Abstract: This present invention provides anti-C—C chemokine type 8 (CCR8) antibodies and antigen binding fragments thereof, methods of making the antibodies or antigen binding fragments thereof, and methods of use thereof to bind to human CCR8 on CCR8 expressing cells, e.g., tumor-infiltrating Treg cells, to remove CCR8 expressing cells, e.g, tumor-infiltrating Treg cells, to reduce or inhibit tumor growth and/or to treat cancer.

Abstract: A piezoelectric mechanism is disclosed that is normally depressible but would not produce a spark, unless a latch member is first activated to engage the plexor relative to the piezoelectric system, so that when the piezoelectric mechanism is compressed, the plexor is released to impact the piezoelectric system to produce a spark to ignite fuel gas.

Abstract: It comprises a telescopic assembly formed by a first internal body (1A) and a second external body (2A-2E), the piezoelectric assembly being housed inside and wherein is fixed a piezoelectric crystal which, when struck by the striker hammer (3) appropriately movably guided within the internal telescopic body (1A), produces the gas lighting spark. The second external telescopic body (2A-2E) is closed externally in order to avoid the incoming of foreign elements which could cause problems to the operation of the mechanism The diametral projections of the striker (3) are actuated by first (25) and second (28) ramps, as well as by longitudinal voids (32) provided in opposite walls of said external telescopic body (2A-2E), said ramps guiding the striker (3) both in the assembly process and in the triggering resetting of said striker.

Abstract: The piezoelectric ignition mechanism of the present invention has a telescopic assembly having an inner and an outer members aided by a return spring for maintaining a maximum extension between the members. The inner member includes a piezoelectric element which is immobilized between an anvil and impact pad over which a plexor strikes to generate a spark. An impact spring for aiding the plexor is guided in the interior of the telescopic assembly and is disposed between the plexor and an end member connected to the outer telescopic member. A resistant spring is also disposed at or near the end member to provide additional resistance to the operation of the piezoelectric mechanism in order to discourage the undesirable operation by young users.

Abstract: This mechanism of the invention has two telescopic assemblies (1, 2) aided by a spring (20) for maintaining a maximum extension position between the assemblies. The interior assembly (1) includes a piezoelectric element (3) which is immobilized between an anvil (4) and a limiting piece (5) over which a plexor (6) hits to generate the lighting spark. The external telescopic assembly (2) is prevented from rotation relative to the internal one (1) by an angular piece (22) having orthogonal flanks. One flank of this angular piece has a central slot forming two lugs (24), which enter respective parallel notches (23) of the internal telescopic assembly (1) when crossing its wall. The other flank contacts one of the external faces of the other telescopic assembly. The spring (20) is external and is axially distant from the piezoelectric element (3).

Abstract: Of the type that include two telescopic bodies (1, 2) aided by a spring (17) which keeps them extended, there being inside the former the piezoelectric element (3) immobilized between an anvil (4) and the stop piece (6) upon which a firing hammer (8) strikes generating the spark.The outside telescopic body (2) includes a pair of ribs (22) which emerge from diametrically opposite points of the cylindric surface of its axial recess, which guide the telescopic displacement of the other body (1) upon introducing themselves in respective longitudinal grooves (12) of the body, in which the diametric projections (10) of the guide of the firing hammer (8) play.The body (2) has in its end opposite the emergence of the body (1) with a widened axial recess where there is a pair of confronting windows in which a cover (14) is secured in which springs (13, 17) which aid the firing hammer and telescopic body (1) are included.