Patents by Inventor Marco F. Cardosi
Marco F. Cardosi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9335291Abstract: Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.Type: GrantFiled: November 18, 2014Date of Patent: May 10, 2016Assignee: LifeScan Scotland LimitedInventors: James Iain Rodgers, Leanne Mills, Marco F. Cardosi, Christopher Philip Leach, James Moffat
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Patent number: 9046480Abstract: The method includes: providing a test strip comprising a reference electrode and a working electrode coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.Type: GrantFiled: March 4, 2013Date of Patent: June 2, 2015Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F. Cardosi, Andrew Gill, Leanne Mills, Christopher Philip Leach
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Publication number: 20150068920Abstract: Described and illustrated herein are one exemplary method and a measurement system having a meter and a test strip. The test strip has a first working electrode, reference electrode and second working electrode. In this method, acceptable fill data from known first current and known second current are used to predict an estimated second current at proximate the second time period (for a given batch of test strips) during the test sequence. The estimated second current at proximate the second time interval is then compared with a measured actual second current at proximate the second time interval during an actual test to determine if the measured actual second current is substantially equal to or within an acceptable percent deviation from the estimated second current so as to determine sufficient volume of a physiological fluid sample in the test strip.Type: ApplicationFiled: November 18, 2014Publication date: March 12, 2015Inventors: James Iain RODGERS, Leanne MILLS, Marco F. CARDOSI, Christopher Philip LEACH, James MOFFAT
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Patent number: 8815076Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.Type: GrantFiled: October 10, 2012Date of Patent: August 26, 2014Assignee: Lifescan Scotland LimitedInventors: Marco F. Cardosi, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patick Dolan, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
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Patent number: 8632664Abstract: A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip.Type: GrantFiled: October 27, 2009Date of Patent: January 21, 2014Assignee: LifeScan Scotland LimitedInventors: Gavin Macfie, Graeme Webster, Marco F. Cardosi, Christopher Philip Leach, Steven Setford, Selwayan Saini
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Publication number: 20130240375Abstract: The method includes: providing a test strip comprising a reference electrode and a working electrode coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.Type: ApplicationFiled: March 4, 2013Publication date: September 19, 2013Applicant: LifeScan Scotland LimitedInventors: Stephen Patrick BLYTHE, Marco F. CARDOSI, Andrew GILL, Leanne MILLS, Christopher Philip LEACH
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Patent number: 8486244Abstract: Described herein is an electrochemical enzymatic analyte test strip and method for making the test strip. The test strip utilizes isolated conductive areas inside the electrodes to define electrode whiskers. The method utilizes laser ablation to define electrode patterns.Type: GrantFiled: December 22, 2009Date of Patent: July 16, 2013Assignee: LifeScan Scotland LimitedInventors: Marco F. Cardosi, Leanne Mills, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
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Patent number: 8460537Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.Type: GrantFiled: September 3, 2009Date of Patent: June 11, 2013Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
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Patent number: 8388821Abstract: Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator.Type: GrantFiled: October 5, 2007Date of Patent: March 5, 2013Assignee: LifeScan Scotland LimitedInventors: Stephen Patrick Blythe, Marco F. Cardosi, Andrew Gill, Leanne Mills, Christopher Philip Leach
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Patent number: 8323467Abstract: A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer.Type: GrantFiled: October 27, 2009Date of Patent: December 4, 2012Assignee: LifeScan Scotland LimitedInventors: Gavin MacFie, Graeme Webster, Marco F. Cardosi, Christopher Philip Leach, Steven Setford, Selwayan Saini
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Patent number: 8293096Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.Type: GrantFiled: January 22, 2010Date of Patent: October 23, 2012Assignee: LifeScan Scotland LimitedInventors: Marco F. Cardosi, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patrick Dolan, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
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Publication number: 20120199497Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a substrate, at least one working electrode disposed on the substrate, a sample-soluble enzymatic reagent layer disposed above the working electrode, a diffusion-controlling layer (DCL) disposed between the at least one working electrode and the sample-soluble enzymatic reagent layer; and a sample-receiving chamber. In addition, the sample-soluble enzymatic reagent layer is configured and constituted for operable solubility in a bodily fluid sample applied to the electrochemical-based analytical test strip and received in the sample-receiving chamber and for electrochemical enzymatic reaction with an analyte in the bodily fluid sample.Type: ApplicationFiled: February 7, 2011Publication date: August 9, 2012Applicant: LifeScan Scotland LimitedInventors: Zuifang Liu, Marco F. Cardosi, Christopher Philip Leach, Scott Sloss
