Patents by Inventor MARGOT THOME

MARGOT THOME has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Malt1 specific cleavage in assay and screening method
    Patent number: 9051595
    Abstract: The present invention is based on the surprising finding of a proteolytic cleavage function of human Malt1. More particularly, the present invention relates to enzyme and screening assays, methods for assessing cleaving activity, methods for screening, isolated polypeptides, antibodies and inhibitors of Malt1. The present invention also relates to the use of Malt1 as a proteolytic enzyme and the use of compounds comprising a peptide comprising an amino acid sequence according to any one of SEQ ID NO: 1-47 as substrates susceptible for specific proteolytic cleavage.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: June 9, 2015
    Assignee: University of Lausanne
    Inventors: Margot Thome, Fabien Rebeaud, Stephan Hailfinger
  • MALT1 SPECIFIC CLEAVAGE IN ASSAY AND SCREENING METHOD
    Publication number: 20100184709
    Abstract: The present invention is based on the surprising finding of a proteolytic cleavage function of human Malt1. More particularly, the present invention relates to enzyme and screening assays, methods for assessing cleaving activity, methods for screening, isolated polypeptides, antibodies and inhibitors of Malt1. The present invention also relates to the use of Malt1 as a proteolytic enzyme and the use of compounds comprising a peptide comprising an amino acid sequence according to any one of SEQ ID NO: 1-47 as substrates susceptible for specific proteolytic cleavage.
    Type: Application
    Filed: May 30, 2008
    Publication date: July 22, 2010
    Applicant: UNIVERSITY OF LAUSANNE
    Inventors: Margot Thome, Fabien Rebeaud, Stephan Hailfinger
  • Flip genes and flip proteins
    Publication number: 20050084876
    Abstract: The invention relates to nucleic acid molecules that include at least one death effector domain, expression vectors the include these nucleic acid molecules, host cells transformed with such vectors, methods for expressing and/or isolating gene products with at least one death effector domain, and purified or isolated gene products or fragments of these gene products that include at least one death effector domain.
    Type: Application
    Filed: April 26, 2004
    Publication date: April 21, 2005
    Inventors: Jurg Tschopp, Martin Irmler, Kay Hofmann, Margot Thome, Veronique Rochat
  • FLIP GENES AND FLIP PROTEINS
    Publication number: 20020095030
    Abstract: The invention relates to nucleic acid molecules that include at least one death effector domain, expression vectors the include these nucleic acid molecules, host cells transformed with such vectors, methods for expressing and/or isolating gene products with at least one death effector domain, and purified or isolated gene products or fragments of these gene products that include at least one death effector domain.
    Type: Application
    Filed: September 30, 1999
    Publication date: July 18, 2002
    Inventors: JURG TSCHOPP, MARGOT THOME, KIMBERLY BURNS, MARTEN IRMLER, MICHAEL HAHNE, MICHAEL SCHROTER, PASCAL SCHNEIDER, JEAN-LUC BODMER, VERONIQUE STEINER, DONATA RIMOLDI, KAY HOFMANN, E. LARS FRENCH