Patents by Inventor Maria Chiara Bonini

Maria Chiara Bonini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TCR AND PEPTIDES
    Publication number: 20240132569
    Abstract: A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Application
    Filed: January 20, 2023
    Publication date: April 25, 2024
    Inventors: Maria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
  • TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES
    Publication number: 20230346844
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Application
    Filed: September 12, 2022
    Publication date: November 2, 2023
    Inventors: Maria Chiara Bonini, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang
  • METHOD TO PRODUCE T CELLS AND USES THEREOF
    Publication number: 20230167407
    Abstract: The present invention refers to a method to produce a T cell with advantageous properties. The invention also refers to a T cell or an engineered T cell produced by the method and its use in therapy.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 1, 2023
    Applicant: OSPEDALE SAN RAFFAELE S.R.L.
    Inventors: Barbara CAMISA, Monica CASUCCI, Silvia ARCANGELI, Claudia MEZZANOTTE, Laura FALCONE, Maria Chiara BONINI
  • TCR and peptides
    Patent number: 11597755
    Abstract: TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: March 7, 2023
    Assignees: Ospedale San Raffaele S.r.l., Fondazione Centro San Raffaele
    Inventors: Maria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
  • Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
    Patent number: 11439666
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: September 13, 2022
    Assignees: Sangamo Therapeutics, Inc., Ospedale San Raffaele srl
    Inventors: Maria Chiara Bonini, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang
  • Use of common gamma chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes
    Patent number: 11395835
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: July 26, 2022
    Assignee: OSPEDALE SAN RAFFAELE S.R.L.
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • TCR AND PEPTIDES
    Publication number: 20220119477
    Abstract: A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Application
    Filed: October 31, 2019
    Publication date: April 21, 2022
    Inventors: Maria Chiara Bonini, Eliana Eliana, Zulma Irene Magnani, Fabio Ciceri, Erica Carnevale
  • Chimeric antigen receptors
    Patent number: 11299529
    Abstract: A chimeric antigen receptor (CAR) comprising an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor (LNGFR) or a derivative thereof.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 12, 2022
    Assignee: AGC Biologics S.p.A.
    Inventors: Attilio Bondanza, Monica Casucci, Maria Chiara Bonini
  • Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
    Patent number: 10918668
    Abstract: Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: February 16, 2021
    Assignees: Sangamo Therapeutics, Inc., Ospedale San Raffaele SRL
    Inventors: Philip D. Gregory, Michael C. Holmes, David Paschon, Lei Zhang, Maria Chiara Bonini, Pietro Genovese, Zulma Magnani, Sara Mastaglio, Luigi Naldini
  • TCR AND PEPTIDES
    Publication number: 20200123220
    Abstract: TCR AND PEPTIDES A T-cell receptor (TCR), which binds to a Wilms tumour 1 protein (WT1) peptide when presented by a major histocompatibility complex (MHC).
    Type: Application
    Filed: April 24, 2018
    Publication date: April 23, 2020
    Inventors: Maria Chiara Bonini, Eliana Ruggiero, Zulma Irene Magnani, Luca Aldo Edoardo Vago, Attilio Bondanza, Fabio Ciceri
  • TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES
    Publication number: 20190046579
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Application
    Filed: October 29, 2018
    Publication date: February 14, 2019
    Inventors: Maria Chiara Bonini, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang
  • Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
    Patent number: 10155011
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: December 18, 2018
    Assignees: Sangamo Therapeutics, Inc., Ospedale San Raffaele srl
    Inventors: Maria Chiara Bonini, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang
  • USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES
    Publication number: 20180333434
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 22, 2018
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES
    Publication number: 20180214485
    Abstract: Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 2, 2018
    Inventors: Philip D. Gregory, Michael C. Holmes, David Paschon, Lei Zhang, Maria Chiara Bonini, Pietro Genovese, Zulma Magnani, Sara Mastaglio, Luigi Naldini
  • Use of common ? chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes
    Patent number: 9974808
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: May 22, 2018
    Assignee: OSPEDALE SAN RAFFAELE S.R.L.
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • Targeted disruption of T cell receptor genes using talens
    Patent number: 9937207
    Abstract: Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 10, 2018
    Assignees: Sangamo Therapeutics, Inc., Ospedale San Raffaele SRL
    Inventors: Philip D. Gregory, Michael C. Holmes, David Paschon, Lei Zhang, Maria Chiara Bonini, Pietro Genovese, Zulma Magnani, Sara Mastaglio, Luigi Naldini
  • USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES
    Publication number: 20150306142
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Application
    Filed: March 17, 2015
    Publication date: October 29, 2015
    Inventors: Maria Chiara BONINI, Attilio BONDANZA
  • TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES
    Publication number: 20150164954
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Application
    Filed: January 7, 2015
    Publication date: June 18, 2015
    Inventors: Maria Chiara Bonini, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang
  • Use of common ? chain cytokines for the visualization, isolation and genetic modification of memory T lymphocytes
    Patent number: 8999715
    Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: April 7, 2015
    Assignee: Ospedale San Raffaele S.R.L.
    Inventors: Maria Chiara Bonini, Attilio Bondanza
  • Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
    Patent number: 8956828
    Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: February 17, 2015
    Assignees: Sangamo BioSciences, Inc., Ospedale San Raffaele S.R.L.
    Inventors: Maria Chiara Bonini, Pietro Genovese, Philip D. Gregory, Michael C. Holmes, Luigi Naldini, David Paschon, Elena Provasi, Lei Zhang