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Patent number: 8025788Abstract: A method for manufacturing an enzymatic reagent ink for use in analytical test strips (such as electrochemical-based analytical test strips configured for the determination of glucose in blood) includes determining a first relationship between wetability of a representative hydrophobic silica material (e.g., a hydrophobic fumed silica material) and at least a first calibration characteristic (for example, a calibration slope) of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In the method, the first relationship defines a minimum wetability that provides an acceptable first calibration characteristic.Type: GrantFiled: April 24, 2009Date of Patent: September 27, 2011Assignee: LifeScan Scotland LimitedInventors: Marco F. Cardosi, Michael O'Connell
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Publication number: 20110162978Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.Type: ApplicationFiled: January 22, 2010Publication date: July 7, 2011Applicant: LifeScan Scotland Ltd.Inventors: Marco F. CARDOSI, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patrick Dolan, Gretchen Anderson, Lorraine Comstock, Mary Mcevoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
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Publication number: 20110094882Abstract: A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip.Type: ApplicationFiled: October 27, 2009Publication date: April 28, 2011Applicant: LifeScan Scotland LimitedInventors: Gavin MACFIE, Graeme WEBSTER, Marco F. CARDOSI, Christopher Philip LEACH, Steven SETFORD, Selwayan SAINI
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Publication number: 20110094896Abstract: A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer.Type: ApplicationFiled: October 27, 2009Publication date: April 28, 2011Applicant: LifeScan Scotland LimitedInventors: Gavin MACFIE, Graeme Webster, Marco F. Cardosi, Christopher Philip Leach, Steven Setford, Selwayan Saini
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Publication number: 20110079522Abstract: A co-facial multi-analyte test strip includes a first insulating layer with an electrically conductive layer disposed thereon. The electrically conductive layer includes a first working electrode with a first analyte contact pad and a second working electrode with a second analyte contact pad. In addition, the first and second working electrodes of the electrically conductive layer are disposed on the first insulating layer in a planar inline configuration. The multi-analyte test strip also includes a patterned spacer layer positioned above the electrically conductive layer, with the patterned spacer layer defining a single bodily fluid sample-receiving chamber therein that overlies the first working electrode and the second working electrode.Type: ApplicationFiled: October 2, 2009Publication date: April 7, 2011Applicant: LifeScan Scotland LimitedInventors: Graeme WEBSTER, Marco F. Cardosi, Selwayan Saini
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Publication number: 20110048972Abstract: A multi-analyte test strip includes a first insulating layer and an electrically conductive layer disposed on the first insulating layer. The electrically conductive layer has a first working electrode with a first analyte contact pad, a shared counter/reference electrode with a counter/reference electrode contact pad, and a second working electrode with a second analyte contact pad. The multi-analyte test strip also includes a second insulating layer disposed above the first insulating layer and a patterned spacer layer positioned between the first insulating layer and the first electrically conductive layer with the patterned spacer layer defining a bodily fluid sample-receiving chamber that overlies the first working electrode, the shared counter/reference electrode and the second working electrode.Type: ApplicationFiled: August 31, 2009Publication date: March 3, 2011Applicant: LifeScan Scotland LimitedInventors: James MOFFAT, Kathryn Macleod, Christopher Philip Leach, Gavin Macfie, Geoffrey Lillie, Marco F. Cardosi
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Publication number: 20110005941Abstract: A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.Type: ApplicationFiled: September 3, 2009Publication date: January 13, 2011Applicant: LifeScan Scotland Ltd.Inventors: Stephen Patrick BLYTHE, Marco F. Cardosi, Leanne Mills, Manuel Alvarez-Icaza, Emma Vanessa Jayne Day, Richard Michael Day, Christopher Philip Leach
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Publication number: 20100270152Abstract: An enzymatic reagent ink includes an amount of hydrophobic silica material (e.g., a fumed silica material), an amount of surfactant (such as a non-ionic surfactant); and an amount of enzyme (for example, glucose oxidase). The amounts of the hydrophobic silica material and the surfactant present in the enzymatic reagent ink is predetermined based on first and second relationships. The first relationship is a relationship between wetability of a representative hydrophobic silica material and a first calibration characteristic of an analytical test strip that includes an enzymatic reagent ink containing the representative hydrophobic silica material. In addition, such a first relationship defines a minimum wetability that provides an acceptable first calibration characteristic. The second relationship is a relationship defining wetability of a mixture of the hydrophobic silica material and a surfactant across a range of relative amounts of the hydrophobic silica material and the surfactant.Type: ApplicationFiled: April 24, 2009Publication date: October 28, 2010Applicant: LifeScan Scotland LimitedInventors: Marco F. CARDOSI, Michael O'CONNELL