Patents by Inventor Marcel Muller

Marcel Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4131655
    Abstract: D-homopregnanes of the formula ##STR1## wherein R.sup.6 is hydrogen, chloro, fluoro or methyl; X is .beta.-hydroxymethylene or carbonyl; R.sup.17a is hydroxy, lower alkanoyloxy or aroyloxy; R.sup.21 is hydrogen, chloro, fluoro, hydroxy, lower alkanoyloxy, aroyloxy, sulfate or phosphate; and the dotted line in the 1,2-position of the A-ring denotes an additional carbon-carbon bondAnd pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them as the active ingredient are disclosed. The D-homopregnanes of the present invention exhibit hormonal activity and are useful for the treatment of inflammation.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: December 26, 1978
    Assignee: Hoffman-La Roche Inc.
    Inventors: Leo Alig, Andor Furst, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
  • Patent number: 4057561
    Abstract: D-homosteroids of the formula ##STR1## WHEREIN R.sup.3.alpha. is hydrogen, R.sup.3.beta. is hydroxy, lower alkanoyloxy or aroyloxy and R.sup.3.alpha. and R.sup.3.beta. taken together are oxo; R.sup.17a.alpha. is hydrogen, lower alkyl, ethynyl, vinyl, allyl, methallyl, propadienyl, 1-propynyl, butadiynyl or chloroethynyl; R.sup.17a.beta. is hydrogen, alkanoyl, aroyl, lower alkyl, cycloalkyl-lower-alkyl, benzyl, furfuryl or tetrahydropyranyl; R.sup.18 is hydrogen or methyl and the dotted line in the C-ring denotes an additional carbon to carbon bond in the 11,12-position andProcesses for the preparation thereof are disclosed.The D-homosteroids of the present invention are useful as ovulation inhibitors and androgenic/anabolic agents.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: November 8, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Jurg Gutzwiller, Marcel Muller, Rudolf Wiechert, Ulrich Eder, Gunter Neef
  • Patent number: 4036874
    Abstract: D-homosteroids of the formula ##STR1## wherein R.sup.6 is hydrogen, fluorine, chlorine or methyl; R.sup.9 is hydrogen, fluorine, chlorine or bromine; R.sup.17 and R.sup.21 each independently are hydroxy or acyloxy, and U represents optional olefinic unsaturation are endocrine agents having anti-inflammatory properties.
    Type: Grant
    Filed: December 11, 1975
    Date of Patent: July 19, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Leo Alig, Andor Furst, Marcel Muller
  • Patent number: 4034155
    Abstract: A writing pen capacitively detects and amplifies signals generated by a writing table that produces a varying electrostatic field near its writing surface. The pen cartridge, which senses the signal, is capacitively coupled to a concentric electrode, from which the signal which has been detected may be obtained for amplification.
    Type: Grant
    Filed: April 19, 1976
    Date of Patent: July 5, 1977
    Assignee: Telautograph Corporation
    Inventors: Alex Marcel Muller, Joseph Leslie Tyrrell
  • Patent number: 4029692
    Abstract: The present disclosure relates to steroid carboxylic acids and derivatives thereof. More particularly, the disclosure is concerned with D-homosteroid carboxylic acids and their derivatives, a process for the preparation thereof and pharmaceutical compositions containing same. The instant compounds are active endocrinal agents, especially as antiinflammatory agents.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: June 14, 1977
    Inventors: Leo Alig, Robert Nickolson, Rudolf Wiechert, Andor Furst, Klaus Kieslich, Marcel Muller, Ulrich Kerb
  • Patent number: 4028400
    Abstract: The present invention relates to steroids. More particularly, the invention is concerned with D-homosteroids, a process for the manufacture thereof and pharmaceutical preparations containing same.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: June 7, 1977
    Inventors: Leo Alig, Andor Furst, Peter Keller, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
  • Patent number: 4026922
    Abstract: The present disclosure relates to novel D-homo-pregnene steroids useful as progestational agents.
    Type: Grant
    Filed: October 2, 1975
    Date of Patent: May 31, 1977
    Inventors: Leo Alig, Andor Furst, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
  • Patent number: 4026918
    Abstract: Novel D-homosteroids of the formula ##STR1## are disclosed. The novel D-homosteroids exhibit anti-inflammatory activity and are useful intermediates for the synthesis of anti-inflammatory D-homosteroids.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: May 31, 1977
    Inventors: Andor Furst, Marcel Muller, Leo Alig, Peter Keller, Ulrich Kerb, Rudolf Wiechert, Klaus Kieslich, Karl Petzoldt
  • Patent number: 4026921
    Abstract: Novel D-homosteroids of the formula ##STR1## are disclosed. These compounds exhibit anti-inflammatory activity.
    Type: Grant
    Filed: September 20, 1974
    Date of Patent: May 31, 1977
    Inventors: Andor Furst, Marcel Muller, Leo Alig, Peter Keller, Ulrich Kerb, Rudolf Wiechert, Klaus Kieslich, Karl Petzoldt
  • Patent number: 4026923
    Abstract: A novel class of D-homosteroids is disclosed. These compounds have potent endocrinal activity, particularly as anti-inflammatory agents.
    Type: Grant
    Filed: November 6, 1975
    Date of Patent: May 31, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Leo Alig, Andor Furst, Marcel Muller
  • Patent number: 3984476
    Abstract: D-Homosteroids of the formula ##SPC1##Wherein R.sup.3 .alpha. is hydrogen, R.sup.3 .beta. is hydrogen, lower alkanoyloxy or aroyloxy and R.sup.3 .alpha. and R.sup.3 .beta. taken together are oxo; R.sup.13 is lower alkyl; R.sup.17a .beta. is hydrogen, lower alkanoyl, aroyl or lower alkyl; R.sup.17a .alpha. is hydrogen, lower alkyl, ethynyl, 1-propynyl, vinyl, chloroethynyl, butadiynyl or propadienyl and the dotted line in the A-ring denotes an additional carbon bond in either the 4,5- or 5(10)-position and processes for the preparation thereof are disclosed.The D-homosteroids of the present invention are useful as contraceptives and regulators of the female menstrual cycle.
    Type: Grant
    Filed: October 14, 1975
    Date of Patent: October 5, 1976
    Inventors: Andor Furst, Marcel Muller, Jurg Albert Walter Gutzwiller, Ulrich Kerb, Rudolf Wiechert
  • Patent number: 3965128
    Abstract: New 6.beta.,7.beta.-epoxy-17.alpha.-hydroxy or acyloxy-1.alpha.,2.alpha.-methylen-D-homo-4-pregnen-3,20-diones having surprising progestational activity are disclosed.
    Type: Grant
    Filed: September 23, 1974
    Date of Patent: June 22, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andor Furst, Marcel Muller, Leo Alig, Peter Keller, Ulrich Kerb, Rudolf Wiechert
  • Patent number: 3939193
    Abstract: A novel class of D-homosteroids is disclosed. These compounds have potent endocrinal activity, particularly as anti-inflammatory agents.
    Type: Grant
    Filed: August 29, 1974
    Date of Patent: February 17, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Leo Alig, Andor Furst, Marcel Muller
  • Patent number: 3931268
    Abstract: Benzene-ring substituted (2-methylhydrazino)methylbenzene compounds and intermediates therefor are described. The former compounds are useful as cytostatic agents.
    Type: Grant
    Filed: May 6, 1970
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Bollag, Hugo Gutmann, Balthasar Hegedus, Ado Kaiser, Albert Langemann, Marcel Muller, Paul Zeller