Patents by Inventor Marcel Margulies
Marcel Margulies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100112683Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: December 4, 2007Publication date: May 6, 2010Applicant: Applied Biosystems, LLCInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20090155765Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: November 5, 2008Publication date: June 18, 2009Applicant: Applied Biosystems Inc.Inventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Rahusa, Richard Leath, Clive Miles
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Patent number: 7504241Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: GrantFiled: May 12, 2006Date of Patent: March 17, 2009Assignee: Applied Biosystems, LLCInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20080299651Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: December 4, 2007Publication date: December 4, 2008Applicant: Applera CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20080138887Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: June 12, 2008Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Patent number: 7238517Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: GrantFiled: October 22, 2003Date of Patent: July 3, 2007Assignee: Applera CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20060286659Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: December 21, 2006Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20060269641Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: November 30, 2006Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20050084957Abstract: A sample tube including a cylindrical part and a conical part is described. The cylindrical part can include, a first wall portion having a first wall portion thickness, a second wall portion having a second wall portion thickness, and a shoulder including a planar first surface and a conically beveled second surface disposed between the first wall portion and the second wall portion. The first wall portion can be disposed closer to the planar first surface than the conically beveled second surface. The conical part can be shaped as a frustrum of a cone having a conical part wall thickness. The frustrum can include a wider-end and a narrower-end. The wider-end of the frustrum can be in contact with the second wall portion of the cylindrical part. At least one of the first wall portion thickness and the second wall portion thickness can be greater than the conical part wall thickness.Type: ApplicationFiled: August 30, 2004Publication date: April 21, 2005Applicant: Applera CorporationInventors: John Atwood, Susan Stone, Judith Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20040248146Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: ApplicationFiled: October 22, 2003Publication date: December 9, 2004Applicant: Applera CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams Brookfield, Marcel Margulies, Robert P. Ragusa, Richard Leath, Timothy M. Woudenberg, Clive Miles
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Publication number: 20040086927Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: ApplicationFiled: October 22, 2003Publication date: May 6, 2004Applicant: Applera Corporation, a DE corporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Patent number: 6170984Abstract: The invention is directed to a differential analysis method and apparatus wherein a sample and reference are subjected to an externally applied disturbance, such as temperature change, in accord with a prescribed function comprising the sum of a linearly changing part and a periodically changing part, and the measured differential signal is processed into real and imaginary components relating, respectively, to the energy storage and energy loss portions of the signal.Type: GrantFiled: April 23, 1998Date of Patent: January 9, 2001Assignee: PerkinElmer Instruments LLCInventors: J{umlaut over (u)}rgen Schawe, Marcel Margulies
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Patent number: 5710381Abstract: A two-piece plastic holder for loosely holding microliter sample tubes of a preselected design, each tube having a cylindrically shaped upper section open at its top end, a closed, tapered lower section extending downwardly therefrom, and a circumferential shoulder extending outwardly from the upper section at a position on the upper section spaced from the open end thereof. The holder includes a one-piece tray member and a one-piece retainer. The one-piece tray member including a flat, horizontal plate section containing holes in a rectangular array, a first vertical tray sidewall section around the plate extending upwardly to a height greater than the height of a tube resting in one of the holes, and a second vertical tray sidewall section around the plate extending downwardly approximately to the bottom of the upper section of a tube resting in one of the holes. The one-piece retainer is releasably engageable inside the tray over any sample tubes resting in the tray.Type: GrantFiled: March 1, 1994Date of Patent: January 20, 1998Assignee: The Perkin-Elmer CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Patent number: 5671603Abstract: An apparatus for controlling level of cryogenic liquid in a vessel includes a transfer duct to a pressure supply tank. Pressure pulses are applied to the tank at one rate when the level is below a primary sensor in the vessel, and at a lower rate when the level is above the sensor, so as to compensate for intrinsic declination of the level. At startup a constant pressure is applied to the tank until the level reaches a lower sensor, and a relief valve over the tank is opened when the level overshoots to an upper sensor. Turbulence in the vessel is reduced by a pair of coaxial baffles at the liquid inlet to the vessel, and by a housing with tubular extensions enveloping the sensors.Type: GrantFiled: December 8, 1995Date of Patent: September 30, 1997Assignee: The Perkin-Elmer CorporationInventors: E. Joel McCorkle, Herman Vogel, Marcel Margulies, Richard T. Ferranti
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Patent number: 5602756Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: GrantFiled: December 8, 1995Date of Patent: February 11, 1997Assignee: The Perkin-Elmer CorporationInventors: John G. Atwood, Albert C. Mossa, Lisa M. Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Patent number: 5549387Abstract: The invention is directed to a differential analysis method and apparatus wherein a sample and reference are subjected to an externally applied disturbance, such as temperature change, in accord with a prescribed function comprising the sum of a linearly changing part and a periodically changing part, and the measured differential signal is processed into real and imaginary components relating, respectively, to the energy storage and energy loss portions of the signal.Type: GrantFiled: June 1, 1994Date of Patent: August 27, 1996Assignee: The Perkin-Elmer CorporationInventors: Jurgen Schawe, Marcel Margulies
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Patent number: 4985626Abstract: A mass filter for charged particles includes a cylindrical conductive housing at ground potential and an array of linear conductors arranged in parallel in the housing and divided equally into four subarrays. The conductors of each subarray lie in one of four planes having a tubular arrangement with a square cross section on the longitudinal axis of the housing. The conductors have a substantially uniform distribution in the planes. A dedicated voltage is applied to each conductor in each subarray, the voltages being selected cooperatively and with the dimensions of the housing and the square cross section, such that a quadrupole type of electric field is generated within the tubular arrangement. Equations are disclosed for determining the voltages.Type: GrantFiled: January 9, 1990Date of Patent: January 15, 1991Assignee: The Perkin-Elmer CorporationInventor: Marcel Margulies
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Patent number: D412991Type: GrantFiled: January 16, 1997Date of Patent: August 17, 1999Assignee: The Perkin-Elmer Corp.Inventors: Michael P DiVito, Ernest M. Bevilacqua, Marcel Margulies, E. Joel McCorkle, Ralph W. Keese, Donald G. Mackay