Patents by Inventor Marco Angelo Bianchessi
Marco Angelo Bianchessi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230039883Abstract: A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.Type: ApplicationFiled: October 18, 2022Publication date: February 9, 2023Applicant: STMICROELECTRONICS S.r.l.Inventors: Marco Angelo BIANCHESSI, Lillo RAIA
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Patent number: 11491489Abstract: A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.Type: GrantFiled: December 21, 2018Date of Patent: November 8, 2022Assignee: STMICROELECTRONICS S.r.l.Inventors: Marco Angelo Bianchessi, Lillo Raia
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Publication number: 20220161259Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.Type: ApplicationFiled: February 14, 2022Publication date: May 26, 2022Applicant: STMICROELECTRONICS S.r.l.Inventors: Davide CUCCHI, Marco Angelo BIANCHESSI, Alessandro COCCI, Lillo RAIA, Lorenzo BRUNO, Nadia SERINA, Marco CEREDA, Danilo PIROLA, Pietro FERRARI, Francesco FERRARA, Alessandro Paolo BRAMANTI
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Patent number: 11278897Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.Type: GrantFiled: December 18, 2018Date of Patent: March 22, 2022Assignee: STMICROELECTRONICS S.r.l.Inventors: Davide Cucchi, Marco Angelo Bianchessi, Alessandro Cocci, Lillo Raia, Lorenzo Bruno, Nadia Serina, Marco Cereda, Danilo Pirola, Pietro Ferrari, Francesco Ferrara, Alessandro Paolo Bramanti
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Patent number: 10597716Abstract: A method for sequencing a nucleic acid strand, comprising the steps of: providing a solution containing truncated strands having lengths different from one another terminating with a respective dideoxynucleotide from among ddATP, ddTTP, ddGTP, and ddCTP; functionalizing first masses by a donor molecule and second masses by an acceptor molecule such as to generate a light emission when they come into mutual contact; coupling a first mass to a first end of each truncated strand; coupling the second masses to a respective terminal dideoxynucleotide of each strand; applying an AC electrical field having variable frequencies that are such as to generate, on each second mass, a net movement directed towards the first mass; acquiring a plurality of light radiations for each frequency value; and associating each light radiation acquired to a respective dideoxynucleotide and, thus, to a respective nucleotide base.Type: GrantFiled: December 29, 2016Date of Patent: March 24, 2020Assignee: STMICROELECTRONICS S.R.L.Inventors: Alessandro Paolo Bramanti, Marco Angelo Bianchessi
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Publication number: 20190201898Abstract: A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.Type: ApplicationFiled: December 18, 2018Publication date: July 4, 2019Inventors: Davide CUCCHI, Marco Angelo BIANCHESSI, Alessandro COCCI, Lillo RAIA, Lorenzo BRUNO, Nadia SERINA, Marco CEREDA, Danilo PIROLA, Pietro FERRARI, Francesco FERRARA, Alessandro Paolo BRAMANTI
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Publication number: 20190201905Abstract: A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.Type: ApplicationFiled: December 21, 2018Publication date: July 4, 2019Inventors: Marco Angelo BIANCHESSI, Lillo RAIA
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Patent number: 10190161Abstract: An apparatus for nucleic acid sequencing includes: a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site; and a conveying device, configured to extend the nucleic acid strand and to cause the extended nucleic acid strand to slide through the detection site along a path. The base-detection device includes a plurality of field-effect nanowire detectors, arranged along the path and each including a respective nanowire and nucleic acid probes, which are defined by respective base sequences and are fixed to the respective nanowire.Type: GrantFiled: April 1, 2015Date of Patent: January 29, 2019Assignee: STMICROELECTRONICS S.R.L.Inventors: Marco Angelo Bianchessi, Francesco Ferrara
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Publication number: 20170369943Abstract: A method for sequencing a nucleic acid strand, comprising the steps of: providing a solution containing truncated strands having lengths different from one another terminating with a respective dideoxynucleotide from among ddATP, ddTTP, ddGTP, and ddCTP; functionalizing first masses by a donor molecule and second masses by an acceptor molecule such as to generate a light emission when they come into mutual contact; coupling a first mass to a first end of each truncated strand; coupling the second masses to a respective terminal dideoxynucleotide of each strand; applying an AC electrical field having variable frequencies that are such as to generate, on each second mass, a net movement directed towards the first mass; acquiring a plurality of light radiations for each frequency value; and associating each light radiation acquired to a respective dideoxynucleotide and, thus, to a respective nucleotide base.Type: ApplicationFiled: December 29, 2016Publication date: December 28, 2017Inventors: Alessandro Paolo Bramanti, Marco Angelo Bianchessi
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Patent number: 9765326Abstract: An apparatus for nucleic acid sequencing includes a nanochannel and a conveying device, configured to move a nucleic acid strand through the nanochannel. The conveying device includes: a first electrode, a second electrode, and a third electrode, which are arranged along the nanochannel so as to be in contact with a fluid occupying the nanochannel, the second electrode being arranged between the first electrode and the third electrode; and a control unit configured to apply a first voltage, a second voltage, and a third voltage, respectively, to the first electrode, the second electrode and the third electrode, for controlling movement of the nucleic acid strand through the nanochannel.Type: GrantFiled: April 1, 2015Date of Patent: September 19, 2017Assignee: STMicroelectronics S.r.l.Inventors: Francesco Ferrara, Marco Angelo Bianchessi
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Publication number: 20150284707Abstract: An apparatus for nucleic acid sequencing includes a nanochannel and a conveying device, configured to move a nucleic acid strand through the nanochannel. The conveying device includes: a first electrode, a second electrode, and a third electrode, which are arranged along the nanochannel so as to be in contact with a fluid occupying the nanochannel, the second electrode being arranged between the first electrode and the third electrode; and a control unit configured to apply a first voltage, a second voltage, and a third voltage, respectively, to the first electrode, the second electrode and the third electrode, for controlling movement of the nucleic acid strand through the nanochannel.Type: ApplicationFiled: April 1, 2015Publication date: October 8, 2015Inventors: Francesco Ferrara, Marco Angelo Bianchessi
