Abstract: The present invention provides molecules comprising a modified Fc region which do not mediate antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) but maintain a long serum half-life due to binding to the neonetal Fc receptor (FcRn). To this end, the molecules of the present invention do not comprise the disulfide bridges of the antibody hinge region but are linked C-terminally by at least two covalent bonds. Furthermore, the molecules of the present invention comprise CH2 domains with an additional disulfide bond.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The invention concerns the use of MGC4504 protein, a functional derivative or fragment thereof, or a nucleic acid coding for said protein, derivative or fragment, for the identification of substances active in preventing or treating a disease associated with or caused by a malfunction of the carbohydrate or lipid metabolism.

Abstract: A method for the selective determination of the scattering index ?s of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light (9) is irradiated into the biological matrix (5) and an intensity measurement value of secondary light (12) exiting at a detection site (33-40) that is located at different measuring distances (?) from the respective light irradiation site (10) during the detection measurements is measured. In order to improve the quality and selectivity of the determination of ?s, the primary light is irradiated obliquely at an angle between 5° and 85° using a contacting light-guiding element.

Abstract: A method for the selective determination of the scattering index ?s of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light (9) is irradiated into the biological matrix (5) and an intensity measurement value of secondary light (12) exiting at a detection site (33-40) that is located at different measuring distances (?) from the respective light irradiation site (10) during the detection measurements is measured. In order to improve the quality and selectivity of the determination of ?s, the primary light is irradiated obliquely at an angle between 5° and 85° using a contacting light-guiding element.

Abstract: A spindle characterization system for characterizing performance of a spindle used in an industrial machine includes a machine base for providing a mounting and support surface and having a recessed portion. The spindle characterization facility includes a table base assembly for supporting the spindle disposed within the recess portion and the table base assembly has a table top and height adjustment mechanism for adjusting the height of the table top. The spindle characterization system also includes a spindle mounting mechanism having a top portion mounted to the spindle and a bottom portion mounted to the table top, and a spindle forcing assembly operatively connected to the spindle, and the spindle forcing assembly generates an axial load, radial load and a torque that is applied to the spindle to simulate a machine tool load.

Abstract: A spindle characterization system for characterizing performance of a spindle used in an industrial machine includes a machine base for providing a mounting and support surface and having a recessed portion. The spindle characterization facility includes a table base assembly for supporting the spindle disposed within the recess portion and the table base assembly has a table top and height adjustment mechanism for adjusting the height of the table top. The spindle characterization system also includes a spindle mounting mechanism having a top portion mounted to the spindle and a bottom portion mounted to the table top, and a spindle forcing assembly operatively connected to the spindle, and the spindle forcing assembly generates an axial load, radial load and a torque that is applied to the spindle to simulate a machine tool load.