Abstract: The invention relates to an airfoil for a gas turbine, which comprises a compound fillet disposed between the airfoil and a platform. The compound fillet consists of a first arc and a second arc. A first end of the first arc tangentially adjoins an outer surface of the airfoil. A second end of the first arc tangentially adjoins a first end of the second arc. A second end of the second arc tangentially adjoins a surface of the platform, wherein the following equation is satisfied: 0.15?R1/s?0.45, and 0.09?a/s?0.27.

Abstract: The invention relates to a method for closing an aperture on a blade of a gas turbine, wherein the blade of the gas turbine comprises a tip end with a top surface and a bottom surface. The aperture is formed on the tip end of the blade, and the aperture includes a peripheral edge. The method includes closing the aperture with a weld formed by means of a Tungsten Inert Gas(TIG) welding process without an insert placed in the aperture. With the technical solution of the present invention, it provides a simple and cost effective solution to close the aperture on the tip end of the blade, dispensing with the conventionally utilized “letter-box”, insert, tip cap and the like. In view of this, process of closing the aperture may be simplified, and the cost incurred may be reduced. Further, premature failure of the blade is prevented.

Abstract: The present invention relates to a blade of turbine having an aerofoil, a platform and a root portion configured to be slidingly received in mounting slots of a rotor disc. The blade further includes a locking member disposed on the root portion and engaged with the rotor disc to make axial fixation of the blade to the rotor disc. With the technical solution of the present invention, it provides a blade with simple and cost effective axial locking system to make axial fixation of the blade relative to the rotor disc, and also a fail-safe solution during assembly process.

Abstract: The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as ROR?, ROR?, or ROR?. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.

Abstract: The guide vane of a gas turbine comprises a blade having an outer platform connectable to a guide vane carrier or gas turbine casing, and at the opposite end an inner platform that carries a cover plate. The inner platform has a dovetail housing to which the cover plate is connected. The method for replacing the cover plate consists in separating the cover plate from the inner platform by cutting along the profile of the dovetail housing, then making the cover plate to slide out of the dovetail housing, thus inserting a new or refurbished cover plate into the dovetail housing.

Abstract: A hollow-cast casting is provided, which includes at least one core opening that is caused by the production technique and which has a closure device that closes the core opening. The closure device can be inserted into the core opening axially in relation to the core opening and provides at least one surface region which, in axial projection in relation to the core opening, can be made to abut a surface region of the casting that is facing toward the casting. The surface region lies radially outside a cross-sectional area predetermined by the core opening.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: The invention provides molecular entities that bind with high affinity to PPARG (PPAR?), and inhibit kinase-mediated (e.g., cdk5-mediated) phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes, insulin resistance, impaired glucose tolerance, pre-diabetes, hyperglycemia, hyperinsulinemia, obesity, or inflammation. Side effects such as significant weight gain, edema, impairment of bone growth or formation, or cardiac hypertrophy, or any combination thereof, can be avoided in the mammal receiving the compound. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.

Abstract: The invention provides molecular entities that bind with high affinity to PPARG (PPAR?), inhibit kinase-mediated, e.g., cdk5-mediated, phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes, insulin resistance, impaired glucose tolerance, pre-diabetes, hyperglycemia, hyperinsulinemia, obesity, or inflammation. In methods of treatment of these conditions using a compound of the invention, the compound can avoid producing side effects of significant weight gain, edema, impairment of bone growth or formation, or cardiac hypertrophy, or any combination thereof, in the patient receiving the compound. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.

Abstract: A hollow-cast casting is provided, which includes at least one core opening that is caused by the production technique and which has a closure device that closes the core opening. The closure device can be inserted into the core opening axially in relation to the core opening and provides at least one surface region which, in axial projection in relation to the core opening, can be made to abut a surface region of the casting that is facing toward the casting. The surface region lies radially outside a cross-sectional area predetermined by the core opening.

Abstract: The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.

Abstract: The guide vane of a gas turbine comprises a blade having an outer platform connectable to a guide vane carrier or gas turbine casing, and at the opposite end an inner platform that carries a cover plate. The inner platform has a dovetail housing to which the cover plate is connected. The method for replacing the cover plate consists in separating the cover plate from the inner platform by cutting along the profile of the dovetail housing, then making the cover plate to slide out of the dovetail housing, thus inserting a new or refurbished cover plate into the dovetail housing.

Abstract: A gas turbine includes a supporting structure which concentrically surrounds a hot gas path and is shielded with respect to the hot gas path by an annular heat shield (15?), which heat shield (15?) includes a multiplicity of segments which are arranged one behind the other in a circumferential direction and which in each case butt against one another in the circumferential direction so as to form a gap, seals (16?), being arranged for sealing off the gaps between the segments butting against one another, the seals having thin elongate sealing strips (23), which are accommodated in corresponding sealing slots (19), delimited transversely with respect to the longitudinal direction by a wall (25), in the mutually opposite end faces of the segments of the heat shield (15?) which butt against one another.

Abstract: For preparing a gas stream cleaned from dust and dirt particles, a device is proposed in which an outflow channel (2) for cleaned medium has at its mouth in an inflow channel (1) an extension element (4), which projects into the inflow channel. A cover element (6) covers an end inflow aperture (4a) of the extension element. In an embodiment of the invention, the extension element (4) has lateral inlet apertures (5). The cover element (6) is preferably constituted hood-shaped, and has axial extension elements (6a), which at least partially cover the extension element (4) in the axial direction, and advantageously extend over the lateral inlet apertures. The stream entering the outflow channel (2) for cleaned medium must overcome strong flow deflections, so that particles with a low flow following ability cannot get into this channel. Further outflow channels (3) for conducting the remaining dust-laden medium are arranged substantially flush with the wall (7) of the inflow channel.

Abstract: The present invention relates to compounds of the Formula (I), and their pharmaceutically acceptable salts.

Abstract: The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract: The present invention relates to compounds of the Formulae (I) and (II), wherein R1-R10 and G are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

Abstract: The present invention relates to compounds of the formulae (I)-(XII), wherein R1-R71, A, B, X, Y, G, L and Z are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.