Abstract: A system an d method of coupling light in and out of an optical member is described which includes transmitting at least one light beam within a wavelength range of infrared, visible or ultraviolet light using a light source; coupling the light beam into a proximal end of the optical member by means of at least one focussing optical component; collecting backscattered light using a distal end of the optical member and emitting the collected light at the proximal end of the optical member and wherein the light emitted by the optical member has at least partially a different angular sector than an angular sector of the light beam being coupled into the proximal end of the optical member, and detecting the collected light emitted from the proximal end of the optical member using at least one light detector.

Abstract: A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.

Abstract: A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.

Abstract: A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.

Abstract: A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.

Abstract: A system and method for interactive interstitial photo-dynamic tumour therapy and/or photothermal tumour therapy of a human or animal, said system comprising at least one radiation distributor, which is arranged for distribution of optical radiation from at least one radiation source to a reaction site, or from the reaction site to at least one radiation sensor. The radiation distributor comprises at least one translatory displacement element being translatory movable relatively to another element. First ends of first radiation conductors are fixed to the first translatory displacement element and first ends of second radiation conductors are fixed to the other element, wherein the first and the second radiation conductors are connectable to each other in different constellations through translatory movement of the translatory displacement element and the other element relative each other in order to obtain different operation modes of said system.

Abstract: A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumor site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumor therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.

Abstract: A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.