Patents by Inventor Maria Angela Franceschini
Maria Angela Franceschini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11872022Abstract: An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.Type: GrantFiled: February 18, 2019Date of Patent: January 16, 2024Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Maria Angela Franceschini, Stefan Carp, Davide Tamborini, David Boas, Bruce Rosen, Megan Blackwell, Oleg Shatrovoy
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Patent number: 11723547Abstract: A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.Type: GrantFiled: June 21, 2022Date of Patent: August 15, 2023Assignee: The General Hospital CorporationInventors: Jason Sutin, Maria Angela Franceschini, David Boas
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Patent number: 11660010Abstract: Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.Type: GrantFiled: October 22, 2021Date of Patent: May 30, 2023Assignee: The General Hospital CorporationInventors: David Boas, Jason Sutin, Maria Angela Franceschini
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Publication number: 20220361764Abstract: A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.Type: ApplicationFiled: June 21, 2022Publication date: November 17, 2022Applicant: The General Hospital CorporationInventors: Jason Sutin, Maria Angela Franceschini, David Boas
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Publication number: 20220248971Abstract: Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.Type: ApplicationFiled: October 22, 2021Publication date: August 11, 2022Inventors: David Boas, Jason Sutin, Maria Angela Franceschini
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Patent number: 11395602Abstract: A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and. a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.Type: GrantFiled: April 11, 2016Date of Patent: July 26, 2022Assignee: The General Hospital CorporationInventors: Jason Sutin, Maria Angela Franceschini, David Boas
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Patent number: 11089972Abstract: A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, The method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. The method further includes generating a report indicative of the estimated intracranial pressure.Type: GrantFiled: April 11, 2016Date of Patent: August 17, 2021Assignee: The General Hospital CorporationInventors: Jason Sutin, Maria Angela Franceschini, David Boas
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Patent number: 10912504Abstract: There is provided herewith an apparatus, probe, and method for the combination of near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). The apparatus, probe and method allow for the simultaneous detection of NIRS and DCS.Type: GrantFiled: January 14, 2015Date of Patent: February 9, 2021Assignees: CANON U.S.A., INC., THE GENERAL HOSPITAL CORPORATIONInventors: Haruo Nakaji, Maria Angela Franceschini, David Boas, Erin Buckley, Pei-Yi Lin, Stefan Carp
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Publication number: 20200375476Abstract: An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.Type: ApplicationFiled: February 18, 2019Publication date: December 3, 2020Inventors: Maria Angela Franceschini, Stefan Carp, Davide Tamborini, David Boas, Bruce Rosen, Megan Blackwell, Oleg Shatrovoy
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Publication number: 20190053721Abstract: Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.Type: ApplicationFiled: February 24, 2017Publication date: February 21, 2019Applicant: The General Hospital CorporationInventors: David Boas, Jason Sutin, Maria Angela Franceschini
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Publication number: 20180103861Abstract: A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, The method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. The method further includes generating a report indicative of the estimated intracranial pressure.Type: ApplicationFiled: April 11, 2016Publication date: April 19, 2018Inventors: Jason Sutin, Maria Angela Franceschini, David Boas
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Publication number: 20180070830Abstract: The present disclosure generally relates to improvements to systems and methods for measuring the dynamic properties of scattering particles within a medium, including fluid flow. Specifically, the present disclosure relates to systems and methods for time-resolved diffuse correlation spectroscopy. This disclosure provides systems and methods for determining dynamics in a target medium. The systems and methods can utilize time-resolved diffuse correlation spectroscopy.Type: ApplicationFiled: April 11, 2016Publication date: March 15, 2018Inventors: Jason Sutin, Maria Angela Franceschini, David Boas, Juliette Selb
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Publication number: 20180070831Abstract: A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and. a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.Type: ApplicationFiled: April 11, 2016Publication date: March 15, 2018Inventors: Jason Sutin, Maria Angela Franceschini, David Boas
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Publication number: 20160345880Abstract: There is provided herewith an apparatus, probe, and method for the combination of near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). The apparatus, probe and method allow for the simultaneous detection of NIRS and DCS.Type: ApplicationFiled: January 14, 2015Publication date: December 1, 2016Inventors: Haruo Nakaji, Maria Angela Franceschini, David Boas, Erin Buckley, Pei-Yi Lin, Stefan Carp
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Publication number: 20140316218Abstract: Systems and methods for monitoring and/or controlling a brain state of a subject are provided. In certain embodiments, the method includes acquiring physiological data from sensors including electrophysiological sensors and optical sensors, assembling, using data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject, and identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period. The method also includes computing, using data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process, and estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period.Type: ApplicationFiled: April 23, 2014Publication date: October 23, 2014Inventors: Patrick L. Purdon, Emery N. Brown, ShiNung Ching, David A. Boas, Maria Angela Franceschini, Jason Sutin
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Patent number: 6985763Abstract: A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (2). A reduced scattering coefficient and an absorption coefficient are determined for the tissue, with the result that an effective path length can be determined (6). Data processing is performed to calculate amplitudes for the absorption oscillation data that are translated into oxygenated and deoxygenated hemoglobin concentrations for the venous compartment (8). A method of the invention does not required mechanical ventilation devices or venous perturbation. Additional method steps may entail verifying that the measured absorption oscillation data results from the venous compartment.Type: GrantFiled: November 30, 2001Date of Patent: January 10, 2006Assignee: Tufts UniversityInventors: David Boas, Maria Angela Franceschini, Sergio Fantini
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Publication number: 20040122300Abstract: A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (2). A reduced scattering coefficient and an absorption coefficient are determined for the tissue, with the result that an effective path length can be determined (6). Data processing is performed to calculate amplitudes for the absorption oscillation data that are translated into oxygenated and deoxygenated hemoglobin concentrations for the venous compartment (8). A method of the invention does not required mechanical ventilation devices or venous perturbation. Additional method steps may entail verifying that the measured absorption oscillation data results from the venous compartment.Type: ApplicationFiled: February 20, 2004Publication date: June 24, 2004Inventors: David Boas, Maria Angela Franceschini, Sergio Fantini
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Patent number: 6216021Abstract: The present invention involves a time-resolved measurement method for the real time, non-invasive, simultaneous measurement of time-varying and other hemoglobin compartment saturation. This capability achieves absolute pulse oximetry and oximetry for tissue, without calibration based on a population of healthy people. Calculations conducted by the invention use quantitative measurement of tissue absorption spectrum for tissue saturation, and an amplitude of absorption oscillations for the time-varying hemoglobin compartments at various wavelengths. The invention illuminates tissue and senses light at predetermined distances apart on the tissue to be measured. Intensity and phase data are acquired from source-detector pairs to calculate absolute tissue optical properties from time-resolved measurement data, namely, a reduced scattering coefficient and an absorption coefficient.Type: GrantFiled: June 4, 1999Date of Patent: April 10, 2001Assignee: The Board of Trustees of the University of IllinoisInventors: Maria Angela Franceschini, Sergio Fantini, Enrico Gratton
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Patent number: 6192261Abstract: The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.Type: GrantFiled: May 4, 1998Date of Patent: February 20, 2001Assignee: I.S.S. (USA), Inc.Inventors: Enrico Gratton, Sergio Fantini, Maria Angela Franceschini, William Mantulin, Beniamino Barbieri
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Patent number: 5772587Abstract: The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.Type: GrantFiled: November 29, 1995Date of Patent: June 30, 1998Assignees: The Board of Trustees of The University of Illinois, I.S.S. (USA) Inc.Inventors: Enrico Gratton, Sergio Fantini, Maria Angela Franceschini, William Mantulin, Beniamino Barbieri