Patents by Inventor Marcy E. MacDonald

Marcy E. MacDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Huntingtin DNA, protein and uses thereof
    Patent number: 5693757
    Abstract: A novel gene, huntingtin, is described, encoding huntingtin protein, recombinant vectors and hosts capable of expressing huntingtin. Methods for the diagnosis and treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 2, 1997
    Assignee: The General Hospital Corporation
    Inventors: Marcy E. MacDonald, Christine M. Ambrose, Mabel P. Duyao, James F. Gusella
  • Huntingtin DNA, protein and uses thereof
    Patent number: 5686288
    Abstract: A novel gene, huntingtin, is described, encoding huntingtin protein, recombinant vectors and hosts capable of expressing huntingtin. Methods for the diagnosis and treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: November 11, 1997
    Assignee: The General Hospital Corporation
    Inventors: Marcy E. MacDonald, Christine M. Ambrose, Mabel P. Duyao, James F. Gusella
  • Transport protein gene from the Huntington's disease region
    Patent number: 5538844
    Abstract: The present invention relates, in general, to a novel transport protein, IT10C3. In particular, the present invention relates to nucleic acid molecules coding for IT10C3; IT10C3 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense IT10C3 nucleic acid constructs; antibodies having binding affinity to an IT10C3 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of IT10C3 nucleic acid; a method of detecting IT10C3 nucleic acid or polypeptide in a sample; and kits containing nucleic acid probes or antibodies.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: July 23, 1996
    Assignee: The General Hospital Corporation
    Inventors: Mabel P. Duyao, Marcy E. MacDonald, James F. Gusella
  • DNA encoding a protein-coupled receptor kinase
    Patent number: 5366889
    Abstract: This invention relates to a DNA segment which encodes at least one member of the family of mammalian G protein-coupled receptor kinases, which maps to the Huntington's disease region within the terminal cytogenic subband of the short arm of chromosome 4, 4p16.3, between DNA marker D4S10 and the telomere region. Further, this invention provides the substantially purified expression product of a gene from the Huntington's disease region of the chromosome, as well as related diagnostic and therapeutic uses.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: November 22, 1994
    Assignee: The General Hospital Corporation
    Inventors: Marcy E. MacDonald, James F. Gusella, Christine Ambrose