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Publication number: 20150284792Abstract: An apparatus for nucleic acid sequencing includes: a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site; and a conveying device, configured to extend the nucleic acid strand and to cause the extended nucleic acid strand to slide through the detection site along a path. The base-detection device includes a plurality of field-effect nanowire detectors, arranged along the path and each including a respective nanowire and nucleic acid probes, which are defined by respective base sequences and are fixed to the respective nanowire.Type: ApplicationFiled: April 1, 2015Publication date: October 8, 2015Inventors: Marco Angelo Bianchessi, Francesco Ferrara
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Patent number: 9016936Abstract: A method of calibrating a temperature sensor of a chemical microreactor envisages: determining an airflow along a path in such a way as to cause a thermal exchange between the airflow and a chemical microreactor, which is provided with an on-board temperature sensor and is set along the path; and detecting a temperature in the airflow downstream of the microreactor, in conditions of thermal equilibrium.Type: GrantFiled: December 28, 2011Date of Patent: April 28, 2015Assignee: STMicroelectronics S.r.l.Inventors: Marco Angelo Bianchessi, Alessandro Cocci
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Patent number: 8885166Abstract: An analyzer for biochemical analysis includes a seat for receiving a recipient. A first light source and a second light source illuminate the recipient with a luminous radiation, respectively, in a first excitation band and in a second excitation band, including a first excitation wavelength and a second excitation wavelength of fluorophores of a first type and of a second type. A first image sensor and a second image sensor are oriented so as to receive light emitted by fluorophores contained in the recipient and are, respectively, provided with a first detection filter and a second detection filter, having, respectively, a first detection passband and a second detection passband, including, respectively, a first emission wavelength and a second emission wavelength of the fluorophores of the first type and of the second type.Type: GrantFiled: December 28, 2011Date of Patent: November 11, 2014Assignee: STMicroelectronics S.R.L.Inventors: Marco Angelo Bianchessi, Maria Eloisa Castagna, Federica Guerinoni, Alessandro Cocci
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Publication number: 20130004954Abstract: An analyzer for biochemical analyses includes a seat for receiving a recipient. A first light source and a second light source illuminate the recipient with a luminous radiation, respectively, in a first excitation band and in a second excitation band, including a first excitation wavelength and a second excitation wavelength of fluorophores of a first type and of a second type. A first image sensor and a second image sensor are oriented so as to receive light emitted by fluorophores contained in the recipient and are, respectively, provided with a first detection filter and a second detection filter, having, respectively, a first detection passband and a second detection passband, including, respectively, a first emission wavelength and a second emission wavelength of the fluorophores of the first type and of the second type.Type: ApplicationFiled: December 28, 2011Publication date: January 3, 2013Applicant: STMicroelectronics S.r.I.Inventors: Marco Angelo Bianchessi, Maria Eloisa Castagna, Federica Guerinoni, Alessandro Cocci
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Publication number: 20120170608Abstract: A method of calibrating a temperature sensor of a chemical microreactor envisages: determining an airflow along a path in such a way as to cause a thermal exchange between the airflow and a chemical microreactor, which is provided with an on-board temperature sensor and is set along the path; and detecting a temperature in the airflow downstream of the microreactor, in conditions of thermal equilibrium.Type: ApplicationFiled: December 28, 2011Publication date: July 5, 2012Applicant: STMICROELECTRONICS S.R.L.Inventors: Marco Angelo Bianchessi, Alessandro Cocci
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Patent number: 7989214Abstract: A microreactor includes a shell structure (2, 3), having a bottom wall (2) and a peripheral wall (3); a layer (5), accommodated in the shell structure (2, 3) and having cavities (9, 10) formed therein, the cavities being accessible form outside the shell structure (2, 3); reagents (17), arranged between the bottom wall (2) and the layer (5), at locations corresponding to the cavities (9, 10). The layer (5) is made of a meltable material that is solid at room temperature, has a melting point (TMP) lower than a maximum operative temperature (TMAX) required by reactions performable through the microreactor (1) and is not miscible with water. The melting point (TMP) may be between 50° C. and 70° C. In one embodiment, the melting point (TMP) is lower than a minimum operative temperature (TMIN) required by reactions performable through the microreactor (1).Type: GrantFiled: December 28, 2009Date of Patent: August 2, 2011Assignee: STMicroelectronics S.r.l.Inventors: Marco Angelo Bianchessi, Alessandro Cocci
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Publication number: 20100167414Abstract: A microreactor includes a shell structure (2, 3), having a bottom wall (2) and a peripheral wall (3); a layer (5), accommodated in the shell structure (2, 3) and having cavities (9, 10) formed therein, the cavities being accessible form outside the shell structure (2, 3); reagents (17), arranged between the bottom wall (2) and the layer (5), at locations corresponding to the cavities (9, 10). The layer (5) is made of a meltable material that is solid at room temperature, has a melting point (TMP) lower than a maximum operative temperature (TMAX) required by reactions performable through the microreactor (1) and is not miscible with water. The melting point (TMP) may be between 50° C. and 70° C. In one embodiment, the melting point (TMP) is lower than a minimum operative temperature (TMIN) required by reactions performable through the microreactor (1).Type: ApplicationFiled: December 28, 2009Publication date: July 1, 2010Applicant: STMicroelectronics S.r.l.Inventors: Marco Angelo Bianchessi, Alessandro Cocci