2016
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Marc Vendrell Escobar, Duanting Zhai, Nam-Young Kang, Yogeswari Chandran
  • Development of photostable near-IR cyanine dyes for in vivo imaging
    Patent number: 9201014
    Abstract: A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: December 1, 2015
    Assignees: National University of Singapore, Agency for Science, Technology and Research
    Inventors: Young-Tae Chang, Animesh Samanta, Marc Vendrell Escobar, Nam-Young Kang, Kaustabh Kumar Maiti, Kiat Seng Soh, Dinish Unnimadhava Kurup Soudamini Amma, Malini Olivo, Sung-Jin Park, Raj Kumar Das
  • Megastokes Amino-Triazolyl-Bodipy Compounds And Applications To Live Neuron Staining And Human Serum Albumin FA1 Drug Site Probing
    Publication number: 20150309040
    Abstract: A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes Human Serum Albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.
    Type: Application
    Filed: December 26, 2013
    Publication date: October 29, 2015
    Inventors: Young-Tae Chang, Jun Cheng Er, Cheryl Kit Mun Leong, Seong Wook Yun, Marc Vendrell Escobar, Mui Kee Tang
  • Alkylamino BODIPY Dyes As Selective Fluorescent Probes For Proteins And Mouse Embryonic Stem Cells
    Publication number: 20140121129
    Abstract: The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.
    Type: Application
    Filed: June 15, 2012
    Publication date: May 1, 2014
    Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Young-Tae Chang, Marc Vendrell Escobar, Duanting Zhai, Nam-Young Kang, Yogeswari Chandran
  • PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS
    Publication number: 20110160185
    Abstract: Pyrrolopyrimidine derivatives of Formula (I) that are useful as JAK3 kinase inhibitors.
    Type: Application
    Filed: March 31, 2008
    Publication date: June 30, 2011
    Inventors: Jorge Salas Solana, Carmen Almansa Rosales, Robert Soliva Soliva, Montserrat Fontes Ustrell, Marc Vendrell Escobar
  • PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS
    Publication number: 20100113420
    Abstract: Pyrrolopyrimidine derivatives of Formula (I) that are useful as JAK3 kinase inhibitors.
    Type: Application
    Filed: March 31, 2008
    Publication date: May 6, 2010
    Inventors: Jorge Salas Solana, Carmen Almansa Rosales, Robert Soliva Soliva, Montserrat Fontes Ustrell, Marc Vendrell Escobar