Patents by Inventor Marcel Leo de Vocht

Marcel Leo de Vocht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the purification of poliovirus from cell cultures
    Patent number: 10294460
    Abstract: The disclosure provides methods for poliovirus purification from crude cell culture harvests using a detergent followed by a clarification step.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: May 21, 2019
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Mariken Segers, Beckley Kungah Nfor, Feras Nachmi Alazi, Marcel Leo De Vocht
  • PROCESS FOR THE PURIFICATION OF POLIOVIRUS FROM CELL CULTURES
    Publication number: 20170166872
    Abstract: The disclosure provides methods for poliovirus purification from crude cell culture harvests using a detergent followed by a clarification step.
    Type: Application
    Filed: July 21, 2015
    Publication date: June 15, 2017
    Applicant: Janssen Vaccines & Prevention B.V.
    Inventors: Mariken Segers, Beckley Kungah Nfor, Feras Nachmi Alazi, Marcel Leo De Vocht
  • Process for adenovirus purification from high cell density cultures
    Patent number: 8470585
    Abstract: The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA fragmentation and/or precipitation followed by a clarification step with tangential flow filtration.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: June 25, 2013
    Assignee: Crucell Holland B.V.
    Inventors: Marcel Leo De Vocht, Marloes Veenstra
  • Method for the purification of adenovirus particles
    Patent number: 8460920
    Abstract: The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA precipitation followed by a clarification step.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: June 11, 2013
    Assignee: Crucell Holland B.V.
    Inventors: Marcel Leo De Vocht, Marloes Veenstra
  • METHOD FOR THE PURIFICATION OF ADENOVIRUS PARTICLES
    Publication number: 20120202267
    Abstract: The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA precipitation followed by a clarification step.
    Type: Application
    Filed: October 14, 2010
    Publication date: August 9, 2012
    Inventors: Marcel Leo De Vocht, Marloes Veenstra
  • PROCESS FOR ADENOVIRUS PURIFICATION FROM HIGH CELL DENSITY CULTURES
    Publication number: 20120202268
    Abstract: The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA fragmentation and/or precipitation followed by a clarification step with tangential flow filtration.
    Type: Application
    Filed: October 14, 2010
    Publication date: August 9, 2012
    Applicant: Crucell Holland B.V.
    Inventors: Marcel Leo De Vocht, Marloes Veenstra
  • Method of purifying a hydrophobin present in a hydrophobin-containing solution
    Patent number: 6903191
    Abstract: The invention relates to a method of purifying a hydrophobin present in a hydrophobin-containing solution. According to the invention the solution is contacted with a surface for the adsorption to that surface, and separated from a solution depleted in hydrophobin. Subsequently the surface is contacted with a solution containing a surfactant at a temperature lower than 90° C. Desorbed hydrophobin is separated from said surface.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: June 7, 2005
    Assignee: Applied NanoSystems B.V.
    Inventors: Marcel Leo de Vocht, Herman Abel B. Wösten, Joseph Gerard H. Wessels
  • Method of purifying a hydrophobin present in a hydrophobin-containing solution
    Publication number: 20030166960
    Abstract: The invention relates to a method of purifying a hydrophobin present in a hydrophobin-containing solution. According to the invention the solution is contacted with a surface for the adsorption to that surface, and separated from a solution depleted in hydrophobin. Subsequently the surface is contacted with a solution containing a surfactant at a temperature lower than 90° C. Desorbed hydrophobin is separated from said surface.
    Type: Application
    Filed: November 25, 2002
    Publication date: September 4, 2003
    Inventors: Marcel Leo de Vocht, Herman Abel B. Wosten, Joseph Gerard H. Wessels
  • Method of treating a surface of an object with a hydrophobin-containing solution
    Publication number: 20030134042
    Abstract: The invention relates to a method of treating a surface of an object with a hydrophobin-containing solution for providing the surface with a hydrophobin coating, the object being chosen from the group consisting of a window, a contact lens, a biosensor, a medical device, a container for performing an assay or storage, the hull of a vessel or a frame or bodywork of a car, and a solid particle whereby the surface of said object after being coated with hydrophobin is treated at a temperature of at least 30° C.
    Type: Application
    Filed: October 29, 2002
    Publication date: July 17, 2003
    Inventors: Marcel Leo de Vocht, Herman Abel B. Wosten, Joseph Gerard H. Wessels
  • Method of stabilizing a hydrophobin-containing solution and a method of coating a surface with a hydrophobin
    Publication number: 20030113454
    Abstract: The invention relates to a method of stabilizing a hydrophobin-containing solution. According to the present invention, the hydrophobin is subjected to a treatment with a disulphide bridge-cleaving agent to yield unfolded hydrophobin, said treatment involving the prevention of the formation of disulphide bridges from cleaved disulphide bridges. The invention also relates to a method for coating a surface with a stabilized hydrophobin according to the present invention.
    Type: Application
    Filed: October 29, 2002
    Publication date: June 19, 2003
    Inventors: Marcel Leo de Vocht, Hermann Abel B Wsten, George Thomas Robillard, Joseph Gerard H Wessels