Abstract: An interface system (10) for man-machine interaction includes a sensor and actuator arrangement (12) wearable by or coupled to the body (B) of a user. A management unit (14) exchanges data with a control application resident on a remote processing system (PS), to transmit data to the application, indicative of the position and movements of the user in a physical environment, and to transmit sensations to the user, in at least one point of the body of the user, indicative of the interaction with an operating environment. The sensors and actuators are supported by operating modules (16), interfacing on at least one communication channel through respective pairs of input and output communication ports. The operating modules are provided with interconnection devices (18) in such a way as to be assembled to each other into a planar arrangement and/or a stacked arrangement.