Patents by Inventor Marco A. Krumbuegel
Marco A. Krumbuegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220334065Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.Type: ApplicationFiled: July 5, 2022Publication date: October 20, 2022Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
-
Publication number: 20220276169Abstract: A system includes: an objective lens; a first light source to feed first illuminating light through the objective lens and into a flowcell (e.g., with a relatively thin film waveguide) to be installed in the system, the first illuminating light to be fed using a first grating on the flowcell; and a first image sensor to capture imaging light using the objective lens, wherein the first grating is positioned outside a field of view of the first image sensor. Dual-surface imaging can be performed. Flowcells with multiple swaths bounded by gratings can be used. An auto-alignment process can be performed.Type: ApplicationFiled: May 16, 2022Publication date: September 1, 2022Inventors: Yinghua Sun, Stanley S. Hong, Frederick Erie, Alex Nemiroski, M. Shane Bowen, Danilo Condello, Dietrich Dehlinger, Marco A. Krumbuegel, Anthony Lam, Aaron Liu, Bojan Obradovic, Mark Pratt
-
Patent number: 11408828Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.Type: GrantFiled: June 18, 2020Date of Patent: August 9, 2022Assignee: ILLUMINA, INC.Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
-
Patent number: 11360027Abstract: A system includes: an objective lens; a first light source to feed first illuminating light through the objective lens and into a flowcell (e.g., with a relatively thin film waveguide) to be installed in the system, the first illuminating light to be fed using a first grating on the flowcell; and a first image sensor to capture imaging light using the objective lens, wherein the first grating is positioned outside a field of view of the first image sensor. Dual-surface imaging can be performed. Flowcells with multiple swaths bounded by gratings can be used. An auto-alignment process can be performed.Type: GrantFiled: March 12, 2019Date of Patent: June 14, 2022Assignee: Illumina, Inc.Inventors: Yinghua Sun, Stanley S. Hong, Frederick Erie, Alex Nemiroski, M. Shane Bowen, Danilo Condello, Dietrich Dehlinger, Marco A. Krumbuegel, Anthony Lam, Aaron Liu, Bojan Obradovic, Mark Pratt
-
Publication number: 20200319115Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.Type: ApplicationFiled: June 18, 2020Publication date: October 8, 2020Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
-
Patent number: 10774371Abstract: Imaging systems including an objective lens and a line generation module are described herein. The objective lens may focus a first light beam emitted by the line generation module and a second light beam emitted by the line generation module at a focal point external to a sample so as to adjust line width. Line width may be increased to lower overall power density of a light beam on a surface of the sample such that the power density of the light beam on the surface of the sample is below a photosaturation threshold of a dye on the sample.Type: GrantFiled: March 6, 2018Date of Patent: September 15, 2020Assignee: ILLUMINA, INC.Inventors: Yinghua Sun, Stanley S. Hong, Marco A. Krumbuegel, Peter Clarke Newman, Simon Prince, Dakota Watson, Wenyi Feng, Andrew James Carson, Frederick Erie
-
Patent number: 10732122Abstract: A system for biological sample analysis includes a plurality of modular subassemblies and a precision mounting plate, wherein each modular subassembly includes an enclosure and a plurality of optical components pre-aligned to the enclosure, and the enclosure includes a plurality of precision mounting structures, and each modular subassembly is mechanically coupled to the precision mounting plate, such that each precision mounting structure from a modular subassembly attaches directly to a corresponding precision mounting structure located on the precision mounting plate or an adjacent modular subassembly to optimize optomechanical tolerance.Type: GrantFiled: December 19, 2017Date of Patent: August 4, 2020Assignee: ILLUMINA, INC.Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
-
Publication number: 20190302024Abstract: A system includes: an objective lens; a first light source to feed first illuminating light through the objective lens and into a flowcell (e.g., with a relatively thin film waveguide) to be installed in the system, the first illuminating light to be fed using a first grating on the flowcell; and a first image sensor to capture imaging light using the objective lens, wherein the first grating is positioned outside a field of view of the first image sensor. Dual-surface imaging can be performed. Flowcells with multiple swaths bounded by gratings can be used. An auto-alignment process can be performed.Type: ApplicationFiled: March 12, 2019Publication date: October 3, 2019Inventors: Yinghua Sun, Stanley S. Hong, Frederick Erie, Alex Nemiroski, M. Shane Bowen, Danilo Condello, Dietrich Dehlinger, Marco A. Krumbuegel, Anthony Lam, Aaron Liu, Bojan Obradovic, Mark Pratt
-
Publication number: 20180258468Abstract: Imaging systems including an objective lens and a line generation module are described herein. The objective lens may focus a first light beam emitted by the line generation module and a second light beam emitted by the line generation module at a focal point external to a sample so as to adjust line width. Line width may be increased to lower overall power density of a light beam on a surface of the sample such that the power density of the light beam on the surface of the sample is below a photosaturation threshold of a dye on the sample.Type: ApplicationFiled: March 6, 2018Publication date: September 13, 2018Inventors: YINGHUA SUN, Stanley S. Hong, Marco A. Krumbuegel, Peter Clarke Newman, Simon Prince, Dakota Watson, Wenyi Feng, Andrew James Carson, Frederick Erie
-
Publication number: 20180188183Abstract: A system for biological sample analysis includes a plurality of modular subassemblies and a precision mounting plate, wherein each modular subassembly includes an enclosure and a plurality of optical components pre-aligned to the enclosure, and the enclosure includes a plurality of precision mounting structures, and each modular subassembly is mechanically coupled to the precision mounting plate, such that each precision mounting structure from a modular subassembly attaches directly to a corresponding precision mounting structure located on the precision mounting plate or an adjacent modular subassembly to optimize optomechanical tolerance.Type: ApplicationFiled: December 19, 2017Publication date: July 5, 2018Inventors: Wenyi Feng, Simon Prince, Peter Clarke Newman, Dakota Watson, Stanley S. Hong, Marco A. Krumbuegel, Yinghua Sun, Andrew James Carson, Merek C. Siu
-
Patent number: 6008899Abstract: Practical third-order frequency-resolved optical grating (FROG) techniques for characterization of ultrashort optical pulses are disclosed. The techniques are particularly suited to the measurement of single and/or weak optical pulses having pulse durations in the picosecond and subpicosecond regime. The relative quantum inefficiency of third-order nonlinear optical effects is compensated for through i) use of phase-matched transient grating beam geometry to maximize interaction length, and ii) use of interface-enhanced third-harmonic generation.Type: GrantFiled: June 18, 1997Date of Patent: December 28, 1999Assignee: Sandia CorporationInventors: Rick P. Trebino, Thomas Tsang, David N. Fittinghoff, John N. Sweetser, Marco A. Krumbuegel
-
Patent number: 5978091Abstract: An apparatus for measuring the height and diameter of laser-zone texture bumps on a rigid magnetic disk substrate is disclosed. The apparatus has a disk holder for supporting and rotating the substrate, and an optical beam-source assembly for directing a focused laser beam on the substrate, and for shifting the position of the beam's illumination spot on the substrate in a tracking (radial) direction. An optical detection assembly in the apparatus measures the deflection of the laser beam due to specular reflection of the beam by laser-zone texture bumps, as a function of time, in both scanning (circumferential) and tracking directions.Type: GrantFiled: June 26, 1998Date of Patent: November 2, 1999Assignee: HMT Technology CorporationInventors: Peter C. Jann, Marco A. Krumbuegel, Reginald Lee, Ming M. Yang