Patents by Inventor Margit Sara

Margit Sara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7262281
    Abstract: On a carrier surface, a layer of S-layer proteins is produced as a carrier of functional molecules. A solution containing S-layer proteins in the form of monomers or oligomers is brought into contact with the carrier surface. Electrochemical conditions are produced in the solution such that the S-layer proteins (SU) have an electrical net charge by establishing an electrochemical potential difference between the solution and the carrier surface such that the S-layer proteins accumulate on the carrier surface. A two-dimensional crystalline structure is formed in the layer, and this can occur at a time separate from the deposition of the S-layer proteins, and under different electrochemical conditions.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: August 28, 2007
    Assignee: NANO-S Biotechnologie GmbH
    Inventors: Uwe B. Sleytr, Margit Sara, Wolfgang Kautek
  • Patent number: 7125707
    Abstract: A compound body can be constructed, using secondary cell wall polymers of prokaryotic microorganisms as bonding agent to anchor a monomolecular lattice to a support, with or without functional groups attached to the lattice. The lattice may be comprised of lipid or crystalline cell surface layer proteins. The support is illustrated by a micro-filtration membrane, a cell surface ultra-filtration membrane (SUM), and a micelle, respectively.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: October 24, 2006
    Assignee: Nano-S Biotechnologie GmbH
    Inventors: Uwe B. Sleytr, Margit Sara, Christoph Mader, Bernhard Schuster, Frank M. Unger
  • Publication number: 20040265936
    Abstract: The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the production of modified S-layer proteins are disclosed.
    Type: Application
    Filed: July 14, 2004
    Publication date: December 30, 2004
    Applicants: NANO-S Biotechnologie GmbH
    Inventors: Werner Lubitz, Uwe Sleytr, Beatrix Kuen, Michaela Truppe, Stefan Howorka, Stepanka Resch, Gerhard Schroll, Margit Sara
  • Patent number: 6777202
    Abstract: The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the production of modified S-layer proteins are disclosed.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: August 17, 2004
    Assignees: NANO-S Biotechnologie GmbH
    Inventors: Werner Lubitz, Uwe Sleytr, Beatrix Kuen, Michaela Truppe, Stefan Howorka, Stepanka Resch, Gerhard Schroll, Margit Sara
  • Publication number: 20040137527
    Abstract: On a carrier surface (CP), a layer of cell surface layer proteins (S-layer proteins) (SU, SM, SL) is produced as a carrier of functional molecules by virtue of a solution containing S-layer proteins in the form of monomers (SU) or oligomers (SM) being brought into contact with the carrier surface. To deposit the S-layer proteins, electrochemical conditions are set in the solution at which the S-layer proteins (SU) have an electrical net charge, and by setting the electrical potential of the carrier surface (CP) an electrochemical potential difference is produced between the solution and the carrier surface under whose effect the S-layer proteins from the solution accumulate on the carrier surface. In the layer formed in this way, a two-dimensional crystalline structure (SL) is then configured, wherein this can occur at a time separate from the deposition of the S-layer proteins and under different electrochemical conditions of the solution and/or the substrate.
    Type: Application
    Filed: November 26, 2003
    Publication date: July 15, 2004
    Applicant: NANO-S Biotechnologie GmbH
    Inventors: Uwe B. Sleytr, Margit Sara, Wolfgang Kautek
  • Publication number: 20040033576
    Abstract: Use of secondary cell wall polymer for the directed monomolecular bonding of molecules, preferably molecular layers and/or attachment of molecules to molecules of a support, as well as a compound body completed according to this application.
    Type: Application
    Filed: July 3, 2003
    Publication date: February 19, 2004
    Inventors: Uwe B Sleytr, Margit Sara, Chirstoph Mader, Bernhard Schuster, Frank M Unger
  • Publication number: 20020168728
    Abstract: The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the production of modified S-layer proteins are disclosed.
    Type: Application
    Filed: December 2, 1998
    Publication date: November 14, 2002
    Applicant: ARENT FOX KINTNER PLOTKIN AND KAHN, PLLC
    Inventors: WERNER LUBITZ, UWE SLEYTR, BEATRIX KUEN, MICHAELA TRUPPE, STEFAN HOWORKA, STEPANKA RESCH, GERHARD SCHROLL, MARGIT SARA
  • Patent number: 5028335
    Abstract: Use of novel membrane crystal lattice structures with continuous pores as ultrafiltration membranes, gas separating organs and separating organs for ion exchange processes, structure for immobilizing molecules, and films as enveloping material for substances.
    Type: Grant
    Filed: May 8, 1989
    Date of Patent: July 2, 1991
    Inventors: Uwe Sleytr, Margit Sara
  • Patent number: 4886604
    Abstract: A method for producing a structure comprising at least one membrane with continuous pores having a diameter range of 1 to 8 nm extending along plane, curved, cylindrical or vesicular surfaces consisting essentially of at least one layer of contiguous identical protein containing molecules which molecules are arranged to form a crystal lattice defining continous pores free of said molecules, the membranes being connected to or embedded in a support layer or the membranes being connected together to form a stable unsupported film comprising removing the cell contents from intact cells of microorganisms or breaking the intact cells and separating the membranes or membrane containing cell envelope fragments, suspending the membranes or membrane containing cell envelope fragments in a liquid medium, combining the membranes or membrane containing cell envelope fragments into a layer with a crystal lattice with continuous pores free of the protein containing molecules by depositing the membranes or membrane containi
    Type: Grant
    Filed: August 19, 1986
    Date of Patent: December 12, 1989
    Inventors: Uwe Sleytr, Margit Sara
  • Patent number: 4849109
    Abstract: Use of novel membrane crystal lattice structures with continuous pores as ultrafiltration membranes, gas separating organs and separating organs for ion exchange processes structure for immobilizing molecules, and films as enveloping material for substances.
    Type: Grant
    Filed: March 28, 1988
    Date of Patent: July 18, 1989
    Inventors: Uwe Sleytr, Margit Sara
  • Patent number: 4752395
    Abstract: A structure usable as an ultrafiltration membrane has membranes (20) with continuous pores which are linked to or into an appropriately porous carrier (21). Each of these membranes (20) consist of protein molecules or protein containing molecules arranged according to a two-dimensional crystal lattice, between which continuous pores of equal size and form remain free, and they are advantageously formed from molecules, which were particularly separated from cell-membranes of procaryons, by means of a recrystallization process designated as self-organization, and which are preferably deposited on or into the carrier (21) and are cross-linked with the carrier (21) intra- or intermolecularly, respectively, through foreign molecules.The structure is suitable, furthermore, for use as a separating organ for a gas separation or for an ion exchange process, as well as for use as a carrier structure for other semi-permeable membranes, such as hyperfiltration membranes.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: June 21, 1988
    Inventors: Uwe Sleytr, Margit Sara