Patents by Inventor Marcin Warminski

Marcin Warminski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL MRNA 5'-END CAP ANALOGS MODIFIED WITHIN PHOSPHATE RESIDUES, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE OR PEPTIDE
    Publication number: 20230295215
    Abstract: The invention relates to new 5?mRNA end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method translates the RNA molecule.
    Type: Application
    Filed: February 12, 2021
    Publication date: September 21, 2023
    Inventors: Marcin WARMINSKI, Pawel SIKORSKI, Joanna KOWALSKA, Jacek JEMIELITY
  • 5'-Phosphorothiolate mRNA 5'-end (cap) Analogs, mRNA Comprising the Same, Method of Obtaining and Uses Thereof
    Publication number: 20190300563
    Abstract: The present invention relates to nucleotides, analogs of mRNA 5?-end (cap) containing sulfur atom at the position 5? of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, which modulate their affinity for DcpS enzyme.
    Type: Application
    Filed: January 27, 2017
    Publication date: October 3, 2019
    Inventors: Jacek Jemielity, Kaja Fac-Dabrowska, Blazej Wojtczak, Marek Baranowski, Anna Nowicka, Joanna Kowalska, Pawel Sikorski, Marcin Warminski