Patents by Inventor Marcus E. Kehrli, Jr.

Marcus E. Kehrli, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted heteroaryl- and phenylsulfamoyl compounds
    Patent number: 7262318
    Abstract: The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: August 28, 2007
    Assignee: Pfizer, Inc.
    Inventors: Ernest S. Hamanaka, Marcus E. Kehrli, Jr.
  • Bovine tumor necrosis factor receptor-1 and methods of use
    Patent number: 6939950
    Abstract: The invention relates to nucleic acid sequences encoding a bovine tumor necrosis factor receptor-I (TNF-RI). Also within the invention is a soluble bovine TNF-RI, which is a potent inhibitor of bovine tumor necrosis factor-? (TNF-?). The invention demonstrates that soluble bovine TNF-RI has therapeutic value as an inhibitor of TNF in cattle suffering from coliform mastitis or other inflammatory disease.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: September 6, 2005
    Assignees: Iowa State University Research Foundation, The United States of America as represented by the Department of Agriculture
    Inventors: Michael J. Taylor, Marcus E. Kehrli, Jr., Eun-Kyung Lee, Simon Mwangi
  • Bovine tumor necrosis factor receptor-1 and methods of use
    Patent number: 6406907
    Abstract: The invention relates to nucleic acid sequences encoding a bovine tumor necrosis factor receptor-I (TNF-RI). Also within the invention is a soluble bovine TNF-RI, which is a potent inhibitor of bovine tumor necrosis factor-&agr; (TNF-&agr;). The invention demonstrates that soluble bovine TNF-RI has therapeutic value as an inhibitor of TNF in cattle suffering from coliform mastitis or other inflammatory disease.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: June 18, 2002
    Assignees: Iowa State University Research Foundation, The United States of America as represented by the Secretary of Agriculture, The United States of America as represented by the Department of Agriculture
    Inventors: Michael J. Taylor, Marcus E. Kehrli, Jr., Eun-Kyung Lee
  • Diagnostic assays for genetic mutations associated with bovine leukocyte adhesion deficiency
    Patent number: 5234810
    Abstract: A point mutation in the CD18 gene responsible for causing bovine leukocyte adhesion deficiency (BLAD) and a silent mutation linked thereto have been identified. Nucleic acid sequences encompassing these mutations serve as bases for testing and identifying cattle alleles attributable to BLAD using any of a variety of diagnostic assays. Suitable nucleic acid probes and primers have also been designed for use in such assays.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: August 10, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Marcus E. Kehrli, Jr., Dale E. Shuster