Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmo

Abstract: The disclosure relates to an implantable ocular drainage device for controlling intraocular pressure (IOP) comprising at least one drainage channel, and at least one magnetic control mechanism. The at least one magnetic control mechanism is a magnetic valve mechanism configured to regulate flow in the at least one drainage channel.

Abstract: A device for testing in vitro tissue comprises a base section and a structure protruding from the base section. The shape and/or cross section of the structure varies with the height of the structure relative to the base section as measured from a height direction, perpendicular to the base section.

Abstract: An intraluminal ultrasound imaging device includes a flexible elongate member configured to be positioned within a body lumen of a patient. An ultrasound imaging assembly is disposed at the distal portion of the flexible elongate member. The ultrasound imaging assembly includes a plurality of acoustic elements and an acoustically-transparent window disposed over the plurality of acoustic elements. The acoustically-transparent window comprising a plurality of layers formed on top of one another. The plurality of layers includes an innermost layer directly contacting the plurality of acoustic elements, an outermost layer opposite the innermost layer, and an adhesive layer. The outermost layer includes a tubing. A hardness of the innermost layer is less than hardnesses of every other layer of the plurality of layers. A hardness of the outermost layer is greater than the hardnesses of every other layer of the plurality of layers.

Abstract: A method for categorizing a substrate subject to a semiconductor manufacturing process including multiple operations, the method including: obtaining values of functional indicators derived from data generated during one or more of the multiple operations on the substrate, the functional indicators characterizing at least one operation; applying a decision model including one or more threshold values to the values of the functional indicators to obtain one or more categorical indicators; and assigning a category to the substrate based on the one or more categorical indicators.

Abstract: An image sensor for immersion lithography, the image sensor including: a grating; an absorber layer on the grating, the absorber layer configured to absorb radiation; and a liquidphobic coating at an upper surface of the image sensor, wherein a protective layer is provided between the absorber layer and the liquidphobic layer, the protective layer being less reactive than the absorber layer to an immersion liquid.

Abstract: A method for categorizing a substrate subject to a semiconductor manufacturing process including multiple operations, the method including: obtaining values of functional indicators derived from data generated during one or more of the multiple operations on the substrate, the functional indicators characterizing at least one operation; applying a decision model including one or more threshold values to the values of the functional indicators to obtain one or more categorical indicators; and assigning a category to the substrate based on the one or more categorical indicators.

Abstract: A curing accelerator composition for building chemical mixtures comprises a mineral constituent and a polymeric water-soluble dispersant. The mineral constituent comprises a semi-ordered calcium silicate hydrate having an apparent crystallite size of 15 nm or less and less than 35% by weight of crystalline phases other than the semi-ordered calcium silicate hydrate. The composition displays a more pronounced accelerating effect than comparative compositions in which the mineral component comprises a calcium silicate hydrate having a higher degree of crystallinity.

Abstract: An imaging device (100) is disclosed comprising an ultrasound transducer array (101, 120, 130) having a plurality of ultrasound transducer elements defining an ultrasound emitting surface of the ultrasound transducer array; and an acoustic window (220) on the ultrasound emitting surface, said acoustic window comprising: a first layer (221) of a hydrocarbon elastomer contacting the ultrasound emitting surface, said first layer further containing an antioxidant; and a second layer (223) of a further hydrocarbon elastomer on the first layer, said second layer having a greater Shore A hardness than the first layer. Also disclosed are an ultrasound imaging system (10) comprising such an imaging device, such as catheter (100), and a method (300) of forming an acoustic window (220) on an ultrasound transducer array (101, 120, 130) for such a device (100).

Abstract: The present application relates to novel substituted heterocyclic carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of breathing difficulties including sleep-induced breathing difficulties such as central and obstructive sleep apnoea, snoring (primary and obstructive snoring), dysphagia, peripheral and cardiac vascular disorders including diabetic microangiopathies and disorders of the peripheral and central nervous system including neurodegenerative and neuroinflammatory disorders.

Abstract: An object, such as a sensor for an immersion lithographic apparatus, has an outer layer which comes in contact with immersion liquid and wherein the outer layer has a composition including a rare earth element. There is also provided an immersion lithographic apparatus having such an object and a method for manufacturing such an object.

Abstract: A 3D gas chromatography (GC) column development is possible by assembly of two parts each being substrates formed by gas tight materials. One part may be a silicon substrate with a snake shaped flow channel structure and the other part may be a glass plate. Both are coated with a column packing comprising polubutadiene, which is also able to glue or bond both parts together, thereby sealing the flow channel, thus forming a GC column. The column packaging can be composed in all kinds of polarity from very hydrophobic till very hydrophilic. In this way the column packing can be tuned on resolution for particular molecules which are interesting to detect, e.g. Octane. The invention is advantageous for micro GC columns.

Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

Abstract: An ultrasound device (10) is disclosed comprising a transducer arrangement (110) and an acoustically transmissive window (150) over said arrangement, said window comprising an elastomer layer (153) having conductive particles dispersed in the elastomer, the elastomer layer having a pressure-sensitive conductivity, the ultrasound device further comprising an electrode arrangement (160) coupled to said elastomer layer and adapted to measure said pressure-sensitive conductivity. An ultrasound system and arrangement including such an ultrasound device are also disclosed.

Abstract: A fluidic device (1) comprises a flow chamber (2) for accommodating a biological specimen on a carrier portion (3) and at least one flow channel (4a, 4b, 4c, 4d) fluidly connected to the flow chamber (2), the fluidic device (1) having a layered structure comprising a bottom plate (5), a cover plate (6) and an insert (7) in between, the insert (7) comprising the carrier portion (3) and a frame portion surrounding the carrier portion (3), and being elastomeric in order to be able to clamp a biological specimen between an incision in the carrier portion (3).

Abstract: A material for culturing cells is disclosed. The material contains a bulk-modified elastomer having a Shore hardness (DIN EN ISO 868) in a range of Shore00 20 to Shore A 80 and comprising a plurality of fatty acid moieties covalently bound to the elastomer bulk, wherein the carboxylic acid groups of said moieties are available on an external surface of said material to provide said binding, and wherein the bulk-modified elastomer is obtained by forming a composition comprising a vinyl-functionalized or a hydride-functionalized elastomer or at least one precursor thereof, a free of saponified unsaturated fatty acid in a range of 0.

Abstract: A pliable cover adapted to cover an active area of an ultrasound probe is described. The ultrasound probe includes a plurality of ultrasound transducer elements. The pliable cover includes a polymer layer that holds a coupling agent (4) that couples the ultrasound transducer elements to a body surface and a regular pattern of channels extending through the pliable cover. An ultrasound probe arrangement is also described and includes the pliable cover. An ultrasound system including the ultrasound probe arrangement, and a method of positioning the ultrasound probe in a region of a body are also described.

Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

Abstract: An acoustic lens suitable for a CMUT array (74) is provided. The acoustic lens comprising: a first layer (47) comprising a thermoset elastomer having a polymeric material selected from hydrocarbons, wherein the first layer has an inner surface (72) arranged to face the array and an outer convex shaped surface (40) arranged to oppose the inner surface; and a second layer (42) coupled to the outer surface of the first layer and comprising thermoplastic polymer polymethylpentene and an elastomer selected from the polyolefin family (POE) blended therein, wherein the outer layer located at the outer surface of the acoustic window layer, wherein the first layer has a first acoustic wave velocity (v1) and the second layer has a second acoustic wave velocity (v2), said second velocity is larger than the first acoustic wave velocity.

Abstract: The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.