Patents by Inventor Marek Michalak

Marek Michalak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic and cosmetic uses and applications of calreticulin
    Patent number: 11723954
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: August 15, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: Leslie I. Gold, Marek Michalak
  • Handling of Antenna line Devices in High Layer Split Architecture
    Publication number: 20220191094
    Abstract: A centralized unit of a communication network adopting a high layer split architecture acquires an abstractive model of a plurality of antenna line devices from a distributed unit of the communication network. The centralized unit operates the plurality of antenna line devices by communicating with the distributed unit by using the abstractive model. The distributed unit can perform elementary control of the plurality of antenna line devices based on the communication with the centralized unit.
    Type: Application
    Filed: March 8, 2019
    Publication date: June 16, 2022
    Inventors: Pawel KOCH, Marek MICHALAK
  • THERAPEUTIC AND COSMETIC USES AND APPLICATIONS OF CALRETICULIN
    Publication number: 20210393739
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Application
    Filed: May 14, 2021
    Publication date: December 23, 2021
    Applicant: New York University
    Inventors: Leslie I. GOLD, Marek Michalak
  • Therapeutic and cosmetic uses and applications of calreticulin
    Patent number: 11045521
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: June 29, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Leslie I. Gold, Marek Michalak
  • THERAPEUTIC AND COSMETIC USES AND APPLICATIONS OF CALRETICULIN
    Publication number: 20190343923
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Application
    Filed: March 4, 2019
    Publication date: November 14, 2019
    Applicant: New York University
    Inventors: Leslie I GOLD, Marek MICHALAK
  • Therapeutic and cosmetic uses and applications of calreticulin
    Patent number: 10314888
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing or eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged bone and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering from delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: June 11, 2019
    Assignee: New York University
    Inventors: Leslie I. Gold, Marek Michalak
  • Generation of native recombinant secreted human endoplasmic reticulum chaperones by using their native signal sequences in yeast expression systems
    Patent number: 9796971
    Abstract: A method using yeast as a host for production of human ER chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active. Moreover, secretion allowed simple one-step purification of native recombinant human proteins with high yields.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: October 24, 2017
    Assignee: UAB BALTYMAS
    Inventors: Evaldas Ciplys, Rimantas Slibinskas, Kestutis Sasnauskas, Marek Michalak, Leslie Ina Gold
  • THERAPEUTIC AND COSMETIC USES AND APPLICATIONS OF CALRETICULIN
    Publication number: 20160354438
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing or eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged bone and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering from delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Application
    Filed: January 22, 2016
    Publication date: December 8, 2016
    Applicants: NEW YORK UNIVERSITY, CALREGEN INC.
    Inventors: Leslie I. GOLD, Marek MICHALAK
  • Methods for Treating Diabetic Wounds
    Publication number: 20160310563
    Abstract: The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment.
    Type: Application
    Filed: July 22, 2015
    Publication date: October 27, 2016
    Applicants: NEW YORK UNIVERSITY, CALREGEN INC.
    Inventors: Leslie I. GOLD, Marek MICHALAK
  • Therapeutic and cosmetic uses and applications of calreticulin
    Patent number: 9254310
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing or eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged bone and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering from delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: February 9, 2016
    Assignees: NEW YORK UNIVERSITY, CALREGEN INC.
    Inventors: Leslie I. Gold, Marek Michalak
  • Methods for treating diabetic wounds
    Patent number: 9095550
    Abstract: The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: August 4, 2015
    Assignees: NEW YORK UNIVERSITY, CALREGEN INC.
    Inventors: Leslie I. Gold, Marek Michalak
  • Generation of Native Recombinant Secreted Human Endoplasmic Reticulum Chaperones by Using Their Native Signal Sequences in Yeast Expression Systems
    Publication number: 20150191713
    Abstract: A method using yeast as a host for production of human ER chaperone proteins, using endogenous signal peptides of intracellular human proteins that are recognized and correctly processed in the yeast cells to subsequently lead to the secretion of the human proteins. The resultant proteins possessed native amino acid sequence and were biologically active. Moreover, secretion allowed simple one-step purification of native recombinant human proteins with high yields.
    Type: Application
    Filed: January 12, 2015
    Publication date: July 9, 2015
    Applicant: UAB BALTYMAS
    Inventors: Evaldas Ciplys, Rimantas Slibinskas, Kestutis Sasnauskas, Marek Michalak, Leslie Ina Gold
  • THERAPEUTIC AND COSMETIC USES AND APPLICATIONS OF CALRETICULIN
    Publication number: 20130150285
    Abstract: Therapeutic and cosmetic uses and applications of calreticulin are provided. In particular, the invention relates to therapeutic and cosmetic uses and applications of calreticulin to a patient in need of such treatment including in tissue repair, wound healing, ulcers, reducing scar formation, and reducing or eliminating wrinkles.
    Type: Application
    Filed: June 17, 2011
    Publication date: June 13, 2013
    Applicants: CALREGEN INC., NEW YORK UNIVERSITY
    Inventors: Leslie I. Gold, Marek Michalak
  • Compositions and methods for purifying calreticulin
    Patent number: 8399631
    Abstract: The present invention relates to compositions, methods for expressing, and related methods for purifying calreticulin that is free of an affinity label or tag (i.e., non-tagged calreticulin). The invention provides useful methods for commercial production of human calreticulin in a bacterial expression system such as Escherichia coli.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: March 19, 2013
    Assignee: Calretex LLC
    Inventors: Marek Michalak, Monika Dabroska
  • Methods for Treating Diabetic Wounds
    Publication number: 20130045918
    Abstract: The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment.
    Type: Application
    Filed: February 6, 2012
    Publication date: February 21, 2013
    Applicants: CALREGEN INC., NEW YORK UNIVERSITY
    Inventors: Leslie I. Gold, Marek Michalak
  • Methods for treating diabetic wounds
    Patent number: 8129341
    Abstract: The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: March 6, 2012
    Assignees: New York University, Calregen Inc.
    Inventors: Leslie I. Gold, Marek Michalak
  • COMPOSITIONS AND METHODS FOR PURIFYING CALRETICULIN
    Publication number: 20100145016
    Abstract: The present invention relates to compositions, methods for expressing, and related methods for purifying calreticulin that is free of an affinity label or tag (i.e., non-tagged calreticulin). The invention provides useful methods for commercial production of human calreticulin in a bacterial expression system such as Escherichia coli.
    Type: Application
    Filed: September 11, 2009
    Publication date: June 10, 2010
    Applicant: CALRETEX, LLC
    Inventors: Marek Michalak, Monika Dabroska