Abstract: Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.

Abstract: Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.