Patents by Inventor Maria Cristina BARONI

Maria Cristina BARONI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10421782
    Abstract: A series of cationic cyclic peptides, useful for the treatment of infectious diseases in both human and veterinary clinical/surgical environment are described herein. The peptides of the invention have a length of 15 to 21 amino acids, and show a sequence A-B-C-D-C?-B?-A?, wherein units A and A? correspond to —NH2 terminal and —COOH terminal regions; units B and B? correspond to cyclizable amino acids containing sulfur; units C and C are sequences of 5 amino acids selected among hydrophobic amino acids, basic amino acids and amino acids forming hydrogen bonds; unit D is a dipeptide consisting of glycine and one basic amino acid. Said peptides show significant antibacterial activity, associated with high stability and resistance to the action of bacterial endopeptidases, and weak or null toxicity against eukaryotic cells.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: September 24, 2019
    Assignee: ICF S.r.l.
    Inventors: Maria Cristina Baroni, Clotilde Silvia Cabassi, Antonello Romani
  • Publication number: 20160083427
    Abstract: A series of cationic cyclic peptides, useful for the treatment of infectious diseases in both human and veterinary clinical/surgical environment are described herein. The peptides of the invention have a length of 15 to 21 amino acids, and show a sequence A-B-C-D-C?-B?-A?, wherein units A and A? correspond to —NH2 terminal and —COOH terminal regions; units B and B? correspond to cyclizable amino acids containing sulfur; units C and C are sequences of 5 amino acids selected among hydrophobic amino acids, basic amino acids and amino acids forming hydrogen bonds; unit D is a dipeptide consisting of glycine and one basic amino acid. Said peptides show significant antibacterial activity, associated with high stability and resistance to the action of bacterial endopeptidases, and weak or null toxicity against eukaryotic cells.
    Type: Application
    Filed: December 30, 2013
    Publication date: March 24, 2016
    Inventors: Maria Cristina BARONI, Clotilde Silvia CABASSI, Antonello ROMANI